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Do Vaccines Cause Asthma?

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Abstract

Natural infection with influenza can contribute to asthma exacerbation. Thus, influenza vaccine prevents asthma exacerbation by protecting against natural infection. Influenza vaccines do not cause asthma or asthma exacerbation. Other vaccines currently routinely recommended to the general population in the U.S. have not been shown to cause asthma or asthma exacerbation.

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Notes

  1. 1.

    These conclusions do not necessarily consider vaccines recommended only for special populations in the United States such as Yellow Fever vaccine (international travelers) or Smallpox vaccine (military personnel).

References

  1. Institute of Medicine, in Adverse Effects of Vaccines: Evidence and Causality, K. Stratton, et al., Editors. 2012, National Academies Press (US): Washington (DC).

    Google Scholar 

  2. The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med, 2001. 345(21): p. 1529–36.

    Google Scholar 

  3. Bueving, H.J., et al., Does influenza vaccination exacerbate asthma in children? Vaccine, 2004. 23(1): p. 91–6.

    Article  Google Scholar 

  4. France, E.K., et al., Safety of the trivalent inactivated influenza vaccine among children: a population-based study. Arch Pediatr Adolesc Med, 2004. 158(11): p. 1031–6.

    Article  Google Scholar 

  5. Hambidge, S.J., et al., Safety of trivalent inactivated influenza vaccine in children 6 to 23 months old. JAMA, 2006. 296(16): p. 1990–7.

    Article  CAS  Google Scholar 

  6. Kmiecik, T., et al., Influenza vaccination in adults with asthma: safety of an inactivated trivalent influenza vaccine. J Asthma, 2007. 44(10): p. 817–22.

    Article  CAS  Google Scholar 

  7. Nicholson, K.G., et al., Randomised placebo-controlled crossover trial on effect of inactivated influenza vaccine on pulmonary function in asthma. Lancet, 1998. 351(9099): p. 326–31.

    Article  CAS  Google Scholar 

  8. Pedroza, A., et al., The safety and immunogenicity of influenza vaccine in children with asthma in Mexico. Int J Infect Dis, 2009. 13(4): p. 469–75.

    Article  Google Scholar 

  9. Stenius-Aarniala, B., et al., Lack of clinical exacerbations in adults with chronic asthma after immunization with killed influenza virus. Chest, 1986. 89(6): p. 786–9.

    Article  CAS  Google Scholar 

  10. Tata, L.J., et al., Does influenza vaccination increase consultations, corticosteroid prescriptions, or exacerbations in subjects with asthma or chronic obstructive pulmonary disease? Thorax, 2003. 58(10): p. 835–9.

    Article  CAS  Google Scholar 

  11. Belshe, R.B., et al., Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med, 2007. 356(7): p. 685–96.

    Article  CAS  Google Scholar 

  12. Ashkenazi, S., et al., Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J, 2006. 25(10): p. 870–9.

    Article  Google Scholar 

  13. Belshe, R.B., et al., Safety, efficacy, and effectiveness of live, attenuated, cold-adapted influenza vaccine in an indicated population aged 5–49 years. Clin Infect Dis, 2004. 39(7): p. 920–7.

    Article  Google Scholar 

  14. Bergen, R., et al., Safety of cold-adapted live attenuated influenza vaccine in a large cohort of children and adolescents. Pediatr Infect Dis J, 2004. 23(2): p. 138–44.

    Article  Google Scholar 

  15. Gaglani, M.J., et al., Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with intermittent wheezing in an open-label field trial. Pediatr Infect Dis J, 2008. 27(5): p. 444–52.

    Article  Google Scholar 

  16. Piedra, P.A., et al., Live attenuated influenza vaccine, trivalent, is safe in healthy children 18 months to 4 years, 5 to 9 years, and 10 to 18 years of age in a community-based, nonrandomized, open-label trial. Pediatrics, 2005. 116(3): p. e397–407.

    Article  Google Scholar 

  17. Fleming, D.M., et al., Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J, 2006. 25(10): p. 860–9.

    Article  Google Scholar 

  18. Halsey, N.A., et al., The safety of influenza vaccines in children: An Institute for Vaccine Safety white paper. Vaccine, 2015. 33: p. F1–F67.

    Article  Google Scholar 

  19. Turner, P.J., et al., Safety of live attenuated influenza vaccine in young people with egg allergy: multicentre prospective cohort study. Bmj, 2015. 351: p. h6291.

    Google Scholar 

  20. Turner, P.J., et al., Safety of live attenuated influenza vaccine in atopic children with egg allergy. J Allergy Clin Immunol, 2015. 136(2): p. 376–81.

    Google Scholar 

  21. Baxter, R., et al., Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2–49years. Vaccine, 2017. 35(9): p. 1254–8.

    Article  CAS  Google Scholar 

  22. Timmermann, C.A., et al., Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination. Pediatr Allergy Immunol, 2015. 26(8): p. 742–9.

    Article  Google Scholar 

  23. Jackson, D.J. and S.L. Johnston, The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol, 2010. 125(6): p. 1178–87; quiz 1188–9.

    Article  CAS  Google Scholar 

  24. de Jongste, J.C., et al., Bronchial responsiveness and leucocyte reactivity after influenza vaccine in asthmatic patients. Eur J Respir Dis, 1984. 65(3): p. 196–200.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Epidemiologist, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Matthew Z. Dudley PhD, MSPH

  2. Professor, Departments of International Health and Health, Behavior and Society, Director, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Daniel A. Salmon PhD, MPH

  3. Professor Emeritus, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Professor Emeritus, Department of Pediatrics, Johns Hopkins School of Medicine, Director Emeritus, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Neal A. Halsey MD

  4. Professor of Medicine, Pediatrics, Global Health, and Epidemiology, Emory University, Associate Director, Emory Vaccine Center, Director, Center of Excellence for Influenza Research and Surveillance (Emory-UGA CEIRS), Former President, National Foundation for Infectious Diseases (NFID), Atlanta, GA, USA

    Walter A. Orenstein MD, DSc (Hon)

  5. Associate Director for Behavioral Research, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Rupali J. Limaye PhD, MPH, MA

  6. Associate Professor, Pediatrics-Infectious Diseases, University of Colorado School of Medicine, Denver, CO, USA

    Sean T. O’Leary MD, MPH

  7. William H. Foege Professor of Global Health, Professor of Epidemiology and Pediatrics, Emory University, Atlanta, GA, USA

    Saad B. Omer MBBS, PhD, MPH

Authors
  1. Matthew Z. Dudley PhD, MSPH
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  2. Daniel A. Salmon PhD, MPH
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  3. Neal A. Halsey MD
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  4. Walter A. Orenstein MD, DSc (Hon)
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  5. Rupali J. Limaye PhD, MPH, MA
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  6. Sean T. O’Leary MD, MPH
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  7. Saad B. Omer MBBS, PhD, MPH
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Dudley, M.Z. et al. (2018). Do Vaccines Cause Asthma?. In: The Clinician’s Vaccine Safety Resource Guide. Springer, Cham. https://doi.org/10.1007/978-3-319-94694-8_24

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  • DOI: https://doi.org/10.1007/978-3-319-94694-8_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94693-1

  • Online ISBN: 978-3-319-94694-8

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