Abstract
The ventricular function curve relates cardiac output or stroke work with end-diastolic ventricular volume, end-diastolic ventricular pressure, or atrial filling pressure. Both Cardiac Output and Stroke Work are used as dependent variables. The Ventricular Function Curve is often obtained under conditions where the arterial load changes together with the ventricular filling. This means that a changed Ventricular Function Curve includes both cardiac and arterial changes. Thus while the Ventricular Function Curve can explain in vivo adjustments of the heart and the circulation, it is not a characterization of the heart alone.
The (maximal) time derivative of ventricular pressure before valve opening is a load-independent measure of ventricular contractility. The (maximal) negative value of the time derivative is a measure of muscle relaxation. Preload recruitable Stroke Work is considered load-independent, and its slope a measure of contractility
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Westerhof, N., Stergiopulos, N., Noble, M.I.M., Westerhof, B.E. (2019). Assessing Ventricular Function. In: Snapshots of Hemodynamics. Springer, Cham. https://doi.org/10.1007/978-3-319-91932-4_20
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DOI: https://doi.org/10.1007/978-3-319-91932-4_20
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