3D Printing and Adenosine Receptor Activation for Craniomaxillofacial Regeneration
- 610 Downloads
The evolution of maxillofacial reconstruction has led to advancements in patient-specific treatment plans. While the fusion of craniomaxillofacial and microvascular principles has given rise to reconstructive tools capable of approaching normalcy, limitations persist. Although the promise of bone tissue engineering has yet to be realized, promising translational developments have been reported. This chapter summarizes our group’s recent advances in materials science and 3D printing, bioactive molecule osteogenic stimulation, and their integration toward the development of devices capable of maxillofacial bony restoration.
Keywords3D printing Bio-ceramic scaffolds Calcium phosphate biomaterials Adenosine receptors Dipyridamole
We would like to wholeheartedly thank Dr. Joseph G. McCarthy for his endorsement of our work and contributions to this chapter. His insight on advances and setbacks in craniomaxillofacial surgery over the last quarter of a century provides us with the unique opportunity to focus on clinically relevant challenges that have challenged reconstructive surgeons for decades.
The work presented in this chapter was supported by NIH/NIAMS 5R01AR068593-02, 3R01AR068593-02S1, 5R01AR068593-03, & 3R01AR068593-03S1, NIH/NICHD R21HD090664-01, and DoD W81XWH-16-1-0772. Drs. Coelho and Cronstein are co-inventors of the 3D printing technology presented in this chapter.
- 10.Jimbo R, Anchieta R, Baldassarri M, Granato R, Marin C, Teixeira HS, Tovar N, Vandeweghe S, Janal MN, Coelho PG. Histomorphometry and bone mechanical property evolution around different implant systems at early healing stages: an experimental study in dogs. Implant Dent. 2013;22(6):596–603.CrossRefGoogle Scholar
- 12.Ishack S, Mediero A, Wilder T, Ricci JL, Cronstein BN. Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2. J Biomed Mater Res B Appl Biomater. 2017;105(2):366–75.CrossRefGoogle Scholar
- 21.Yao Q, Wei B, Guo Y, Jin C, Du X, Yan C, et al. Design, construction and mechanical testing of digital 3D anatomical data-based PCL–HA bone tissue engineering scaffold. J Mater Sci Mater Med. 2015;26(1):1–9.Google Scholar
- 26.Xinning Y, Jinghua F, Jianyang L, Xianyan Y, Dongshuang H, Zhongru G, et al. [Fabrication of bioactive tissue engineering scaffold for reconstructing calcified cartilage layer based on three-dimension printing technique]. Zhejiang da xue xue bao Yi xue ban= Journal of Zhejiang University Medical. Sciences. 2016;45(2):126–31.Google Scholar
- 41.Kara FM, Doty SB, Boskey A, Goldring S, Zaidi M, Fredholm BB, et al. Adenosine A1 receptors regulate bone resorption in mice: adenosine A1 receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A1 receptor–knockout mice. Arthritis Rheum. 2010;62(2):534–41.CrossRefGoogle Scholar
- 48.Patrono C, Coller B, Dalen JE, Fuster V, Gent M, Harker LA, et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest. 1998;114(5 Suppl):234S–64S.Google Scholar
- 49.Monagle P, Chan AKCKC, Goldenberg NA, Ichord RN, Journeycake JM, Nowak-Göttl U, et al. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e737S–801S.CrossRefGoogle Scholar
- 50.Ishack S, Mediero A, Wilder T, Ricci JL, Cronstein BN. Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2. J Biomed Mater Res B Appl Biomater. 2017;105(2):366–75.CrossRefGoogle Scholar