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I Can “See” Clearly Now

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Immunohematology and Transfusion Medicine

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Abstract

A 16-year-old woman with sickle cell disease now presents with aplastic crisis with a hematocrit (Hct) of 17% (the patient’s baseline Hct is 28%). The patient has been transfused many times with the last red blood cell (RBC) transfusion occurring 1 month ago. The patient has a known history of anti-E antibody. A sample (ethylenediaminetetraacetic acid [EDTA] anticoagulant) is submitted to the blood bank for stat type and screen with request for two RBC units.

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References

  1. Shirey RS, Edwards RE, Ness PM. The risk of alloimmunization to c (Rh4) in R1R1 patients who present with an anti-E. Transfusion. 1994;34:756–8.

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Recommended Reading

  • Klein HG, Anstee DJ. The Rh blood group system (including LW and RHAG). In: Klein HG, Anstee DJ, editors. Mollison’s blood transfusion in clinical medicine. 12th ed. West Sussex: Wiley; 2014. p. 197.

    Chapter  Google Scholar 

  • Leger RM. The positive direct antiglobulin test and immune-mediated hemolysis. In: Fung MK, Grossman BJ, Hillyer CD, Westhoff CM, editors. Technical manual. 18th ed. Bethesda: AABB; 2014. p. 425.

    Google Scholar 

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Authors and Affiliations

  1. Icahn School of Medicine, Mount Sinai Health System, New York, NY, USA

    Mark T. Friedman & Jeffrey S. Jhang

  2. Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA

    Kamille A. West

  3. Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Peyman Bizargity

  4. Department of Pathology, Children’s Hospital Colorado, Aurora, CO, USA

    Kyle Annen

Authors
  1. Mark T. Friedman
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  2. Kamille A. West
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  3. Peyman Bizargity
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  4. Kyle Annen
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  5. Jeffrey S. Jhang
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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Jhang, J.S. (2018). I Can “See” Clearly Now. In: Immunohematology and Transfusion Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-90960-8_6

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  • DOI: https://doi.org/10.1007/978-3-319-90960-8_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90959-2

  • Online ISBN: 978-3-319-90960-8

  • eBook Packages: MedicineMedicine (R0)

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