Derivation of Neural Stem Cells from the Developing and Adult Human Brain

  • Claire M. Kelly
  • Maeve A. CaldwellEmail author
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 66)


Neural stem cells isolated from the developing and adult brain are an ideal source of cells for use in clinical applications such as cell replacement therapy. The clear advantage of these cells over the more commonly utilised embryonic and pluripotent stem cells is that they are already neurally committed. Of particular importance is the fact that these cells don’t require the same level of in vitro culture that can be cost and labour intensive. Foetal neural stem cells can be readily derived from the foetal brain and expand in culture over time. Similarly, adult stem cells have been explored for their potential in vitro and in vivo animal models. In this chapter we identify the progress made in developing these cells as well as the advantages of taking them forward for clinical use.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Biomedical Science, Cardiff School of Health SciencesCardiff Metropolitan UniversityCardiffUK
  2. 2.Trinity College Institute for Neuroscience, Trinity College DublinDublinIreland

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