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Neurorehabilitation in Neuro-Oncology pp 37–51Cite as

Clinical Concepts of Brain Tumors

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Abstract

Neurological symptoms and signs of brain tumors are not specifically tied to individual specific tumor types, but rather to location within the central nervous system (CNS). Tumor can damage neural tissue by infiltration or displace by compression, leading to focal symptoms. Direct invasion from a tumor typically occurs in gliomas, whereas meningiomas displace normal brain. The disruption of the blood–brain barrier by the tumor leads to vasogenic edema that is one of the main causes of neurological impairment: edema favors an increase of mass effect and thus a further compression of the surrounding brain [1].

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References

  1. Alentorn A, Hoang-Xuan K, Mikkelsen T. Presenting signs and symptoms in brain tumors. Handb Clin Neurol. 2016;134:19–26.

    Article  PubMed  Google Scholar 

  2. Posner JB, Saper CB, Schiff N, et al. Plum and Posner’s diagnosis of stupor and coma. Oxford: Oxford University Press; 2007.

    Google Scholar 

  3. Reddy GK, Bollam P, Caldito G, Willis B, Guthikonda B, Nanda A. Ventriculoperitoneal shunt complications in hydrocephalus patients with intracranial tumors: an analysis of relevant risk factors. J Neurooncol. 2011;103(2):333–42.

    Article  PubMed  Google Scholar 

  4. Malamud N. Psychiatric disorder with intracranial tumors of limbic system. Arch Neurol. 1967;17(2):113–23.

    Article  CAS  PubMed  Google Scholar 

  5. Weitzner MA. Psychosocial and neuropsychiatric aspects of patients with primary brain tumors. Cancer Invest. 1999;17(4):285–91.

    Article  CAS  PubMed  Google Scholar 

  6. Forsyth PA, Posner JB. Headaches in patients with brain tumors: a study of 111 patients. Neurology. 1993;43(9):1678–83.

    Article  CAS  PubMed  Google Scholar 

  7. Vázquez-Barquero A, Ibáñez FJ, Herrera S, Izquierdo JM, Berciano J, Pascual J. Isolated headache as the presenting clinical manifestation of intracranial tumors: a prospective study. Cephalalgia. 1994;14(4):270–2.

    Article  PubMed  Google Scholar 

  8. Schaefer PW, Miller JC, Singhal AB, Thrall JH, Lee SI. Headache: when is neurologic imaging indicated? J Am Coll Radiol. 2007;4(8):566–9.

    Article  PubMed  Google Scholar 

  9. Chen C, Yen DJ, Yiu CH, Shih YH, Yu HY, Su MS. Ictal vomiting in partial seizures of temporal lobe origin. Eur Neurol. 1999;42(4):235–9.

    Article  CAS  PubMed  Google Scholar 

  10. Biller J, Brazis PW, Masdeu JC. Localization in clinical neurology. Philadelphia: Wolters Kluwer Health; 2011.

    Google Scholar 

  11. Raelson C, Chiang G. Chiasmatic-hypothalamic masses in adults: a case series and review of the literature. J Neuroimaging. 2015;25(3):361–4.

    Article  PubMed  Google Scholar 

  12. Sathananthan M, Sathananthan A, Scheithauer BW, Giannini C, Meyer FB, Atkinson JL, Erickson D. Sellar meningiomas: an endocrinologic perspective. Pituitary. 2013;16(2):182–8.

    Article  PubMed  Google Scholar 

  13. Soffietti R, Ducati A, Rudà R. Brain metastases. Handb Clin Neurol. 2012;105:747–55.

    Article  CAS  PubMed  Google Scholar 

  14. Politsky JM. Brain tumor-related epilepsy: a current review of the etiologic basis and diagnostic and treatment approaches. Curr Neurol Neurosci Rep. 2017;17(9):70.

    Article  PubMed  CAS  Google Scholar 

  15. Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsy-a review. Epilepsy Res. 2009;85(1):31–45.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Rudà R, Bello L, Duffau H, Soffietti R. Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments. Neuro Oncol. 2012;14(Suppl 4):iv55–64.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  17. Shady JA, Black PM, Kupsky WJ, Tarbell NJ, Scott RM, Leong T, Holmes G. Seizures in children with supratentorial astroglial neoplasms. Pediatr Neurosurg. 1994;21(1):23–30.

    Article  CAS  PubMed  Google Scholar 

  18. Shamji MF, Fric-Shamji EC, Benoit BG. Brain tumors and epilepsy: pathophysiology of peritumoral changes. Neurosurg Rev. 2009;32(3):275–84. discussion 284–6.

