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Medication Overuse in Chronic Daily Headache

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Chronic Headache

Abstract

The frequent or regular intake of medication to treat acute headache episodes can lead to an increase in headache frequency and finally to a transition from episodic to chronic headache. Many patients with chronic headache take abortive medication on a daily basis. Medication overuse headache (MOH) is defined by the International Classification of Headache Disorders as a headache in patients with a pre-existing primary headache disorder (e.g., migraine or tension-type headache) occurring on ≥15 days per month for >3 months. Also, these primary headache disorders occur in association with overuse of medication for acute or symptomatic headache treatment. The prevalence of MOH in the general population is around 1%. MOH is more common in people with chronic migraine and chronic daily headache than in patients with episodic migraine. The phenotype of the headache in MOH depends on the initial primary headache and the type of overused acute medication. Treatment of MOH occurs in three stages. First, we educate patients about the relationship between frequent intake of acute headache medication and MOH to reduce intake of acute medication. In a second step migraine prevention should be initiated in chronic migraine (topiramate or onabotulinumtoxinA in migraine) or amitriptyline in chronic tension-type headache. In patients who fail to cease overuse of overused medication with preventive therapy, then detoxification occurs on an outpatient basis or in a day hospital or inpatient setting, depending on severity and comorbidities. The success rate of treatment is around 50–70%, with higher relapse rates in patients with opioid overuse. Patient education and continuity of care in the follow-up period reduce relapse rates.

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References

  1. Diener HC, Holle D, Solbach K, Gaul C. Medication-overuse headache: risk factors, pathophysiology and management. Nat Rev Neurol. 2016;12(10):575–83.

    Article  PubMed  Google Scholar 

  2. Headache Classification Committee of the International Headache Society. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.

    Article  Google Scholar 

  3. Dichgans J, Diener HC, Gerber WD, Verspohl EJ, Kukiolka H, Kluck M. Analgetika-induzierter Dauerkopfschmerz. Dtsch med Wschr. 1984;109:369–73.

    Article  CAS  PubMed  Google Scholar 

  4. Horton BT, Peters GA. Clinical manifestations of excessive use of ergotamine preparations and management of withdrawal effect: report of 52 cases. Headache. 1963;3:214–26.

    Article  Google Scholar 

  5. Kaube H, May A, Diener HC, Pfaffenrath V. Sumatriptan misuse in daily chronic headache. BMJ. 1994;308:1573.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Diener HC, Limmroth V. Medication-overuse headache: a worldwide problem. Lancet Neurol. 2004;3:475–83.

    Article  PubMed  Google Scholar 

  7. Diener HC, Katsarava Z, Limmroth V. Headache attributed to a substance or its withdrawal. Handb Clin Neurol. 2010;97:589–99.

    Article  PubMed  Google Scholar 

  8. Abrams BM. Medication overuse headaches. Med Clin North Am. 2013;97(2):337–52.

    Article  PubMed  Google Scholar 

  9. Kristoffersen ES, Lundqvist C. Medication-overuse headache: epidemiology, diagnosis and treatment. Ther Adv Drug Saf. 2014;5(2):87–99.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Stovner LJ, Andree C. Prevalence of headache in Europe: a review for the Eurolight project. J Headache Pain. 2010;11(4):289–99.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Straube A, Pfaffenrath V, Ladwig KH, Meisinger C, Hoffmann W, Fendrich K, et al. Prevalence of chronic migraine and medication overuse headache in Germany–the German DMKG headache study. Cephalalgia. 2010;30(2):207–13.

    Article  CAS  PubMed  Google Scholar 

  12. Westergaard ML, Hansen EH, Glumer C, Olesen J, Jensen RH. Definitions of medication-overuse headache in population-based studies and their implications on prevalence estimates: a systematic review. Cephalalgia. 2014;34(6):409–25.

    Article  PubMed  Google Scholar 

  13. Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27(3):193–210.

    Article  PubMed  Google Scholar 

  14. Katsarava Z, Schneeweiss S, Kurth T, Kroener U, Fritsche G, Eikermann A, et al. Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology. 2004;62(5):788–90.

    Article  CAS  PubMed  Google Scholar 

  15. Limmroth V, Katsarava Z, Fritsche G, Przywara S, Diener H. Features of medication overuse headache following overuse of different acute headache drugs. Neurology. 2002;59:1011–4.

    Article  CAS  PubMed  Google Scholar 

  16. Creac'h C, Radat F, Mick G, Guegan-Massardier E, Giraud P, Guy N, et al. One or several types of triptan overuse headaches? Headache. 2009;49(4):519–28.

