Crandall CG, González-Alonso J. Cardiovascular function in the heat-stressed human. Acta Physiol. 2010;199(4):407–23.
Tipton CM. Medicine AC of S. ACSM’s advanced exercise physiology. Philadelphia: Lippincott Williams & Wilkins; 2006.
Rowell LB, Murray JA, Brengelmann GL, Kraning KK. Human cardiovascular adjustments to rapid changes in skin temperature during exercise. Circ Res. 1969;24(5):711–24.
Minson CT, Wladkowski SL, Cardell AF, Pawelczyk JA, Kenney WL. Age alters the cardiovascular response to direct passive heating. J Appl Physiol. 1998;84(4):1323–32.
Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol. 1985;366(1):233–49.
Mortensen SP, Dawson EA, Yoshiga CC, Dalsgaard MK, Damsgaard R, Secher NH, et al. Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans. J Physiol. 2005;566(1):273–85.
Mortensen SP, Damsgaard R, Dawson EA, Secher NH, González-Alonso J. Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and VO2 during high-intensity whole-body exercise in humans. J Physiol. 2008;586(10):2621–35.
Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev. 1974;54(1):75–159.
Kenney WL, Stanhewicz AE, Bruning RS, Alexander LM. Blood pressure regulation III: what happens when one system must serve two masters: temperature and pressure regulation? Eur J Appl Physiol. 2014;114(3):467–79.
Pearson J, Low DA, Stöhr E, Kalsi K, Ali L, Barker H, et al. Hemodynamic responses to heat stress in the resting and exercising human leg: insight into the effect of temperature on skeletal muscle blood flow. AJP Regul Integr Comp Physiol. 2011;300(3):R663–73.
White MD. Components and mechanisms of thermal hyperpnea. J Appl Physiol. 2006;101(2):655–63.
Ogoh S, Sato K, Okazaki K, Miyamoto T, Hirasawa A, Morimoto K, et al. Blood flow distribution during heat stress: cerebral and systemic blood flow. J Cereb Blood Flow Metab. 2013;33(12):1915–20.
Rowell LB, Brengelmann GL, Murray JA. Cardiovascular responses to sustained high skin temperature in resting man. J Appl Physiol. 1969;27(5):673–80.
Bonde-Petersen F, Schultz-Pedersen L, Dragsted N. Peripheral and central blood flow in man during cold, thermoneutral, and hot water immersion. Aviat Space Environ Med. 1992;63(5):346–50.
Niimi Y, Matsukawa T, Sugiyama Y, Shamsuzzaman ASM, Ito H, Sobue G, et al. Effect of heat stress on muscle sympathetic nerve activity in humans. J Auton Nerv Syst. 1997;63(1):61–7.
Ganio MS, Overgaard M, Seifert T, Secher NH, Johansson PI, Meyer MAS, et al. Effect of heat stress on cardiac output and systemic vascular conductance during simulated hemorrhage to presyncope in young men. AJP Hear Circ Physiol. 2012;302(8):H1756–61.
Chiesa ST, Trangmar SJ, González-Alonso J. Temperature and blood flow distribution in the human leg during passive heat stress. J Appl Physiol. 2016;120(9):1047–58.
Peters JK, Nishiyasu T, Mack GW. Reflex control of the cutaneous circulation during passive body core heating in humans. J Appl Physiol. 2000;88(5):1756–64.
Nelson MD, Altamirano-Diaz LA, Petersen SR, DeLorey DS, Stickland MK, Thompson RB, et al. Left ventricular systolic and diastolic function during tilt-table positioning and passive heat stress in humans. Am J Physiol Circ Physiol. 2011;301(2):H599–608.
Wyss CR, Brengelmann GL, Johnson JM, Rowell LB, Silverstein D. Altered control of skin blood flow at high skin and core temperatures. J Appl Physiol. 1975;38(5):839–45.
Gorman AJ, Proppe DW. Mechanisms producing tachycardia in conscious baboons during environmental heat stress. J Appl Physiol. 1984;56:441–6.