    Article  PubMed  Google Scholar 

  19. Rudà R, Soffietti R. What is new in the management of epilepsy in gliomas? Curr Treat Options Neurol. 2015;17(6):351.

    Article  PubMed  Google Scholar 

  20. Wolf H, Roos D, Blumcke I, Pietsch T, Wiestler O. Perilesional neurochemical changes in focal epilepsies. Acta Neuropathol. 1996;91:376–84.

    Article  CAS  PubMed  Google Scholar 

  21. Kohling R, Senner V, Paulus W, Speckmann E. Epileptiform activity preferentially arises outside tumor invasion zone in glioma xeno-transplants. Neurobiol Dis. 2006;22:64–75.

    Article  PubMed  CAS  Google Scholar 

  22. Yuen T, Morokoff A, Bjorksten A, D’Abaco G, Paradiso L, Finch S, et al. Glutamate is associated with a higher risk of seizures in patients with gliomas. Neurology. 2012;79:883–9.

    Article  CAS  PubMed  Google Scholar 

  23. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kälviäinen R, ILAE Subcommission on AED Guidelines, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013;54(3):551–63.

    Article  CAS  PubMed  Google Scholar 

  24. Kerrigan S, Grant R. Antiepileptic drugs for treating seizures in adults with brain tumours. Cochrane Database Syst Rev. 2011;8:CD008586.

    Google Scholar 

  25. Vecht CJ, Kerkhof M, Duran-Pena A. Seizure prognosis in brain tumors: new insights and evidence-based management. Oncologist. 2014;19:751–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Kerkhof M, Dielemans JC, van Breemen MS, et al. Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme. Neuro-Oncology. 2013;15:961–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Rudà R, Pellerino A, Franchino F, Bertolotti C, Bruno F, Mo F, Migliore E, Ciccone G, Soffietti R. Lacosamide in patients with gliomas and uncontrolled seizures: results from an observational study. J Neuro-Oncol. 2018;136(1):105–14.

    Article  CAS  Google Scholar 

  28. Lacy J, Saadati H, Yu JB. Complications of brain tumors and their treatment. Hematol Oncol Clin North Am. 2012;26(4):779–96.

    Article  PubMed  Google Scholar 

  29. Bourdillon P, Apra C, Guenot M, Duffau H. Similarity and differences in neuroplasticity mechanisms between brain gliomas and nonlesional epilepsy. Epilepsia. 2017;58(12):2038–47.

    Article  PubMed  Google Scholar 

  30. Duffau H. Brain mapping in tumors: intraoperative or extraoperative. Epilepsia. 2013;54(Suppl 9):79–83.

    Article  PubMed  Google Scholar 

  31. Duffau H. The challenge to remove diffuse low grade gliomas while preserving brain functions. Acta Neurochir. 2012;154:569–74.

    Article  PubMed  Google Scholar 

  32. Rudà R, Trevisan E, Soffietti R. Epilepsy and brain tumors. Curr Opin Oncol. 2010;22(6):611–20.

    Article  PubMed  Google Scholar 

  33. Roelcke U, Wyss MT, Nowosielski M, Rudà R, Roth P, Hofer S, Galldiks N, Crippa F, Weller M, Soffietti R. Amino acid positron emission tomography to monitor chemotherapy response and predict seizure control and progression-free survival in WHO grade II gliomas. Neuro Oncol. 2016;18(5):744–51.

    Article  CAS  PubMed  Google Scholar 

  34. Rudà R, Magliola U, Bertero L, Trevisan E, Bosa C, Mantovani C, Ricardi U, Castiglione A, Monagheddu C, Soffietti R. Seizure control following radiotherapy in patients with diffuse gliomas: a retrospective study. Neuro Oncol. 2013;15(12):1739–49.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Avila EK, Chamberlain M, Schiff D, Reijneveld JC, Armstrong TS, Ruda R, Wen PY, Weller M, Koekkoek JA, Mittal S, Arakawa Y, Choucair A, Gonzalez-Martinez J, MacDonald DR, Nishikawa R, Shah A, Vecht CJ, Warren P, van den Bent MJ, DeAngelis LM. Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials. Neuro Oncol. 2017;19(1):12–21.

    Article  PubMed  Google Scholar 

  36. Mohile NA. Medical complications of brain tumors. Continuum (Minneap Minn). 2017;23(6, Neuro-oncology):1635–52.

    Google Scholar 

  37. Machein MR, Kullmer J, Fiebich BL, et al. Vascular endothelial growth factor expression, vascular volume, and, capillary permeability in human brain tumors. Neurosurgery. 1999;44(4):732Y740. discussion 740Y741.

    Article  Google Scholar 

  38. Gerstner ER, Duda DG, di Tomaso E, et al. VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer. Nat Rev Clin Oncol. 2009;6(4):229Y236.