    Article  PubMed  Google Scholar 

  17. Bigal ME, Borucho S, Serrano D, Lipton RB. The acute treatment of episodic and chronic migraine in the USA. Cephalalgia. 2009;29(8):891–7.

    Article  CAS  PubMed  Google Scholar 

  18. Bigal ME, Lipton RB. Excessive acute migraine medication use and migraine progression. Neurology. 2008;71(22):1821–8.

    Article  CAS  PubMed  Google Scholar 

  19. Thorlund K, Sun-Edelstein C, Druyts E, Kanters S, Ebrahim S, Bhambri R, et al. Risk of medication overuse headache across classes of treatments for acute migraine. J Headache Pain. 2016;17(1):107.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Chai NC, Scher AI, Moghekar A, Bond DS, Peterlin BL. Obesity and headache: part I–a systematic review of the epidemiology of obesity and headache. Headache. 2014;54(2):219–34.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Zeeberg P, Olesen J, Jensen R. Discontinuation of medication overuse in headache patients: recovery of therapeutic responsiveness. Cephalalgia. 2006;26(10):1192–8.

    Article  CAS  PubMed  Google Scholar 

  22. Paemeleire K, Evers S, Goadsby PJ. Medication-overuse headache in patients with cluster headache. Curr Pain Headache Rep. 2008;12(2):122–7.

    Article  PubMed  Google Scholar 

  23. Lance F, Parkes C, Wilkinson M. Does analgesic abuse cause headache de novo? Headache. 1988;38:61–2.

    Article  Google Scholar 

  24. Bahra A, Walsh M, Menon S, Goadsby PJ. Does chronic daily headache arise de novo in association with regular use of analgesics? Headache. 2003;43:179–90.

    Article  PubMed  Google Scholar 

  25. Lance F, Parkes C, Wilkinson M. Does analgesic abuse cause headaches de novo? Headache. 1988;28(1):61–2.

    Article  CAS  PubMed  Google Scholar 

  26. Paemeleire K, Bahra A, Evers S, Matharu MS, Goadsby PJ. Medication-overuse headache in patients with cluster headache. Neurology. 2006;67(1):109–13.

    Article  CAS  PubMed  Google Scholar 

  27. Di Lorenzo C, Coppola G, Curra A, Grieco G, Santorelli FM, Lepre C, et al. Cortical response to somatosensory stimulation in medication overuse headache patients is influenced by angiotensin converting enzyme (ACE) I/D genetic polymorphism. Cephalalgia. 2012;32(16):1189–97.

    Article  PubMed  Google Scholar 

  28. Di Lorenzo C, Di Lorenzo G, Sances G, Ghiotto N, Guaschino E, Grieco GS, et al. Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. J Headache Pain. 2009;10(5):349–55.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Cargnin S, Viana M, Ghiotto N, Bianchi M, Sances G, Tassorelli C, et al. Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy. Eur J Neurol. 2014;21(7):989–95.

    Article  CAS  PubMed  Google Scholar 

  30. Srikiatkhachorn A, Anthony M. Serotonin receptor adaptation in patients with analgesic-induced headache. Cephalalgia. 1996;16(6):419–22.

    Article  CAS  PubMed  Google Scholar 

  31. Srikiatkhachorn A, Anthony M. Platelet serotonin in patients with analgesic-induced headache. Cephalalgia. 1996;16(6):423–6.

    Article  CAS  PubMed  Google Scholar 

  32. Srikiatkhachorn A, Puangniyom S, Govitrapong P. Plasticity of 5-HT serotonin receptor in patients with analgesic-induced transformed migraine. Headache. 1998;38(7):534–9.

    Article  CAS  PubMed  Google Scholar 

  33. Rossi C, Pini LA, Cupini ML, Calabresi P, Sarchielli P. Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels. Eur J Clin Pharmacol. 2008;64(1):1–8.

    Article  CAS  PubMed  Google Scholar 

  34. Cupini LM, Costa C, Sarchielli P, Bari M, Battista N, Eusebi P, et al. Degradation of endocannabinoids in chronic migraine and medication overuse headache. Neurobiol Dis. 2008;30(2):186–9.

    Article  CAS  PubMed  Google Scholar 

  35. Ayzenberg I, Obermann M, Nyhuis P, Gastpar M, Limmroth V, Diener HC, et al. Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures. Cephalalgia. 2006;26(9):1106–14.

    Article  CAS  PubMed  Google Scholar 

  36. Ferraro D, Vollono C, Miliucci R, Virdis D, De Armas L, Pazzaglia C, et al. Habituation to pain in "medication overuse headache": a CO2 laser-evoked potential study. Headache. 2012;52(5):792–807.

