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Developmental Vascular Biology

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Evidence-Based Management of Head and Neck Vascular Anomalies

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Abstract

Our understanding of molecular processes governing embryonic vascular development has largely come from in vivo and ex vivo studies using model organisms (laboratory mice, chick, and xenopus embryos) and in vitro studies using human umbilical vein endothelial cells (HUVECs) or human embryonic stem cell lines (hESCs). ESCs have the capability of differentiating into any of the three primary germ layers (endoderm, mesoderm, or ectoderm). These investigations have been foundational to concepts governing our understanding of vascular anomaly development and treatment. At this time it is being determined how much animal and in vitro cellular biology is directly relevant to clinical care of vascular anomalies.

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Author information

Authors and Affiliations

  1. Division of Pediatric Otolaryngology, Seattle Children’s Hospital, Seattle, WA, USA

    Sheila N. Ganti PhD & Jonathan A. Perkins DO

  2. Center for Clinical and Translational Research, Seattle Children’s Research Institute, Seattle, WA, USA

    Sheila N. Ganti PhD

  3. Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA

    Mark W. Majesky PhD

  4. Departments of Pediatrics and Pathology, University of Washington, Seattle, WA, USA

    Mark W. Majesky PhD

  5. Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA

    Jonathan A. Perkins DO

  6. Center for Clinical and Translational Research, Seattle Children’s Research Institute, Seattle, WA, USA

    Jonathan A. Perkins DO

Authors
  1. Sheila N. Ganti PhD
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  2. Mark W. Majesky PhD
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  3. Jonathan A. Perkins DO
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Corresponding author

Correspondence to Jonathan A. Perkins DO .

Editor information

Editors and Affiliations

  1. Otolaryngology-Head and Neck Surgery, University of Washington, Seattle Children’s Hospital, Seattle, WA, USA

    Jonathan A. Perkins

  2. Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA

    Karthik Balakrishnan

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Ganti, S.N., Majesky, M.W., Perkins, J.A. (2018). Developmental Vascular Biology. In: Perkins, J., Balakrishnan, K. (eds) Evidence-Based Management of Head and Neck Vascular Anomalies. Springer, Cham. https://doi.org/10.1007/978-3-319-92306-2_4

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  • DOI: https://doi.org/10.1007/978-3-319-92306-2_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92305-5

  • Online ISBN: 978-3-319-92306-2

  • eBook Packages: MedicineMedicine (R0)

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