Abstract
Osteoporosis is a systemic bone disease characterized by a slow but progressive decrease in bone density that results in micro-architecture deterioration, which predisposes to fractures. Fractures are indeed a major concern for the health of individuals, with common fragility fracture sites being found in the hip, spine, and wrist. In 2010 in Europe, there were 22 million women and 5.5 million men with osteoporosis, accounting for 2% of the overall burden of noncommunicable diseases [1]. The mortality associated with major osteoporotic fractures is substantial, with 20% mortality from hip fractures within the first year [2, 3].
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References
Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 8:136
Bliuc D, Alarkawi D, Nguyen TV, Eisman JA, Center JR (2015) Risk of subsequent fractures and mortality in elderly women and men with fragility fractures with and without osteoporotic bone density: the Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res 30:637–646
Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761–1767
Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 22(3):465–475
Watts NB, Adler RA, Bilezikian JP, Drake MT, Eastell R, Orwoll ES (2012) Finkelstein JS; Endocrine Society. Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 97(6):1802–1822
Alswat K, Adler SM (2012) Gender differences in osteoporosis screening: retrospective analysis. Arch Osteoporos 7:311–313
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285(6):785–795. Review
Haentjens P, Magaziner J, Colón-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152(6):380–390
Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby AK (2003) The components of excess mortality after hip fracture. Bone 32(5):468–473
Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353(9156):878–882
Feldstein A, Elmer PJ, Orwoll E, Herson M, Hillier T (2003) Bone mineral density measurement and treatment for osteoporosis in older individuals with fractures: a gap in evidence-based practice guideline implementation. Arch Intern Med 163(18):2165–2172
Feldstein AC, Nichols G, Orwoll E, Elmer PJ, Smith DH, Herson M, Aickin M (2005) The near absence of osteoporosis treatment in older men with fractures. Osteoporos Int 16(8):953–962
Kiebzak GM, Beinart GA, Perser K, Ambrose CG, Siff SJ, Heggeness MH (2002) Undertreatment of osteoporosis in men with hip fracture. Arch Intern Med 162(19):2217–2222
National Osteoporosis Foundation (2014) Clinician’s guide to prevention and treatment of osteoporosis. National Osteoporosis Foundation, Washington, DC. Available from http://nof.org/hcp/clinicians-guide
Lewiecki EM, Gordon CM, Baim S et al (2008) International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions. Bone 43(6):1115–1121
Papaioannou A, Morin S, Cheung AM et al (2010) Scientific Advisory Council of Osteoporosis Canada. 2010 Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 182(17):1864–1873
Compston J, Bowring C, Cooper A et al (2013) National Osteoporosis Guideline Group. Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013. Maturitas 75(4):392–396
Lim SY, Lim JH, Nguyen D, Okamura R, Amiri HM, Calmes M, Nugent K (2013) Screening for osteoporosis in men aged 70 years and older in a primary care setting in the United States. Am J Mens Health 7(4):350–354
Harper CM, Fitzpatrick SK, Zurakowski D, Rozental TD (2014) Distal radial fractures in older men. A missed opportunity? J Bone Joint Surg Am 96(21):1820–1827
Lewiecki EM (2013) Imaging technologies for assessment of skeletal health in men. Curr Osteoporos Rep 11:1–10
Binkley N, Adler R, Bilezikian JP (2014) Osteoporosis diagnosis in men: the T-score controversy revisited. Curr Osteoporos Rep 12:403–409
Kanis JA, Bianchi G, Bilezikian JP, Kaufman JM, Khosla S, Orwoll E, Seeman E (2011) Towards a diagnostic and therapeutic consensus in male osteoporosis. Osteoporos Int 22:2789–2798
Kanis JA, McCloskey EV, Johansson H, Oden A, Melton LJ 3rd, Khaltaev N (2008) A reference standard for the description of osteoporosis. Bone 42:467–475
Looker AC, Orwoll ES, Johnston CC Jr, Lindsay RL, Wahner HW, Dunn WL et al (1997) Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res 12:1761–1768
Khosla S, Amin S, Orwoll E (2008) Osteoporosis in men. Endocr Rev 29:441–464
Pasco JA, Lane SE, Brennan SL, Timney EN, Bucki-Smith G, Dobbins AG, Nicholson GC, Kotowicz MA (2014) Fracture risk among older men: osteopenia and osteoporosis defined using cut-points derived from female versus male reference data. Osteoporos Int 25:857–862
Harvey NC, Johansson H, Oden A, Karlsson MK, Rosengren BE, Ljunggren O, Cooper C, McCloskey E, Kanis JA, Ohlsson C, Mellstrom D (2016) FRAX predicts incident falls in elderly men: findings from MrOs Sweden. Osteoporos Int 27:267–274
Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 25:2359–2381
Vescini F, Attanasio R, Balestrieri A, Bandeira F, Bonadonna S, Camozzi V, Cassibba S, Cesareo R, Chiodini I, Francucci CM, Gianotti L, Grimaldi F, Guglielmi R, Madeo B, Marcocci C, Palermo A, Scillitani A, Vignali E, Rochira V, Zini M (2016) Italian association of clinical endocrinologists (AME) position statement: drug therapy of osteoporosis. J Endocrinol Invest 39:807–834
Boonen S, Reginster JY, Kaufman JM, Lippuner K, Zanchetta J, Langdahl B, Rizzoli R, Lipschitz S, Dimai HP, Witvrouw R, Eriksen E, Brixen K, Russo L, Claessens F, Papanastasiou P, Antunez O, Su G, Bucci-Rechtweg C, Hruska J, Incera E, Vanderschueren D, Orwoll E (2012) Fracture risk and zoledronic acid therapy in men with osteoporosis. N Engl J Med 367:1714–1723
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Foresta, C. (2020). Introduction: Gender Differences in Osteoporosis: From Research to Treatment. In: Ferlin, A., Migliaccio, S. (eds) Male Osteoporosis. Trends in Andrology and Sexual Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-96376-1_1
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DOI: https://doi.org/10.1007/978-3-319-96376-1_1
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