Abstract
A critical appraisal of the role of FDG PET in Pyrexia of Unknown Origin (PUO) depends on an understanding of current concepts of PUO and systematic review of available evidence. This chapter provides an introduction to case definitions of PUO and summarises the current evidence, reviews available guidelines and discusses limitations in the application of FDG PET/CT for investigation of PUO.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore). 1961;40:1–30.
Knockaert DC, Vanderschueren S, Blockmans D. An evidence-based approach to fever of unknown origin. Arch Intern Med. 2003;163(16):1976–7.
Bleeker-Rovers CP, Vos FJ, de Kleijn EM, Mudde AH, Dofferhoff TS, Richter C, et al. A prospective multicenter study on fever of unknown origin: the yield of a structured diagnostic protocol. Medicine. 2007;86(1):26–38.
Bharucha T, Cockbain B, Brown M. Pyrexia of unknown origin: revisiting concepts to reflect on current clinical practice. Br J Hosp Med. 2016;77:579–83.
Mourad O, Palda V, Detsky AS. A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med. 2003;163(5):545–51.
Gaeta GB, Fusco FM, Nardiello S. Fever of unknown origin: a systematic review of the literature for 1995-2004. Nucl Med Commun. 2006;27(3):205–11.
Naito T, Mitsumoto F, Morita H, Mizooka M, Oono S, Ukimura A, et al. A multi-institution retrospective study on causative diseases and diagnostic methods for fevers of unknown origin in Japan: A project of the japanese society of general hospital medicine. J Gen Intern Med. 2013;28:S10.
Vaidyanathan S, Patel CN, Scarsbrook AF, Chowdhury FU. FDG PET/CT in infection and inflammation–current and emerging clinical applications. Clin Radiol. 2015;70(7):787–800.
Bharucha T, Rutherford A, Skeoch S, Alavi A, Brown M, Galloway J. Diagnostic yield of FDG-PET/CT in fever of unknown origin: a systematic review, meta-analysis and Delphi exercise. Clin Radiol. 2017;72:764–71.
Boellaard R, Delgado-Bolton R, Oyen WJG, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328–54.
Buscombe J. Guidelines for the use of F-18-FDG in infection and inflammation: a new step in cooperation between the EANM and SNMMI. Eur J Nucl Med Mol Imaging. 2013;40(7):1120–1.
RCP/RCR/BSNM. Evidence-based indications for the use of PET-CT in the UK 2013; 2013.
Dibble EH, Yoo DC, Noto RB. Role of PET/CT in workup of fever without a source. Radiographics. 2016;36(4):1166–77.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Bharucha, T., Wagner, T., Pencharz, D. (2018). The Role of FDG PET/CT in the Investigation of Pyrexia of Unknown Origin. In: Wagner, T., Basu, S. (eds) PET/CT in Infection and Inflammation . Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-90412-2_1
Download citation
DOI: https://doi.org/10.1007/978-3-319-90412-2_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-90411-5
Online ISBN: 978-3-319-90412-2
eBook Packages: MedicineMedicine (R0)