Notch Signaling Pathway in Carcinogenesis

  • Andrei Zlobin
  • Jeffrey C. Bloodworth
  • Andrew T. Baker
  • Clodia OsipoEmail author


The Notch signaling pathway is a highly conserved pathway in most multicellular organisms. It is of critical importance for cell proliferation, differentiation, and homeostasis. Aberrant Notch signaling can give rise to a number of pathologies including cancer. The Notch signaling pathway consists of a well-orchestrated series of biochemical events that provide multiple avenues for rational drug design. Design of targeted therapies focusing on Notch signaling is rapidly advancing. This review will aim to discuss the established and recent approaches to targeting the Notch pathway.


Notch Cancer Gamma secretase Development Stem cell 


Conflict of Interest

The authors have no conflict of interest.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Andrei Zlobin
    • 1
  • Jeffrey C. Bloodworth
    • 2
  • Andrew T. Baker
    • 3
  • Clodia Osipo
    • 4
    Email author
  1. 1.Oncology Research InstituteLoyola University Medical CenterMaywoodUSA
  2. 2.Cardinal Bernardin Cancer CenterLoyola University ChicagoMaywoodUSA
  3. 3.Department of Integrative Cell BiologyLoyola University ChicagoMaywoodUSA
  4. 4.Department of Microbiology and ImmunologyStritch School of Medicine, Cardinal Bermardin Cancer Center of Loyola University ChicagoMaywoodUSA

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