A Biochip Based Medical Device for Point-of-Care ABO Compatibility: Towards a Smart Transfusion Line

  • Karine Charrière
  • Alain Rouleau
  • Olivier Gaiffe
  • Pascal Morel
  • Véronique Bourcier
  • Christian Pieralli
  • Wilfrid Boireau
  • Lionel Pazart
  • Bruno WacogneEmail author
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 881)


ABO mismatch between donor and patient’s blood is still the cause of accidents which are sometimes lethal. The main causes of mis-assignment are human errors and wrong identification of patients or blood product. Only a final compatibility test at the patient’s bedside can avoid these errors. In some countries, this test is performed using manual procedures. This does not prevent from human manipulation and interpretation errors. In this paper, we present a prototype able to automatically perform a final ABO compatibility test. It relies on the use of disposable antibodies grafted biochips inserted into a mobile reader/actuator. Red blood cells are selectively captured on biochips grafted with antibodies complementary of antigens present on the cells surface. Detection of captured cells is based on optical absorption techniques. So far, our device achieved blood compatibility test with 99.3% sensitivity and 97.9% specificity.


Biosensor Surface Plasmon Resonance Human red blood cells Automated ABO compatibility test Optical detection Opto-fluidic prototype 



This work was partly supported by the EFS (grant DECO-13-0128), the INSERM-CNRS (patent file CNRS/REF:02682-V), OSEO and the University of Franche-Comté (grant A1105005I). This work is developed in the frame of the French RENATECH network and the Biom’@x transversal axis at FEMTO-ST.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Karine Charrière
    • 1
  • Alain Rouleau
    • 2
  • Olivier Gaiffe
    • 2
  • Pascal Morel
    • 3
  • Véronique Bourcier
    • 4
  • Christian Pieralli
    • 2
  • Wilfrid Boireau
    • 2
  • Lionel Pazart
    • 1
  • Bruno Wacogne
    • 1
    • 2
    Email author
  1. 1.INSERM CIC 1431, Besançon University HospitalBesançon cedexFrance
  2. 2.FEMTO-ST Institute, Univ. Bourgogne Franche-Comté, CNRSBesançon cedexFrance
  3. 3.Etablissement Français du Sang Bourgogne/Franche-ComtéBesançon cedexFrance
  4. 4.Hemovigilance Service, Besançon University HospitalBesançon cedexFrance

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