    Article  PubMed  Google Scholar 

  37. Riederer F, Marti M, Luechinger R, Lanzenberger R, von Meyenburg J, Gantenbein AR, et al. Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety. World J Biol Psychiatry. 2012;13(7):517–25.

    Article  PubMed  Google Scholar 

  38. Riederer F, Gantenbein AR, Marti M, Luechinger R, Kollias S, Sandor PS. Decrease of gray matter volume in the midbrain is associated with treatment response in medication-overuse headache: possible influence of orbitofrontal cortex. J Neurosci. 2013;33(39):15343–9.

    Article  CAS  PubMed  Google Scholar 

  39. Grazzi L, Chiapparini L, Ferraro S, Usai S, Andrasik F, Mandelli ML, et al. Chronic migraine with medication overuse pre-post withdrawal of symptomatic medication: clinical results and FMRI correlations. Headache. 2010;50(6):998–1004.

    Article  PubMed  Google Scholar 

  40. Ferraro S, Grazzi L, Mandelli ML, Aquino D, Di Fiore D, Usai S, et al. Pain processing in medication overuse headache: a functional magnetic resonance imaging (fMRI) study. Pain Med. 2012;13(2):255–62.

    Article  PubMed  Google Scholar 

  41. Sarchielli P, Corbelli I, Messina P, Cupini LM, Bernardi G, Bono G, et al. Psychopathological comorbidities in medication-overuse headache: a multicentre clinical study. Eur J Neurol. 2015;23(1):85–91.

    Article  PubMed  Google Scholar 

  42. Westergaard ML, Glumer C, Hansen EH, Jensen RH. Medication overuse, healthy lifestyle behaviour and stress in chronic headache: results from a population-based representative survey. Cephalalgia. 2016;36(1):15–28.

    Article  PubMed  Google Scholar 

  43. Hagen K, Linde M, Steiner TJ, Stovner LJ, Zwart JA. Risk factors for medication-overuse headache: an 11-year follow-up study. The Nord-Trondelag health studies. Pain. 2012;153(1):56–61.

    Article  PubMed  Google Scholar 

  44. Fritsche G, Frettloh J, Huppe M, Dlugaj M, Matatko N, Gaul C, et al. Prevention of medication overuse in patients with migraine. Pain. 2010;151(2):404–13.

    Article  PubMed  Google Scholar 

  45. Krymchantowski AV, Tepper SJ, Jevoux C, Valenca MM. Medication-overuse headache: differences between daily and near-daily headache patients. Brain Sci. 2016;6:3.

    Article  CAS  Google Scholar 

  46. Rossi P, Di Lorenzo C, Faroni J, Cesarino F, Nappi G. Advice alone vs. structured detoxification programmes for medication overuse headache: a prospective, randomized, open-label trial in transformed migraine patients with low medical needs. Cephalalgia. 2006;26(9):1097–105.

    Article  CAS  PubMed  Google Scholar 

  47. Rossi P, Faroni JV, Tassorelli C, Nappi G. Advice alone versus structured detoxification programmes for complicated medication overuse headache (MOH): a prospective, randomized, open-label trial. J Headache Pain. 2013;14:10.

    Article  PubMed  PubMed Central  Google Scholar 

  48. de Goffau MJ, Klaver AR, Willemsen MG, Bindels PJ, Verhagen AP. The effectiveness of treatments for patients with medication overuse headache; a systematic review and meta-analysis. J Pain. 2016;18(6):615–27.

    Article  CAS  PubMed  Google Scholar 

  49. Grande RB, Aaseth K, Benth JS, Lundqvist C, Russell MB. Reduction in medication-overuse headache after short information. The Akershus study of chronic headache. Eur J Neurol. 2011;18(1):129–37.

    Article  CAS  PubMed  Google Scholar 

  50. Kristoffersen ES, Straand J, Russell MB, Lundqvist C. Disability, anxiety and depression in patients with medication-overuse headache in primary care–the BIMOH study. Eur J Neurol. 2016;23(Suppl 1):28–35.

    Article  PubMed  Google Scholar 

  51. Krause SJ, Stillman MJ, Tepper DE, Zajac D. A prospective cohort study of outpatient interdisciplinary rehabilitation of chronic headache patients. Headache. 2017;57(3):428–40.

    Article  PubMed  Google Scholar 

  52. Diener HC, Bussone G, Van Oene JC, Lahaye M, Schwalen S, Goadsby PJ. Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia. 2007;27(7):814–23.

