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Stem Cell Applications in Spinal Cord Injury: A Primer

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Stem Cell Genetics for Biomedical Research

Abstract

Despite advances in perioperative care, spinal cord injury (SCI) continues to be a devastating neurological condition. As SCI pathophysiology is multifaceted and time-dependent, the adaptive nature of cell therapy has been considered a promising approach for addressing these issues. In this chapter, we review the primary therapeutic targets of stem cell therapy including neuroprotection and neuroregeneration. Further, we present an in-depth review of the primary stem cell candidates (neural stem/progenitor and mesenchymal stem cells), a brief discussion of other cell types, and the status of combinatorial therapies for SCI. In closing, we discuss the translational challenges at the frontier and the progress made at the trial stage.

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Authors and Affiliations

  1. University of Toronto & Krembil Research Institute, Toronto, ON, Canada

    James Hong & Christopher E. Rodgers

  2. University of Toronto, Toronto, ON, Canada

    Michael G. Fehlings

  3. University Health Network, Toronto, ON, Canada

    Michael G. Fehlings

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  1. James Hong
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  1. Duran i Reynals Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Raul Delgado-Morales

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Hong, J., Rodgers, C.E., Fehlings, M.G. (2018). Stem Cell Applications in Spinal Cord Injury: A Primer. In: Delgado-Morales, R. (eds) Stem Cell Genetics for Biomedical Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90695-9_4

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