Stöhr EJ, González-Alonso J, Pearson J, Low DA, Ali L, Barker H, et al. Effects of graded heat stress on global left ventricular function and twist mechanics at rest and during exercise in healthy humans. Exp Physiol. 2011;96(2):114–24.
Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B, et al. Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol. 2008;586(1):293–301.
Keller DM, Low DA, Wingo JE, Brothers RM, Hastings J, Davis SL, et al. Acute volume expansion preserves orthostatic tolerance during whole-body heat stress in humans. J Physiol. 2009;587(5):1131–9.
Wilson TE, Brothers RM, Tollund C, Dawson EA, Nissen P, Yoshiga CC, et al. Effect of thermal stress on Frank-Starling relations in humans. J Physiol. 2009;587(13):3383–92.
Wilson TE, Tollund C, Yoshiga CC, Dawson EA, Nissen P, Secher NH, et al. Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans. J Physiol. 2007;585(1):279–85.
Brothers RM, Bhella PS, Shibata S, Wingo JE, Levine BD, Crandall CG. Cardiac systolic and diastolic function during whole body heat stress. Am J Physiol Circ Physiol. 2009;296(4):H1150–6.
Nelson MD, Haykowsky MJ, Petersen SR, DeLorey DS, Cheng-Baron J, Thompson RB. Increased left ventricular twist, untwisting rates, and suction maintain global diastolic function during passive heat stress in humans. Am J Physiol Circ Physiol. 2010;298(3):H930–7.
Brothers RM, Bhella PS, Shibata S, Wingo JE, Levine BD, Crandall CG. Cardiac systolic and diastolic function during whole body heat stress. Am J Physiol Heart Circ Physiol. 2009;296(4):H1150–6.
Rowell LB, Brengelmann GL, Blackmon JR, Murray JA. Redistribution of blood flow during sustained high skin temperature in resting man. J Appl Physiol. 1970;28(4):415–20.
Taylor WF, Johnson JM, Kosiba WA, Kwan CM. Graded cutaneous vascular responses to dynamic leg exercise. J Appl Physiol. 1988;64(5):1803–9.
Stephenson LA, Wenger CB, O’Donovan BH, Nadel ER. Circadian rhythm in sweating and cutaneous blood flow. Am J Phys. 1984;246(3):R321–4.
Crandall CG, Stephens DP, Johnson JM. Muscle metaboreceptor modulation of cutaneous active vasodilation. Med Sci Sports Exerc. 1998;30(4):490–6.
Jackson DN, Kenny GP. Upright LBPP application attenuates elevated postexercise resting thresholds for cutaneous vasodilation and sweating. J Appl Physiol. 2003;95(1):121–8.
Kellogg DL Jr, Liu Y, Kosiba IF, O’Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol. 1999;86(4):1185–90.
Kellogg DL, Zhao JL, Wu Y. Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. Am J Physiol Heart Circ Physiol. 2008;295(1):H123–9.
Johnson JM, Kellogg DL Jr. Local thermal control of the human cutaneous circulation. J Appl Physiol. 2010;109(4):1229–38.
Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol. 2001;91(4):1619–26.
Black MA, Green DJ, Cable NT. Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels. J Physiol. 2008;586(14):3511–24.
Taylor WF, Johnson JM, O’Leary D, Park MK. Effect of high local temperature on reflex cutaneous vasodilation. J Appl Physiol. 1984;57(1):191–6.
Johnson JM, Brengelmann GL, Rowell LB. Interactions between local and reflex influences on human forearm skin blood flow. J Appl Physiol. 1976;41(6):826–31.
Detry JM, Brengelmann GL, Rowell LB, Wyss C. Skin and muscle components of forearm blood flow in directly heated resting man. J Appl Physiol. 1972;32(4):506–11.
Hales JRS, Rowell LB, King RB. Regional distribution of blood flow in awake heat-stressed baboons. Am J Phys. 1979;237(6):H705–12.
