Abstract
Aerobic exercise produces changes in cerebral oxyhaemoglobin (O2Hb) concentration; however, the effects of exercise on O2Hb during the post-exercise period remain to be established. The aim of the present study was to evaluate O2Hb levels during and after a 20-min bout of moderate-intensity cycling exercise. After a 3-min rest period, 12 healthy volunteers (9 women, 3 men) cycled for 20 min at an intensity corresponding to 50% of their VO2max, after which they were monitored during a 15-min post-exercise rest period. O2Hb levels in the right (R-PFC) and left prefrontal cortices (L-PFC), right (R-PMA) and left premotor areas (L-PMA), supplementary motor area (SMA), and primary motor cortex (M1) were measured using near-infrared spectroscopy. A one-way repeated-measures analysis of variance (ANOVA) was performed to compare mean pre-exercise O2Hb levels with O2Hb levels during the last 5 min of exercise and the last 5 min of the post-exercise rest period. O2Hb levels increased significantly (p < 0.01) between the pre-exercise rest period and the last 5 min of the exercise session for each region of interest (range: 0.040–0.085 mM·cm). O2Hb levels did not return to pre-exercise values during the 15-min post-exercise rest period. O2Hb levels during the last 5 min of the post-exercise rest period were significantly higher than pre-exercise values in the L-PFC, L-PMA, SMA, and M1 (p < 0.01). Our results indicate that cortical oxygenation persists for at least 15 min following a 20-min bout of moderate-intensity cycling, and that aerobic exercise may facilitate neuroplasticity.
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Raichlen DA, Alexander GE (2017) Adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health. Trends Neurosci 40(7):408–421. https://doi.org/10.1016/j.tins.2017.05.001
Hillman CH, Erickson KI, Kramer AF (2008) Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 9(1):58–65. https://doi.org/10.1038/nrn2298
Anazodo UC, Shoemaker JK, Suskin N et al (2013) An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation. Neuro Image Clin 3:388–395. https://doi.org/10.1016/j.nicl.2013.09.011
Endo K, Matsukawa K, Liang N et al (2013) Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation. J Physiol Sci 63(4):287–298. https://doi.org/10.1007/s12576-013-0267-6
Yanagisawa H, Dan I, Tsuzuki D et al (2010) Acute moderate exercise elicits increased dorsolateral prefrontal activation and improves cognitive performance with Stroop test. NeuroImage 50(4):1702–1710. https://doi.org/10.1016/j.neuroimage.2009.12.023
Hyodo K, Dan I, Suwabe K et al (2012) Acute moderate exercise enhances compensatory brain activation in older adults. Neurobiol Aging 33(11):2621–2632. https://doi.org/10.1016/j.neurobiolaging.2011.12.022
Hiura M, Nariai T, Ishii K et al (2014) Changes in cerebral blood flow during steady-state cycling exercise: a study using oxygen-15-labeled water with PET. J Cereb Blood Flow Metab 34(3):389–396. https://doi.org/10.1038/jcbfm.2013.220
American Thoracic S, American College of Chest P (2003) ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 167(2):211–277. https://doi.org/10.1164/rccm.167.2.211
Rupp T, Perrey S (2008) Prefrontal cortex oxygenation and neuromuscular responses to exhaustive exercise. Eur J Appl Physiol 102(2):153–163. https://doi.org/10.1007/s00421-007-0568-7
Boas DA, Gaudette T, Strangman G et al (2001) The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics. NeuroImage 13(1):76–90. https://doi.org/10.1006/nimg.2000.0674
Tamura M, Hoshi Y, Okada F (1997) Localized near-infrared spectroscopy and functional optical imaging of brain activity. Philos Trans R Soc Lond Ser B Biol Sci 352(1354):737–742. https://doi.org/10.1098/rstb.1997.0056
Miyai I, Tanabe HC, Sase I et al (2001) Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. NeuroImage 14(5):1186–1192. https://doi.org/10.1006/nimg.2001.0905
Obrig H, Wolf T, Doge C et al (1996) Cerebral oxygenation changes during motor and somatosensory stimulation in humans, as measured by near-infrared spectroscopy. Adv Exp Med Biol 388:219–224
Shibuya K, Kuboyama N, Tanaka J (2014) Changes in ipsilateral motor cortex activity during a unilateral isometric finger task are dependent on the muscle contraction force. Physiol Meas 35(3):417–428. https://doi.org/10.1088/0967-3334/35/3/417
Takahashi T, Takikawa Y, Kawagoe R et al (2011) Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task. NeuroImage 57(3):991–1002. https://doi.org/10.1016/j.neuroimage.2011.05.012
Miyazawa T, Horiuchi M, Komine H et al (2013) Skin blood flow influences cerebral oxygenation measured by near-infrared spectroscopy during dynamic exercise. Eur J Appl Physiol 113(11):2841–2848. https://doi.org/10.1007/s00421-013-2723-7
Tsubaki A, Takehara N, Sato D et al (2017) Cortical oxyhemoglobin elevation persists after moderate-intensity cycling exercise: a near-infrared spectroscopy study. Adv Exp Med Biol 977:261–268. https://doi.org/10.1007/978-3-319-55231-6_36
Frangos JA, Eskin SG, McIntire LV et al (1985) Flow effects on prostacyclin production by cultured human endothelial cells. Science 227(4693):1477–1479
Dimmeler S, Fleming I, Fisslthaler B et al (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399(6736):601–605. https://doi.org/10.1038/21224
Dietrich A (2006) Transient hypofrontality as a mechanism for the psychological effects of exercise. Psychiatry Res 145(1):79–83. https://doi.org/10.1016/j.psychres.2005.07.033
Niederhauser BD, Rosenbaum BP, Gore JC et al (2008) A functional near-infrared spectroscopy study to detect activation of somatosensory cortex by peripheral nerve stimulation. Neurocrit Care 9(1):31–36. https://doi.org/10.1007/s12028-007-9022-2
Bhambhani Y, Malik R, Mookerjee S (2007) Cerebral oxygenation declines at exercise intensities above the respiratory compensation threshold. Respir Physiol Neurobiol 156(2):196–202. https://doi.org/10.1016/j.resp.2006.08.009
Acknowledgments
This study was supported by a Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (15K01433) and a Grant-in-Aid for Exploratory Research from the Niigata University of Health and Welfare (H28C15).
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Tsubaki, A. et al. (2018). Changes in Cerebral Oxyhaemoglobin Levels During and After a Single 20-Minute Bout of Moderate-Intensity Cycling. In: Thews, O., LaManna, J., Harrison, D. (eds) Oxygen Transport to Tissue XL. Advances in Experimental Medicine and Biology, vol 1072. Springer, Cham. https://doi.org/10.1007/978-3-319-91287-5_20
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