    Article  CAS  Google Scholar 

  39. Schiff D. Pneumocystis pneumonia in brain tumor patients: risk factors and clinical features. J Neurooncol. 1996;27(3):235Y240.

    Article  Google Scholar 

  40. Leuthardt EC, Wippold FJ 2nd, Oswood MC, Rich KM. Diffusion-weighted MR imaging in the preoperative assessment of brain abscesses. Surg Neurol. 2002;58(6):395–402.

    Article  PubMed  Google Scholar 

  41. Streiff MB, Ye X, Kickler TS, et al. A prospective multicenter study of venous thromboembolism in patients with newly-diagnosed high-grade glioma: hazard rate and risk factors. J Neurooncol. 2015;124(2):299–305.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Alshehri N, Cote DJ, Hulou MM, et al. Venous thromboembolism prophylaxis in brain tumor patients undergoing craniotomy: a meta-analysis. J Neurooncol. 2016;130(3):561–70.

    Article  CAS  PubMed  Google Scholar 

  43. Gerber DE, Grossman SA, Streiff MB. Management of venous thromboembolism in patients with primary and metastatic brain tumors. J Clin Oncol. 2006;24(8):1310–8.

    Article  CAS  PubMed  Google Scholar 

  44. Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349(2):146–53.

    Article  CAS  PubMed  Google Scholar 

  45. Levin JM, Schiff D, Loeffler JS, et al. Complications of therapy for venous thromboembolic disease in patients with brain tumors. Neurology. 1993;43(6):1111–4.

    Article  CAS  PubMed  Google Scholar 

  46. Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):699–708.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Kreisl TN, Toothaker T, Karimi S, DeAngelis LM. Ischemic stroke in patients with primary brain tumors. Neurology. 2008;70(24):2314–20.

    Article  PubMed  Google Scholar 

  48. Roongpiboonsopit D, Kuijf HJ, Charidimou A, et al. Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients. Neurology. 2017;88(8):789–96.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Roddy E, Sear K, Felton E, et al. Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. Neuro Oncol. 2016;18(11):1548–58.

    PubMed  PubMed Central  Google Scholar 

  50. McGirt MJ, Chaichana KL, Gathinji M, et al. Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. Neurosurgery. 2008;63(2):286–91.

    Article  PubMed  Google Scholar 

  51. Sathyapalan T, Dixit S. Radiotherapy-induced hypopituitarism: a review. Expert Rev Anticancer Ther. 2012;12(5):669–83.

    Article  CAS  PubMed  Google Scholar 

  52. Pietilä S, Mäkipernaa A, Koivisto AM, Lenko HL. Growth impairment and gonadal axis abnormalities are common in survivors of paediatric brain tumours. Acta Paediatr. 2017;106(10):1684–93.

    Article  PubMed  CAS  Google Scholar 

  53. Rooney AG, Carson A, Grant R. Depression in cerebral glioma patients: a systematic review of observational studies. J Natl Cancer Inst. 2011;103(1):61–76.

    Article  PubMed  Google Scholar 

  54. Douw L, Klein M, Fagel SS, et al. Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol. 2009;8(9):810–8.

    Article  PubMed  Google Scholar 

  55. Kaiser J, Bledowski C, Dietrich J. Neural correlates of chemotherapy-related cognitive impairment. Cortex. 2014;54:33–50.

    Article  PubMed  Google Scholar 

  56. Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV. Management of glioblastoma in elderly patients. J Neurol Sci. 2017;380:250–5.

    Article  CAS  PubMed  Google Scholar 

  57. de Moraes FY, Laperriere N. Glioblastoma in the elderly: initial management. Chin Clin Oncol. 2017;6(4):39.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy

    Carlotta Chiavazza, Federica Franchino & Roberta Rudà

Authors
  1. Carlotta Chiavazza
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  2. Federica Franchino
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  3. Roberta Rudà
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Editors and Affiliations

  1. Department of Rehabilitation, Neurorehabilitation Unit, Habilita S.p.A., Zingonia/Ciserano, Bergamo, Italy

    Michelangelo Bartolo

  2. University and City of Health and Science, Department Neuro-Oncology, Turin, Torino, Italy

    Riccardo Soffietti

  3. Department of Medical Psychology, VU University Medical Center Department of Medical Psychology, Amsterdam, The Netherlands

    Martin Klein

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Chiavazza, C., Franchino, F., Rudà, R. (2019). Clinical Concepts of Brain Tumors. In: Bartolo, M., Soffietti, R., Klein, M. (eds) Neurorehabilitation in Neuro-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-95684-8_4

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  • DOI: https://doi.org/10.1007/978-3-319-95684-8_4

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