Abramson DI, Kahn A, Tuck S Jr, Turman GA, Rejal H, Fleischer CJ. Relationship between a range of tissue temperature and local oxygen uptake in the human forearm. I. Changes observed under resting conditions. J Clin Invest. 1958;37(7):1031–8.
Kalsi KK, Chiesa ST, Trangmar SJ, Ali L, Lotlikar MD, González-Alonso J. Mechanisms for the control of local tissue blood flow during thermal interventions: influence of temperature-dependent ATP release from human blood and endothelial cells. Exp Physiol. 2017;102(2):228–44.
Wyper DJ, McNiven DR. The effect of microwave therapy upon muscle blood flow in man. Br J Sports Med. 1976;10(1):19–21.
Lehmann JF, Guy AW, Stonebridge JB, DeLateur BJ. Evaluation of a therapeutic direct-contact 915-MHz microwave applicator for effective deep-tissue heating in humans. IEEE Trans Microw Theory Tech. 1978;26(8):556–63.
Sekins KM, Lehmann JF, Esselman P, Dundore D, Emery AF, DeLateur BJ, et al. Local muscle blood flow and temperature responses to 915MHz diathermy as simultaneously measured and numerically predicted. Arch Phys Med Rehabil. 1984;65(1):1–7.
Song CW. Effect of local hyperthermia on blood flow and microenvironment: a review. Cancer Res. 1984;44(S10):4721.
Giombini A, Giovannini V, Di Cesare A, Pacetti P, Ichinoseki-Sekine N, Shiraishi M, et al. Hyperthermia induced by microwave diathermy in the management of muscle and tendon injuries. Br Med Bull. 2007;83(1):379–96.
Akyürekli D, Gerig LH, Raaphorst GP. Changes in muscle blood flow distribution during hyperthermia. Int J Hyperth. 1997;13(5):481–96.
Okada K, Yamaguchi T, Minowa K, Inoue N. The influence of hot pack therapy on the blood flow in masseter muscles. J Oral Rehabil. 2005;32(7):480–6.
Keller DM, Sander M, Stallknecht B, Crandall CG. α-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. J Physiol. 2010;588(19):3799–808.
Binzoni T, Tchernin D, Richiardi J, Van De Ville D, Hyacinthe J-N. Haemodynamic responses to temperature changes of human skeletal muscle studied by laser-Doppler flowmetry. Physiol Meas. 2012;33(7):1181–97.
Chiesa ST, Trangmar SJ, Kalsi KK, Rakobowchuk M, Banker DS, Lotlikar MD, et al. Local temperature-sensitive mechanisms are important mediators of limb tissue hyperemia in the heat-stressed human during rest and small muscle mass exercise. Am J Physiol Circ Physiol. 2015;309:H369–80.
Heinonen I, Brothers RM, Kemppainen J, Knuuti J, Kalliokoski KK, Crandall CG. Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow. J Appl Physiol. 2011;111(3):818–24.
Ives SJ, Andtbacka RH, Kwon SH, Shiu YT, Ruan T, Noyes RD, et al. Heat and alpha1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide. J Appl Physiol. 2012;113(11):1690–8.
Kalsi KK, González-Alonso J. Temperature-dependent release of ATP from human erythrocytes: mechanism for the control of local tissue perfusion. Exp Physiol. 2012;97(3):419–32.
Ives SJ, Andtbacka RHI, Noyes RD, McDaniel J, Amann M, Witman MAH, et al. Human skeletal muscle feed arteries studied in vitro: the effect of temperature on α1-adrenergic responsiveness. Exp Physiol. 2011;96(9):907–18.
Heinonen I, Wendelin-Saarenhovi M, Kaskinoro K, Knuuti J, Scheinin M, Kalliokoski KK. Inhibition of alpha-adrenergic tone disturbs the distribution of blood flow in the exercising human limb. Am J Physiol Circ Physiol. 2013;305(2):H163–72.
Kluess HA, Buckwalter JB, Hamann JJ, Clifford PS. Elevated temperature decreases sensitivity of P2X purinergic receptors in skeletal muscle arteries. J Appl Physiol. 2005;99(3):995–8.
