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Biomechanics in Oncology pp 253–287Cite as

Biomaterials in Mechano-oncology: Means to Tune Materials to Study Cancer

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1092)

Abstract

ECM stiffness is emerging as a prognostic marker of tumor aggression or potential for relapse. However, conflicting reports muddle the question of whether increasing or decreasing stiffness is associated with aggressive disease. This chapter discusses this controversy in more detail, but the fact that tumor stiffening plays a key role in cancer progression and in regulating cancer cell behaviors is clear. The impact of having in vitro biomaterial systems that could capture this stiffening during tumor evolution is very high. These cell culture platforms could help reveal the mechanistic underpinnings of this evolution, find new therapeutic targets to inhibit the cross talk between tumor development and ECM stiffening, and serve as better, more physiologically relevant platforms for drug screening.

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA, USA

    Shelly R. Peyton, Maria F. Gencoglu, Sualyneth Galarza & Alyssa D. Schwartz

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  1. Shelly R. Peyton
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  2. Maria F. Gencoglu
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  3. Sualyneth Galarza
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  4. Alyssa D. Schwartz
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Correspondence to Shelly R. Peyton .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA

    Cheng Dong

  2. Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Nastaran Zahir

  3. Department of Chemical and Biomolecular Engineering Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA

    Konstantinos Konstantopoulos

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Peyton, S.R., Gencoglu, M.F., Galarza, S., Schwartz, A.D. (2018). Biomaterials in Mechano-oncology: Means to Tune Materials to Study Cancer. In: Dong, C., Zahir, N., Konstantopoulos, K. (eds) Biomechanics in Oncology. Advances in Experimental Medicine and Biology, vol 1092. Springer, Cham. https://doi.org/10.1007/978-3-319-95294-9_13

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