    Article  PubMed  Google Scholar 

  53. Silberstein SD, Lipton RB, Dodick DW, Freitag FG, Ramadan N, Mathew N, et al. Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. Headache. 2007;47(2):170–80.

    Article  PubMed  Google Scholar 

  54. Silberstein S, Lipton R, Dodick D, Freitag F, Mathew N, Brandes J, et al. Topiramate treatment of chronic migraine: a randomized, placebo-controlled trial of quality of life and other efficacy measures. Headache. 2009;49(8):1153–62.

    Article  PubMed  Google Scholar 

  55. Diener HC, Dodick DW, Goadsby PJ, Bigal ME, Bussone G, Silberstein SD, et al. Utility of topiramate for the treatment of patients with chronic migraine in the presence or absence of acute medication overuse. Cephalalgia. 2009;29(10):1021–7.

    Article  PubMed  Google Scholar 

  56. Silberstein SD. Topiramate in migraine prevention: a 2016 perspective. Headache. 2017;57(1):165–78.

    Article  PubMed  Google Scholar 

  57. Aurora SK, Dodick DW, Turkel CC, DeGryse RE, Silberstein SD, Lipton RB, et al. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia. 2010;30(7):793–803.

    Article  CAS  PubMed  Google Scholar 

  58. Diener HC, Dodick DW, Aurora SK, Turkel CC, DeGryse RE, Lipton RB, et al. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia. 2010;30(7):804–14.

    Article  CAS  PubMed  Google Scholar 

  59. Dodick DW, Turkel CC, DeGryse RE, Aurora SK, Silberstein SD, Lipton RB, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache. 2010;50(6):921–36.

    Article  PubMed  Google Scholar 

  60. Silberstein SD, Blumenfeld AM, Cady RK, Turner IM, Lipton RB, Diener HC, et al. OnabotulinumtoxinA for treatment of chronic migraine: PREEMPT 24-week pooled subgroup analysis of patients who had acute headache medication overuse at baseline. J Neurol Sci. 2013;331(1–2):48–56.

    Article  CAS  PubMed  Google Scholar 

  61. Chiang CC, Schwedt TJ, Wang SJ, Dodick DW. Treatment of medication-overuse headache: a systematic review. Cephalalgia. 2015;36(4):371–86.

    Article  PubMed  Google Scholar 

  62. Katsarava Z, Fritsche G, Muessig M, Diener HC, Limmroth V. Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology. 2001;57:1694–8.

    Article  CAS  PubMed  Google Scholar 

  63. Rabe K, Pageler L, Gaul C, Lampl C, Kraya T, Foerderreuther S, et al. Prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind, placebo-controlled study. Cephalalgia. 2013;33(3):202–7.

    Article  PubMed  Google Scholar 

  64. Boe MG, Mygland A, Salvesen R. Prednisolone does not reduce withdrawal headache: a randomized, double-blind study. Neurology. 2007;69(1):26–31.

    Article  CAS  PubMed  Google Scholar 

  65. Tassorelli C, Jensen R, Allena M, De Icco R, Sances G, Katsarava Z, et al. A consensus protocol for the management of medication-overuse headache: evaluation in a multicentric, multinational study. Cephalalgia. 2014;34(9):645–55.

    Article  PubMed  Google Scholar 

  66. Bendtsen L, Munksgaard S, Tassorelli C, Nappi G, Katsarava Z, Lainez M, et al. Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project). Cephalalgia. 2014;34(6):426–33.

    Article  CAS  PubMed  Google Scholar 

  67. Krymchantowski AV, Tepper SJ, Jevoux C, Valenca M. Medication-overuse headache: protocols and outcomes in 149 consecutive patients in a tertiary Brazilian headache center. Headache. 2017;57(1):87–96.

    Article  PubMed  Google Scholar 

  68. Cady R, Nett R, Dexter K, Freitag F, Beach ME, Manley HR. Treatment of chronic migraine: a 3-month comparator study of naproxen sodium vs SumaRT/nap. Headache. 2014;54(1):80–93.

    Article  PubMed  Google Scholar 

  69. Hautaniemi T, Petrenko N, Skorinkin A, Giniatullin R. The inhibitory action of the antimigraine nonsteroidal anti-inflammatory drug naproxen on P2X3 receptor-mediated responses in rat trigeminal neurons. Neuroscience. 2012;209:32–8.

    Article  CAS  PubMed  Google Scholar 

  70. Smith TR. Low-dose Tizanidine with nonsteroidal anti-inflammatory drugs for detoxification from analgesic rebound headache. Headache. 2002;42:175–7.

