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Microbiome and Gut Immunity: T Cells

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Book cover The Gut Microbiome in Health and Disease

Abstract

The gastrointestinal tract is colonized with a huge number of microbes, which are instrumental for the development, homeostasis, and fine-tuning of the immune system. Recent evidence suggests that microbiota very efficiently modulates conventional and regulatory T cell responses that are required for effective host defense against invading pathogens and avoidance of autoimmunity and other immunopathologic conditions, respectively. In this review, we discuss the interplay between the microbiota and T cells, with a particular focus on the de novo induction of regulatory T cells within gut-draining lymph nodes (LNs), the impact of microbiota-derived metabolites on T cell differentiation, and the functional role of unique regulatory T cell subsets within the intestinal immune system.

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Authors and Affiliations

  1. Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

    Joern Pezoldt, Juhao Yang, Mangge Zou & Jochen Huehn

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  1. Joern Pezoldt
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  2. Juhao Yang
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  3. Mangge Zou
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  4. Jochen Huehn
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Correspondence to Jochen Huehn .

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  1. Chair of Nutrition and Immunology, Technical University Munich, Freising, Germany

    Dirk Haller

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Pezoldt, J., Yang, J., Zou, M., Huehn, J. (2018). Microbiome and Gut Immunity: T Cells. In: Haller, D. (eds) The Gut Microbiome in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-90545-7_9

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