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Bioactive Organoselenium Compounds and Therapeutic Perspectives

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New Frontiers in Organoselenium Compounds

Abstract

After 1984, when ebselen was tested as a mimetic of the key antioxidant enzyme glutathione peroxidase (GPx), a plethora of organoselenium compounds have been synthesized and tested for various pharmacological purposes. Here a brief overview of the most important achievements in bioactive organoselenium small molecules is given, with particular emphasis on the GPx-like as well as to the antiviral, antibacterial, antifungal, and antiprotozoal activities. While historical information is given to help contextualize the content, the most recent literature is comprehensively discussed.

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Authors and Affiliations

  1. CCQFA - LASOL, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil

    Eder João Lenardão

  2. Department of Pharmaceutical Sciences, Università degli Studi di Perugia, Perugia, Perugia, Italy

    Claudio Santi

  3. Section of Heterorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Łódź, Poland

    Luca Sancineto

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  1. Eder João Lenardão
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  2. Claudio Santi
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  3. Luca Sancineto
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Lenardão, E.J., Santi, C., Sancineto, L. (2018). Bioactive Organoselenium Compounds and Therapeutic Perspectives. In: New Frontiers in Organoselenium Compounds. Springer, Cham. https://doi.org/10.1007/978-3-319-92405-2_2

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