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Vulnerability to Nontuberculous Mycobacterial Lung Disease or Systemic Infection Due to Genetic/Heritable Disorders

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Nontuberculous Mycobacterial Disease

Part of the book series: Respiratory Medicine ((RM))

Abstract

Nontuberculous mycobacteria (NTM) are ubiquitous in the natural and man-made environments, and yet human disease due to NTM is not widely pervasive. Presuming that human exposure to NTM is common, it suggests that NTM are relatively avirulent and that established infection resulting in disease occurs mostly in those who are innately susceptible. Most cases of NTM-LD and essentially all of extrapulmonary visceral/disseminated NTM disease occur in individuals with identifiable risk factors. While acquired disorders may predispose to either isolated NTM-LD or extrapulmonary visceral/disseminated NTM disease, this review focuses on genetic/heritable causes of these two forms of NTM disease.

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Authors and Affiliations

  1. Pulmonary Section, Denver Veterans Affairs Medical Center, Denver, CO, USA

    Edward D. Chan

  2. Program in Cell Biology and Department of Academic Affairs, National Jewish Health, Denver, CO, USA

    Edward D. Chan

  3. Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Edward D. Chan

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  1. Professor of Medicine, University of Texas Health Science Center, Tyler, TX, USA

    David E. Griffith

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Chan, E.D. (2019). Vulnerability to Nontuberculous Mycobacterial Lung Disease or Systemic Infection Due to Genetic/Heritable Disorders. In: Griffith, D. (eds) Nontuberculous Mycobacterial Disease. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-93473-0_4

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