Myoepithelial Lesions and Tumors of the Breast

  • Michael Z. GilcreaseEmail author


A number of conditions can lead to metaplastic or proliferative changes in the myoepithelial cell layer of the breast, resulting in a variety of benign and malignant myoepithelial cell lesions. Nonneoplastic myoepithelial lesions are common, often observed as an incidental finding in the breast, and include myoepithelial hyperplasia, sclerosing adenosis, and collagenous spherulosis. Myoepithelial neoplasms are uncommon and include adenomyoepithelioma, malignant adenomyoepithelioma, and myoepithelial carcinoma.


Sclerosing adenosis Collagenous spherulosis Adenomyoepithelioma Malignant myoepithelioma Myoepithelial carcinoma 


  1. 1.
    Deugnier MA, Teuliere J, Faraldo MM, Thiery JP, Glukhova MA. The importance of being a myoepithelial cell. Breast Cancer Res. 2002;4(6):224–30.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Clarke C, Sandle J, Lakhani SR. Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation. J Mammary Gland Biol Neoplasia. 2005;10(3):273–80.CrossRefPubMedGoogle Scholar
  3. 3.
    Gudjonsson T, Adriance MC, Sternlicht MD, Petersen OW, Bissell MJ. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia. 2005;10(3):261–72.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol. 1970;53:161–220.CrossRefPubMedGoogle Scholar
  5. 5.
    Yaziji H, Gown AM, Sneige N. Detection of stromal invasion in breast cancer: the myoepithelial markers. Adv Anat Pathol. 2000;7(2):100–9.CrossRefPubMedGoogle Scholar
  6. 6.
    Dewar R, Fadare O, Gilmore H, Gown AM. Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology. Arch Pathol Lab Med. 2011;135(4):422–9.PubMedGoogle Scholar
  7. 7.
    Corben AD, Lerwill MF. Use of myoepithelial cell markers in the differential diagnosis of benign, in situ, and invasive lesions of the breast. Surg Pathol Clin. 2009;2(2):351–73.CrossRefPubMedGoogle Scholar
  8. 8.
    Eusebi V, Cunsolo A, Fedeli F, Severi B, Scarani P. Benign smooth muscle cell metaplasia in breast. Tumori. 1980;66(5):643–53.CrossRefPubMedGoogle Scholar
  9. 9.
    Daroca PJ Jr, Reed RJ, Love GL, Kraus SD. Myoid hamartomas of the breast. Hum Pathol. 1985;16(3):212–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Shepstone BJ, Wells CA, Berry AR, Ferguson JD. Mammographic appearance and histopathological description of a muscular hamartoma of the breast. Br J Radiol. 1985;58(689):459–61.CrossRefPubMedGoogle Scholar
  11. 11.
    Raju GC. The histological and immunohistochemical evidence of squamous metaplasia from the myoepithelial cells in the breast. Histopathology. 1990;17(3):272–5.CrossRefPubMedGoogle Scholar
  12. 12.
    Tavassoli FA. Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 1991;15(6):554–68.CrossRefPubMedGoogle Scholar
  13. 13.
    Urban JA, Adair FE. Sclerosing adenosis. Cancer. 1949;2(4):625–34.CrossRefPubMedGoogle Scholar
  14. 14.
    Foote FW, Stewart FW. Comparative studies of cancerous versus noncancerous breasts. Ann Surg. 1945;121(2):197–222.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    MacErlean DP, Nathan BE. Calcification in sclerosing adenosis simulating malignant breast calcification. Br J Radiol. 1972;45(540):944–5.CrossRefPubMedGoogle Scholar
  16. 16.
    Nielsen BB. Adenosis tumour of the breast—a clinicopathological investigation of 27 cases. Histopathology. 1987;11(12):1259–75.CrossRefPubMedGoogle Scholar
  17. 17.
    Jensen RA, Page DL, Dupont WD, Rogers LW. Invasive breast cancer risk in women with sclerosing adenosis. Cancer. 1989;64(10):1977–83.CrossRefPubMedGoogle Scholar
  18. 18.
    Davies JD. Neural invasion in benign mammary dysplasia. J Pathol. 1973;109(3):225–31.CrossRefPubMedGoogle Scholar
  19. 19.
    Fechner RE. Lobular carcinoma in situ in sclerosing adenosis. A potential source of confusion with invasive carcinoma. Am J Surg Pathol. 1981;5(3):233–9.CrossRefPubMedGoogle Scholar
  20. 20.
    Eusebi V, Collina G, Bussolati G. Carcinoma in situ in sclerosing adenosis of the breast: an immunocytochemical study. Semin Diagn Pathol. 1989;6(2):146–52.PubMedGoogle Scholar
  21. 21.