Fujii N, McGinn R, Halili L, Singh MS, Kondo N, Kenny GP. Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase? J Physiol. 2015;593(11):2515–25.
González-Alonso J, Olsen DB, Saltin B. Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery role of circulating ATP. Circ Res. 2002;91(11):1046–55.
González-Alonso J, Mortensen SP, Jeppesen TD, Ali L, Barker H, Damsgaard R, et al. Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function. J Physiol. 2008;586(9):2405–17.
Rosenmeier JB, Hansen J, González-Alonso J. Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J Physiol. 2004;558(1):351–65.
Rosenmeier JB, Yegutkin GG, González-Alonso J. Activation of ATP/UTP-selective receptors increases blood flow and blunts sympathetic vasoconstriction in human skeletal muscle. J Physiol. 2008;586(20):4993–5002.
González-Alonso J, Calbet JAL, Boushel R, Helge JW, Søndergaard H, Munch-Andersen T, et al. Blood temperature and perfusion to exercising and non-exercising human limbs. Exp Physiol. 2015;100(10):1118–31.
Rowell LB, Detry JR, Profant GR, Wyss C. Splanchnic vasoconstriction in hyperthermic man--role of falling blood pressure. J Appl Physiol. 1971;31(6):864–9.
Bain AR, Smith KJ, Lewis NC, Foster GE, Wildfong KW, Willie CK, et al. Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow. J Appl Physiol. 2013;115(5):653–9.
Willie CK, Tzeng Y-C, Fisher JA, Ainslie PN. Integrative regulation of human brain blood flow. J Physiol. 2014;592(5):841–59.
Miyazawa T, Horiuchi M, Ichikawa D, Subudhi AW, Sugawara J, Ogoh S. Face cooling with mist water increases cerebral blood flow during exercise: effect of changes in facial skin blood flow. Front Physiol. 2012;3:308.
González-Alonso J, Calbet JAL. Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans. Circulation. 2003;107(6):824–30.
González-Alonso J, Dalsgaard MK, Osada T, Volianitis S, Dawson EA, Yoshiga CC, et al. Brain and central haemodynamics and oxygenation during maximal exercise in humans. J Physiol. 2004;557(1):331–42.
Trangmar SJ, González-Alonso J. New insights into the impact of dehydration on blood flow and metabolism during exercise. Exerc Sport Sci Rev. 2017;45(3):146–53.
González-Alonso J, Quistorff B, Krustrup P, Bangsbo J, Saltin B. Heat production in human skeletal muscle at the onset of intense dynamic exercise. J Physiol. 2000;524(2):603–15.
Nybo L, Nielsen B. Middle cerebral artery blood velocity is reduced with hyperthermia during prolonged exercise in humans. J Physiol. 2001;534(1):279–86.
Fujii N, Honda Y, Hayashi K, Soya H, Kondo N, Nishiyasu T. Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exercise. J Appl Physiol. 2008;104(4):998–1005.
Hayashi K, Honda Y, Ogawa T, Kondo N, Nishiyasu T. Relationship between ventilatory response and body temperature during prolonged submaximal exercise. J Appl Physiol. 2006;100(2):414–20.
Keiser S, Flück D, Stravs A, Hüppin F, Lundby C. Restoring heat stress-associated reduction in middle cerebral artery velocity does not reduce fatigue in the heat. Scand J Med Sci Sports. 2015;25(1):145–53.
Forster HV, Haouzi P, Dempsey JA. Control of breathing during exercise. Compr Physiol. 2012;2(1):743–77.
Ferguson RA, Krustrup P, Kjaer M, Mohr M, Ball D, Bangsbo J. Effect of temperature on skeletal muscle energy turnover during dynamic knee-extensor exercise in humans. J Appl Physiol. 2006;101(1):47–52.
Nielsen B, Savard G, Richter EA, Hargreaves M, Saltin B. Muscle blood flow and muscle metabolism during exercise and heat stress. J Appl Physiol. 1990;69(3):1040–6.
