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Pharmacological Options for NASH

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Non-Alcoholic Fatty Liver Disease

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Abstract

Nonalcoholic steatohepatitis (NASH) is becoming the leading cause of chronic liver disease and a major health issue owing to its close association with the worldwide epidemics of obesity and diabetes [1]. A significant proportion of patients can experience disease progression with the occurrence of cirrhosis, hepatocellular carcinoma and end-stage liver disease [2]. This results in an increase in the overall and liver-related mortality [3, 4]. Patients at risk of disease progression need to be identified as not all individuals with metabolic risk factors will experience disease progression [5]. Prognostic markers have mostly been derived from histological studies and found that the degree of inflammation is the strongest and independent predictor for fibrosis progression [6]. Thus, therapies that could reduce liver inflammation would be the most meaningful option to control this disease.

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  1. Sorbonne Université, ICAN—Institute for Cardiometabolism and Nutrition, Hôpital Pitié Salpêtrière, Paris, France

    Christiane Stern & Vlad Ratziu

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    Elisabetta Bugianesi

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Stern, C., Ratziu, V. (2020). Pharmacological Options for NASH. In: Bugianesi, E. (eds) Non-Alcoholic Fatty Liver Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-95828-6_17

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