    Resetkova E, Albarracin C, Sneige N. Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. Am J Surg Pathol. 2006;30(1):20–7.CrossRefPubMedGoogle Scholar
  22. 22.
    Clement PB, Young RH, Azzopardi JG. Collagenous spherulosis of the breast. Am J Surg Pathol. 1987;11(6):411–7.CrossRefPubMedGoogle Scholar
  23. 23.
    Grignon DJ, Ro JY, Mackay BN, Ordonez NG, Ayala AG. Collagenous spherulosis of the breast. Immunohistochemical and ultrastructural studies. Am J Clin Pathol. 1989;91(4):386–92.CrossRefPubMedGoogle Scholar
  24. 24.
    Rosen PP. Adenomyoepithelioma of the breast. Hum Pathol. 1987;18(12):1232–7.CrossRefPubMedGoogle Scholar
  25. 25.
    Loose JH, Patchefsky AS, Hollander IJ, Lavin LS, Cooper HS, Katz SM. Adenomyoepithelioma of the breast. A spectrum of biologic behavior. Am J Surg Pathol. 1992;16(9):868–76.CrossRefPubMedGoogle Scholar
  26. 26.
    Cai RZ, Tan PH. Adenomyoepithelioma of the breast with squamous and sebaceous metaplasia. Pathology. 2005;37(6):557–9.CrossRefPubMedGoogle Scholar
  27. 27.
    Young RH, Clement PB. Adenomyoepithelioma of the breast. A report of three cases and review of the literature. Am J Clin Pathol. 1988;89(3):308–14.CrossRefPubMedGoogle Scholar
  28. 28.
    Pauwels C, De Potter C. Adenomyoepithelioma of the breast with features of malignancy. Histopathology. 1994;24(1):94–6.CrossRefPubMedGoogle Scholar
  29. 29.
    Rasbridge SA, Millis RR. Adenomyoepithelioma of the breast with malignant features. Virchows Arch. 1998;432(2):123–30.CrossRefPubMedGoogle Scholar
  30. 30.
    Ahmed AA, Heller DS. Malignant adenomyoepithelioma of the breast with malignant proliferation of epithelial and myoepithelial elements: a case report and review of the literature. Arch Pathol Lab Med. 2000;124(4):632–6.PubMedGoogle Scholar
  31. 31.
    Fan F, Smith W, Wang X, Jewell W, Thomas PA, Tawfik O. Myoepithelial carcinoma of the breast arising in an adenomyoepithelioma: mammographic, ultrasound and histologic features. Breast J. 2007;13(2):203–4.CrossRefPubMedGoogle Scholar
  32. 32.
    Noel JC, Simon P, Aguilar SF. Malignant myoepithelioma arising in cystic adenomyoepithelioma. Breast J. 2006;12(4):386.CrossRefPubMedGoogle Scholar
  33. 33.
    Simpson RH, Cope N, Skalova A, Michal M. Malignant adenomyoepithelioma of the breast with mixed osteogenic, spindle cell, and carcinomatous differentiation. Am J Surg Pathol. 1998;22(5):631–6.CrossRefPubMedGoogle Scholar
  34. 34.
    Chen PC, Chen CK, Nicastri AD, Wait RB. Myoepithelial carcinoma of the breast with distant metastasis and accompanied by adenomyoepitheliomas. Histopathology. 1994;24(6):543–8.CrossRefPubMedGoogle Scholar
  35. 35.
    Michal M, Baumruk L, Burger J, Manhalova M. Adenomyoepithelioma of the breast with undifferentiated carcinoma component. Histopathology. 1994;24(3):274–6.CrossRefPubMedGoogle Scholar
  36. 36.
    Behranwala KA, Nasiri N, A'Hern R, Gui GP. Clinical presentation and long-term outcome of pure myoepithelial carcinoma of the breast. Eur J Surg Oncol. 2004;30(4):357–61.CrossRefPubMedGoogle Scholar
  37. 37.
    Buza N, Zekry N, Charpin C, Tavassoli FA. Myoepithelial carcinoma of the breast: a clinicopathological and immunohistochemical study of 15 diagnostically challenging cases. Virchows Arch. 2010;457(3):337–45.CrossRefPubMedGoogle Scholar
  38. 38.
    Tan PH, Ellis IO. Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO classification of tumours of the breast 2012. J Clin Pathol. 2013;66(6):465–70.CrossRefPubMedGoogle Scholar
  39. 39.
    Moulder S, Moroney J, Helgason T, Wheler J, Booser D, Albarracin C, et al. Responses to liposomal doxorubicin, bevacizumab, and temsirolimus in metaplastic carcinoma of the breast: biologic rationale and implications for stem-cell research in breast cancer. J Clin Oncol. 2011;29(19):e572–5.CrossRefPubMedGoogle Scholar
  40. 40.
    Moulder S, Helgason T, Janku F, Wheler J, Moroney J, Booser D, et al. Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer. Ann Oncol. 2015;26(7):1346–52.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pathology and Laboratory Medicine, Department of PathologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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