Esophageal Tumors

  • Konstantinos Konstantinidis
  • Kostas Papagiannopoulos
Part of the Current Clinical Pathology book series (CCPATH)


Esophageal tumors include a spectrum of benign and malignant disease which have been an integral part of a general thoracic surgeon practice. Esophageal cancer has grown in the last decade, and its management mandates a multidisciplinary approach from endoscopists, radiologists, oncologists, and surgeons. Benign esophageal tumors are often found incidentally, and their terminology depends on the layer that they originate from. Several surgical techniques apply to management of esophageal tumors which requires particular experience and often coordination with other surgical specialties. Minimally invasive approaches are also well documented but less applied to everyday practice.


Esophageal cancer Esophagectomy Leiomyoma Foregut cyst 


  1. 1.
    Gray SW, Rowe JS, Skandalakis JE. Surgical anatomy of the gastroesophageal junction. Am Surg. 1979;45(9):575–87.PubMedGoogle Scholar
  2. 2.
    Hamilton WJ. Human embryology. 4th ed. Baltimore: Williams & Wilkins; 1972.CrossRefGoogle Scholar
  3. 3.
    Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.CrossRefGoogle Scholar
  4. 4.
    Freedman ND, Abnet CC, Leitzmann MF, et al. A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol. 2007;165:1424–33.CrossRefGoogle Scholar
  5. 5.
    Lagergren J, Bergstrom R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340:825–31.CrossRefGoogle Scholar
  6. 6.
    NCCN Clinical Practice Guidelines in Oncology. Esophageal and esophagogastric junction cancers. Version 2.2017–7 Aug 2017.Google Scholar
  7. 7.
    Puli SR, Reddy JBK, Bechtold ML, Antillon D, Ibdah JA, Antillon MR. Staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-analysis and systematic review. World J Gastroenterol. 2008;14(10):1479–90.CrossRefGoogle Scholar
  8. 8.
    Altorki NK, Lee PC, Liss Y, et al. Multifocal neoplasia and nodal metastases in T1 esophageal carcinoma: implications for endoscopic treatment. Ann Surg. 2008;247:434–9.CrossRefGoogle Scholar
  9. 9.
    Bonavina L, Incarbone R, Lattuada E, et al. Preoperative laparoscopy in management of patients with carcinoma of the esophagus and of the esophagogastric junction. J Surg Oncol. 1997;65(3):171–4.CrossRefGoogle Scholar
  10. 10.
    Sugarbaker DJ, Jaklitsch MT, Liptay MJ. Thoracoscopic staging and surgical therapy for esophageal cancer. Chest. 1995;107(6 Suppl):218S–23S.CrossRefGoogle Scholar
  11. 11.
    Veronesi G, Cerfolio R, Cingolani R, Rueckert JC, Soler L, Toker A, Cariboni U, Bottoni E, Fumagalli U, Mel F, Milli C, Novellis P, Voulaz E, Alloisio M. Report on first international workshop on robotic surgery in thoracic oncology. Front Oncol. 2016;6:214.CrossRefGoogle Scholar
  12. 12.
    Eizaguirre E, Larburu S, Asensio JI, Rodriguez A, Elorza JL, Loyola F, Urdapilleta G, Navascués JME. Treatment of anastomotic leaks with metallic stent after esophagectomies. Dis Esophagus. 2016;29:86–92.CrossRefGoogle Scholar
  13. 13.
    Hulscher JBF, van Sandick JW, de Boer AGEM, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med. 2002;347(21):1662–9.CrossRefGoogle Scholar
  14. 14.
    Choong CK, Meyers BF. Benign esophageal tumors: introduction, incidence, classification, and clinical features. Semin Thorac Cardiovasc Surg. 2003;15:3–8.CrossRefGoogle Scholar
  15. 15.
    Odze R, Antonioli D, Shocket D, et al. Esophageal squamous papillomas: a clinicopathologic study of 38 lesions and analysis for human papillomavirus by polymerase chain reaction. Am J Surg Pathol. 1993;19(8):803–12.CrossRefGoogle Scholar
  16. 16.
    Tsai S-J, Lin C-C, Chang C-W, Hung C-Y, Shieh T-Y, Wang H-Y, Shih S-C, Chen M-J. Benign esophageal lesions: endoscopic and pathologic features. World J Gastroenterol. 2015;21(4):1091–8.CrossRefGoogle Scholar
  17. 17.
    Watanabe T, Miyazaki T, Saito H, Yoshida T, Kumakura Y, Honjyo H, Yokobori T, Sakai M, Sohda M, Kuwano H. Resection of an esophageal schwannoma with thoracoscopic surgery: a case report. Surg Case Rep. 2016;2:127.CrossRefGoogle Scholar
  18. 18.
    Mutrie CJ, Donahue DM, Wain JC, et al. Esophageal leiomyoma: a 40-year experience. Ann Thorac Surg. 2005;79:1122–5.CrossRefGoogle Scholar
  19. 19.
    Palanivelu C, Rangarajan M, Senthilkumar R, Annapoorni S, Jategaonkar PA. Thoracoscopic management of benign tumors of the mid-esophagus: a retrospective study. Int J Surg. 2007;5:328–31.CrossRefGoogle Scholar
  20. 20.
    De Giacomo T, Bruschini P, Arcieri S, Ruberto F, Venuta F, Diso D, Francioni F. Partial oesophagectomy for giant leiomyoma of the oesophagus: report of 7 cases. Eur J Cardiothorac Surg. 2015;47:143–5.CrossRefGoogle Scholar
  21. 21.
    Kuwano H, Sadanaga N, Watanabe M, Yasuda M, Nozoe T, Sugimachi K. Esophageal squamous cell carcinoma occurring in the surface epithelium over a benign tumor. J Surg Oncol. 1995;59:268–72.CrossRefGoogle Scholar
  22. 22.
    Rahili A, D’Amata G, Avallone S, Piche M, Benchimol D. