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Hypertension and Heart Failure pp 135–154Cite as

Role of Central Blood Pressure and Arterial Stiffening

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Part of the Updates in Hypertension and Cardiovascular Protection book series (UHCP)

Abstract

Two concepts have gained a growing audience these last years: the pressure amplification between central and peripheral arteries in response to arterial stiffening and pressure wave reflection and the left ventricle (LV)-arterial system coupling in heart failure (notably with preserved ejection fraction also referred to as diastolic heart failure) as arterial stiffening can result in impaired active ventricular relaxation and passive ventricular compliance. The aims of this chapter are (1) to detail the haemodynamic characteristics of the arterial circulation in order to explain why it is important to measure arterial stiffness and central BP in hypertensive patients, (2) to describe the various non-invasive methods currently available to measure arterial stiffness and central BP and (3) to discuss how arterial stiffness and central BP measurements can help understanding the relationship between hypertension and heart failure.

Keywords

  • Arterial stiffness
  • Central blood pressure
  • Heart failure
  • Large artery
  • Organ damage
  • Wave reflection

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Acknowledgements

This work was supported by INSERM, Assistance Publique—Hopitaux de Paris, and Paris Descartes University (SL).

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Authors and Affiliations

  1. Department of Pharmacology, Université Paris-Descartes, Assistance-Publique Hôpitaux de Paris, INSERM-PARCC U970, and Hôpital Européen Georges Pompidou, Paris, France

    Stéphane Laurent & Pierre Boutouyrie

  2. Université Paris-Descartes, Assistance-Publique Hôpitaux de Paris, INSERM-PARCC U970, and Clinical Investigation Center, Hôpital Européen Georges Pompidou, Paris, France

    Jean-Sébastien Hulot

Authors
  1. Stéphane Laurent
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  2. Jean-Sébastien Hulot
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  3. Pierre Boutouyrie
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Corresponding author

Correspondence to Stéphane Laurent .

Editor information

Editors and Affiliations

  1. Carol Davila University of Medicine and Pharmacy Bucharest and Cardiology Department, Emergency Clinical Hospital, Bucharest, Romania

    Maria Dorobantu

  2. University of Milano-Bicocca, Milano, Italy

    Giuseppe Mancia & Guido Grassi & 

  3. Department of Pharmacology, Toxicology and Clinical Psychopharmacology Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Victor Voicu

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Laurent, S., Hulot, JS., Boutouyrie, P. (2019). Role of Central Blood Pressure and Arterial Stiffening. In: Dorobantu, M., Mancia, G., Grassi, G., Voicu, V. (eds) Hypertension and Heart Failure. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-93320-7_9

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  • DOI: https://doi.org/10.1007/978-3-319-93320-7_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-93319-1

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