Nielsen B, Hales JR, Strange S, Christensen NJ, Warberg J, Saltin B. Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment. J Physiol. 1993;460(1):467–85.
Nielsen B, Strange S, Christensen NJ, Warberg J, Saltin B. Acute and adaptive responses in humans to exercise in a warm, humid environment. Pflugers Arch - Eur J Physiol. 1997;434(1):49–56.
Trangmar SJ, Chiesa ST, Kalsi KK, Secher NH, González-Alonso J. Whole body hyperthermia, but not skin hyperthermia, accelerates brain and locomotor limb circulatory strain and impairs exercise capacity in humans. Physiol Rep. 2017;5(1):e13108.
Kellogg DL, Johnson JM, Kenney WL, Pergola PE, Kosiba WA. Mechanisms of control of skin blood flow during prolonged exercise in humans. Am J Physiol Circ Physiol. 1993;265(2):562–8.
Shibasaki M, Wilson TE, Crandall CG. Neural control and mechanisms of eccrine sweating during heat stress and exercise. J Appl Physiol. 2006;100:1692–701.
González-Alonso J, Calbet JA, Nielsen B. Metabolic and thermodynamic responses to dehydration-induced reductions in muscle blood flow in exercising humans. J Physiol. 1999;520:577–89.
Calbet JA, González-Alonso J, Helge JW, Sondergaard H, Munch-Andersen T, Boushel R, et al. Cardiac output and leg and arm blood flow during incremental exercise to exhaustion on the cycle ergometer. J Appl Physiol. 2007;103(3):969–78.
González-Alonso J, Teller C, Andersen SL, Jensen FB, Hyldig T, Nielsen B. Influence of body temperature on the development of fatigue during prolonged exercise in the heat. J Appl Physiol. 1999;86(3):1032–9.
Nybo L, Møller K, Volianitis S, Nielsen B, Secher NH, Moller K, et al. Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol. 2002;93(1):58–64.
Rowell LB. Human circulation: regulation during physical stress. Oxford: Oxford University Press; 1986. p. 416.
Rowell LB. Cardiovascular adjustments to thermal stress. Comprehensive physiology. Hoboken: Wiley; 2011.
Trinity JD, Pahnke MD, Lee JF, Coyle EF. Interaction of hyperthermia and heart rate on stroke. J Appl Physiol. 2011;111(3):891–7.
Buxton RB, Frank LR. A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab. 1997;17(1):64–72.
Secher NH, Seifert T, Van Lieshout JJ. Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol. 2008;104(1):306–14.
Hellstrom G, Fischer-Colbrie W, Wahlgren NG, Jogestrand T. Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol. 1996;81(1):413–8.
Sato K, Ogoh S, Hirasawa A, Oue A, Sadamoto T. The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans. J Physiol. 2011;589(11):2847–56.
Trangmar SJ, Chiesa ST, Stock CG, Kalsi KK, Secher NH, González-Alonso J. Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans. J Physiol. 2014;592(14):3143–60.
Trangmar SJ, Chiesa ST, Llodio I, Garcia B, Kalsi KK, Secher NH, et al. Dehydration accelerates reductions in cerebral blood flow during prolonged exercise in the heat without compromising brain metabolism. Am J Physiol Heart Circ Physiol. 2015;309(9):H1598–607.
Périard JD, Racinais S. Heat stress exacerbates the reduction in middle cerebral artery blood velocity during prolonged self-paced exercise. Scand J Med Sci Sports. 2015;25(S1):135–44.
Moraine JJ, Lamotte M, Berré J, Niset G, Leduc A, Naeijel R. Relationship of middle cerebral artery blood flow velocity to intensity during dynamic exercise in normal subjects. Eur J Appl Physiol Occup Physiol. 1993;67(1):35–8.
Sato K, Oue A, Yoneya M, Sadamoto T, Ogoh S. Heat stress redistributes blood flow in the arteries of the brain during dynamic exercise. J Appl Physiol. 2016;120(7):766–73.