A Computational Model-Based Framework to Plan Clinical Experiments – An Application to Vascular Adaptation Biology

Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10860)

Abstract

Several computational models have been developed in order to improve the outcome of Vein Graft Bypasses in response to arterial occlusions and they all share a common property: their accuracy relies on a winning choice of the coefficients’ value related to biological functions that drive them. Our goal is to optimize the retrieval of these unknown coefficients on the base of experimental data and accordingly, as biological experiments are noisy in terms of statistical analysis and the models are typically stochastic and complex, this work wants first to elucidate which experimental measurements might be sufficient to retrieve the targeted coefficients and second how many specimens would constitute a good dataset to guarantee a sufficient level of accuracy. Since experiments are often costly and time consuming, the planning stage is critical to the success of the operation and, on the base of this consideration, the present work shows how, thanks to an ad hoc use of a computational model of vascular adaptation, it is possible to estimate in advance the entity and the quantity of resources needed in order to efficiently reproduce the experimental reality.

Keywords

Agent based model Experiment planning Virtual dataset 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Stefano Casarin
    • 1
    • 2
    • 3
  • Scott A. Berceli
    • 4
    • 5
  • Marc Garbey
    • 1
    • 2
    • 3
  1. 1.LASIE UMR 7356 CNRS, University of La RochelleLa RochelleFrance
  2. 2.Center for Computational Surgery, Houston Methodist Research InstituteHoustonUSA
  3. 3.Department of SurgeryHouston Methodist HospitalHoustonUSA
  4. 4.Department of SurgeryUniversity of FloridaGainesvilleUSA
  5. 5.Malcom Randall VAMCGainesvilleUSA

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