Biotherapy Treatment: Mesothelin-Targeted Therapies

Abstract

The use of targeted therapies can provide mesothelioma patients with innovative treatment options. Mesothelin is a protein expressed in mesothelioma as well as other cancers including pancreas, ovarian, and lung cancer. A number of agents have been evaluated as potential treatments for malignant mesothelioma, including immunotoxins, monoclonal antibodies, antibody drug conjugates, vaccines, and chimeric antigen receptor T cells (CAR-T cells). Each targeted therapy has a unique toxicity profile, which requires a team of specialists to appropriately treat and resolve those toxicities. This chapter focuses on the role of mesothelin as a biological target of treatment.