    Article  PubMed  Google Scholar 

  71. Silberstein SD, Schulman EA, McFaden HM. Repetitive intravenous DHE in the treatment of refractory headache. Headache. 1990;30:334–9.

    Article  CAS  PubMed  Google Scholar 

  72. Saper JR, Silberstein S, Dodick D, Rapoport A. DHE in the pharmacotherapy of migraine: potential for a larger role. Headache. 2006;46(Suppl 4):S212–20.

    Article  PubMed  Google Scholar 

  73. Eller M, Gelfand AA, Riggins NY, Shiboski S, Schankin C, Goadsby PJ. Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome. Neurology. 2016;86(9):856–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Freitag FG, Lake A 3rd, Lipton R, Cady R, Diamond S, Silberstein S, et al. Inpatient treatment of headache: an evidence-based assessment. Headache. 2004;44(4):342–60.

    Article  PubMed  Google Scholar 

  75. Relja G, Granato A, Bratina A, Antonello RM, Zorzon M. Outcome of medication overuse headache after abrupt in-patient withdrawal. Cephalalgia. 2006;26(5):589–95.

    Article  CAS  PubMed  Google Scholar 

  76. Freitag FG, Lyss H, Nissan GR. Migraine disability, healthcare utilization, and expenditures following treatment in a tertiary headache center. Proc (Bayl Univ Med Cent). 2013;26(4):363–7.

    Article  Google Scholar 

  77. Lake AE III, Saper JR, Hamel RL. Comprehensive inpatient treatment of refractory chronic daily headache. Headache. 2009;49(4):555–62.

    Article  PubMed  Google Scholar 

  78. Drucker P, Tepper S. Daily sumatriptan for detoxification from rebound. Headache. 1998;38:687–90.

    Article  CAS  PubMed  Google Scholar 

  79. Hagen K, Albretsen C, Vilming ST, Salvesen R, Gronning M, Helde G, et al. Management of medication overuse headache: 1-year randomized multicentre open-label trial. Cephalalgia. 2009;29(2):221–32.

    Article  CAS  PubMed  Google Scholar 

  80. Zeeberg P, Olesen J, Jensen R. Probable medication-overuse headache: the effect of a 2-month drug-free period. Neurology. 2006;66(12):1894–8.

    Article  PubMed  Google Scholar 

  81. Raggi A, Giovannetti AM, Leonardi M, Sansone E, Schiavolin S, Curone M, et al. Predictors of 12-months relapse after withdrawal treatment in hospitalized patients with chronic migraine associated with medication overuse: a longitudinal observational study. Headache. 2017;57(1):60–70.

    Article  PubMed  Google Scholar 

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Disclosures

H. C. Diener received honoraria for his participation in clinical trials, contribution to advisory boards, or oral presentations from Addex Pharma, Alder, Allergan, Almirall, Amgen, Autonomic Technology, AstraZeneca, Bayer Vital, Berlin Chemie, Böhringer Ingelheim, Bristol-Myers Squibb, Chordate, Coherex, CoLucid, Electrocore, GlaxoSmithKline, Grünenthal, Janssen-Cilag, Labrys Biologics, Lilly, La Roche, 3 M Medica, Medtronic, Menerini, Minster, MSD, Neuroscore, Novartis, Johnson & Johnson, Pierre Fabre, Pfizer, Schaper and Brümmer, Sanofi, St. Jude, Teva, and Weber & Weber. Financial support for research projects was provided by Allergan, Almirall, AstraZeneca, Bayer, Electrocore, GSK, Janssen-Cilag, MSD and Pfizer. Headache research at the Department of Neurology in Essen is supported by the German Research Council (DFG), the German Ministry of Education and Research (BMBF), and the European Union. H.C. Diener has no ownership interest and does not own stocks of any pharmaceutical company. HCD serves on the editorial boards of Cephalalgia and Lancet Neurology. HCD chairs the Clinical Guidelines Committee of the German Society of Neurology.

D. Holle-Lee has received financial support for research projects from Allergan, Grünenthal, and Lilly and research support from EFIC.

F. Freitag is an advisor to the Migraine Research Foundation and BioHealthonomics. He has received financial support for clinical research, consulting, and educational presentations from Alder, Allergan, Amgen, Avanir, Depomed, Mayo Clinic Phoenix, Dr. Reddy, Teva, and Weber & Weber.

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Diener, HC., Holle-Lee, D., Freitag, F.G. (2019). Medication Overuse in Chronic Daily Headache. In: Green, M., Cowan, R., Freitag, F. (eds) Chronic Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-91491-6_14

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