Abstract
Chronic lung allograft dysfunction (CLAD, an umbrella term which encompasses two subtypes—restrictive allograft syndrome (RAS) and bronchiolitis obliterans syndrome (BOS)) remains the major barrier to long-term survival after lung transplantation. CLAD affects approximately 10% of patients each year and has proven a particularly difficult problem to address, with no major improvements in survival for 3 decades. In this chapter, current diagnostic and management paradigms are discussed, as are preventative approaches. Finally, a more optimistic outlook for patients developing CLAD in coming years, based on a better understanding of pathogenesis, is outlined.
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Chambers, D.C. (2019). Chronic Lung Allograft Dysfunction: Phenotypes and the Future. In: Glanville, A. (eds) Essentials in Lung Transplantation . Springer, Cham. https://doi.org/10.1007/978-3-319-90933-2_11
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DOI: https://doi.org/10.1007/978-3-319-90933-2_11
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