Skip to main content

Pharmaceutical Care and Cardiovascular Diseases

  • Chapter
  • First Online:
  • 2030 Accesses

Abstract

Cardiovascular diseases (CVDs) are often accompanied with comorbidities and, therefore, with multiple drug regimens. Drug-related morbidity and mortality due to drug-related problems (DRPs) represent a serious problem in these patients. Pharmacists’ intervention can detect and solve or prevent DRPs. However, DRPs in CVDs are currently not a validated surrogate outcome. Nevertheless, suggested interventions are medication reconciliation and reviews, patient education and counseling (to improve self-care and medication adherence), additional written information (medication plan) and pillboxes (weekly dosing aids) to improve adherence, and monitoring of clinical parameters, among others. Apart from hypertension and CVD risk reduction, randomized controlled trials (RCTs) with robust designs, studying large populations, adequate follow-up periods, and sufficiently powered to detect clinical relevant differences in endpoints are needed. The evidence gained will provide standards for the interventions and outcome measures, both to compare studies and approaches to implement them reimbursed in daily pharmaceutical practice.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. World Health Organisation (WHO). [cited 21 July 2017]. Available from http://www.who.int/.

  2. European Society of Cardiology (ESC). [cited 21 July 2017]. Available from https://www.escardio.org/Guidelines.

  3. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146–603.

    Article  Google Scholar 

  4. McAlister FA, Stewart S, Ferrua S, McMurray JJJV. Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials. J Am Coll Cardiol. 2004;44(4):810–9.

    PubMed  Google Scholar 

  5. Abdela OA, Bhagavathula AS, Getachew H, Kelifa Y. Risk factors for developing drug-related problems in patients with cardiovascular diseases attending Gondar University Hospital, Ethiopia. J Pharm Bioallied Sci. 2016;8(4):289–95.

    Article  CAS  Google Scholar 

  6. Gastelurrutia P, Benrimoj SI, Espejo J, Tuneu L, Mangues MA, Bayes-Genis A. Negative clinical outcomes associated with drug-related problems in heart failure (HF) outpatients: impact of a pharmacist in a multidisciplinary HF clinic. J Card Fail. 2011;17(3):217–23.

    Article  Google Scholar 

  7. Tsuyuki RT, Al Hamarneh YN, Jones CA, Hemmelgarn BR. The effectiveness of pharmacist interventions on cardiovascular risk: the multicenter randomized controlled RxEACH trial. J Am Coll Cardiol. 2016;67(24):2846–54.

    Article  Google Scholar 

  8. Santschi V, Chiolero A, Burnand B, Colosimo AL, Paradis G. Impact of pharmacist care in the management of cardiovascular disease risk factors: a systematic review and meta-analysis of randomized trials. Arch Intern Med. 2011;171(16):1441–53.

    Article  CAS  Google Scholar 

  9. Babar ZU, Kousar R, Murtaza G, Azhar S, Khan SA, Curley L. Randomized controlled trials covering pharmaceutical care and medicines management: A systematic review of literature. Res Social Adm Pharm. 2017, epub June 19.

    Google Scholar 

  10. Aguiar PM, Balisa-Rocha BJ, Brito GdC, da Silva WB, Machado M, Lyra DP. Pharmaceutical care in hypertensive patients: a systematic literature review. Res Social Adm Pharm. 2012;8(5):383–96.

    Article  Google Scholar 

  11. Santschi V, Chiolero A, Colosimo AL, Platt RW, Taffé P, Burnier M, et al. Improving blood pressure control through pharmacist interventions: a meta-analysis of randomized controlled trials. J Am Heart Assoc. 2014;3(2):e000718.

    Article  Google Scholar 

  12. Marra C, Johnston K, Santschi V, Tsuyuki RT. Cost-effectiveness of pharmacist care for managing hypertension in Canada. Can Pharm J. 2017;150(3):184–97.

    Article  Google Scholar 

  13. Cai H, Dai H, Hu Y, Yan X, Xu H. Pharmacist care and the management of coronary heart disease: a systematic review of randomized controlled trials. BMC Health Serv Res. 2013;13:461.

    Article  Google Scholar 

  14. Schulz M, Griese-Mammen N, Krueger K et al. Community pharmacists’ role in the ambulatory care of heart failure patients—a systematic review. In preparation.

    Google Scholar 

  15. Bleske BE, Dillman NO, Cornelius D, Ward JK, Burson SC, Diez HL, et al. Heart failure assessment at the community pharmacy level: a feasibility pilot study. J Am Pharm Assoc. 2014;54(6):634–41.

    Article  Google Scholar 

  16. Gwadry-Sridhar FH, Flintoft V, Lee DS, Lee H, Guyatt GH. A systematic review and meta- analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med. 2004;164(21):2315–20.

    Article  Google Scholar 

  17. Koshman SL, Charrois TL, Simpson SH, McAlister FA, Tsuyuki RT. Pharmacist care of patients with heart failure: a systematic review of randomized trials. Arch Intern Med. 2008;168(7):687–94.

    Article  Google Scholar 

  18. Adams KF Jr, Giblin EM, Pearce N, Patterson JH. Integrating new pharmacologic agents into heart failure care: role of heart failure practice guidelines in meeting the challenge. Pharmacotherapy 2017;37(6):645–56.

    Article  Google Scholar 

  19. Yancy CW, Januzzi JL Jr, Allen LA, Butler J, Davis LL, Fonarow GC, Ibrahim NE, Jessup M, Lindenfeld J, Maddox TM, Masoudi FA, Motiwala SR, Patterson JH, Walsh MN, Wasserman A. ACC expert consensus decision pathway for optimization of heart failure treatment: answers to 10 pivotal issues about heart failure with reduced ejection fraction: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Decision Pathways. J Am Coll Cardiol. 2018;71(2):201–30

    Google Scholar 

  20. Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF), eds. Nationale VersorgungsLeitlinie Chronische Herzinsuffizienz – Langfassung, 2. Auflage. 2017. Available from http://www.versorgungsleitlinien.de/themen/herzinsuffizienz. Last accessed 11 January 2018.

  21. Botermann L, Monzel K, Krueger K, Eickhoff C, Wachter A, Kloft C, Laufs U, Schulz M. Evaluating patients’ comprehensibility of a standardized medication plan. Eur J Clin Pharmacol. 2016;72(10):1229–37.

    Article  Google Scholar 

  22. Cholesterol Treatment Trialists’ Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267–78.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Martin Schulz .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Schulz, M., Krueger, K., Griese-Mammen, N., Tsuyuki, R. (2019). Pharmaceutical Care and Cardiovascular Diseases. In: Alves da Costa, F., van Mil, J., Alvarez-Risco, A. (eds) The Pharmacist Guide to Implementing Pharmaceutical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-92576-9_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-92576-9_29

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92575-2

  • Online ISBN: 978-3-319-92576-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics