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The Role of FDG PET/CT in the Investigation of Pyrexia of Unknown Origin

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PET/CT in Infection and Inflammation

Abstract

A critical appraisal of the role of FDG PET in Pyrexia of Unknown Origin (PUO) depends on an understanding of current concepts of PUO and systematic review of available evidence. This chapter provides an introduction to case definitions of PUO and summarises the current evidence, reviews available guidelines and discusses limitations in the application of FDG PET/CT for investigation of PUO.

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References

  1. Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore). 1961;40:1–30.

    Article  CAS  Google Scholar 

  2. Knockaert DC, Vanderschueren S, Blockmans D. An evidence-based approach to fever of unknown origin. Arch Intern Med. 2003;163(16):1976–7.

    Article  PubMed  Google Scholar 

  3. Bleeker-Rovers CP, Vos FJ, de Kleijn EM, Mudde AH, Dofferhoff TS, Richter C, et al. A prospective multicenter study on fever of unknown origin: the yield of a structured diagnostic protocol. Medicine. 2007;86(1):26–38.

    Article  PubMed  Google Scholar 

  4. Bharucha T, Cockbain B, Brown M. Pyrexia of unknown origin: revisiting concepts to reflect on current clinical practice. Br J Hosp Med. 2016;77:579–83.

    Article  Google Scholar 

  5. Mourad O, Palda V, Detsky AS. A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med. 2003;163(5):545–51.

    Article  PubMed  Google Scholar 

  6. Gaeta GB, Fusco FM, Nardiello S. Fever of unknown origin: a systematic review of the literature for 1995-2004. Nucl Med Commun. 2006;27(3):205–11.

    Article  PubMed  Google Scholar 

  7. Naito T, Mitsumoto F, Morita H, Mizooka M, Oono S, Ukimura A, et al. A multi-institution retrospective study on causative diseases and diagnostic methods for fevers of unknown origin in Japan: A project of the japanese society of general hospital medicine. J Gen Intern Med. 2013;28:S10.

    Google Scholar 

  8. Vaidyanathan S, Patel CN, Scarsbrook AF, Chowdhury FU. FDG PET/CT in infection and inflammation–current and emerging clinical applications. Clin Radiol. 2015;70(7):787–800.

    Article  CAS  PubMed  Google Scholar 

  9. Bharucha T, Rutherford A, Skeoch S, Alavi A, Brown M, Galloway J. Diagnostic yield of FDG-PET/CT in fever of unknown origin: a systematic review, meta-analysis and Delphi exercise. Clin Radiol. 2017;72:764–71.

    Article  CAS  PubMed  Google Scholar 

  10. Boellaard R, Delgado-Bolton R, Oyen WJG, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328–54.

    Article  CAS  PubMed  Google Scholar 

  11. Buscombe J. Guidelines for the use of F-18-FDG in infection and inflammation: a new step in cooperation between the EANM and SNMMI. Eur J Nucl Med Mol Imaging. 2013;40(7):1120–1.

    Article  CAS  PubMed  Google Scholar 

  12. RCP/RCR/BSNM. Evidence-based indications for the use of PET-CT in the UK 2013; 2013.

    Google Scholar 

  13. Dibble EH, Yoo DC, Noto RB. Role of PET/CT in workup of fever without a source. Radiographics. 2016;36(4):1166–77.

    Article  PubMed  Google Scholar 

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Correspondence to Thomas Wagner .

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Bharucha, T., Wagner, T., Pencharz, D. (2018). The Role of FDG PET/CT in the Investigation of Pyrexia of Unknown Origin. In: Wagner, T., Basu, S. (eds) PET/CT in Infection and Inflammation . Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-90412-2_1

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  • DOI: https://doi.org/10.1007/978-3-319-90412-2_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90411-5

  • Online ISBN: 978-3-319-90412-2

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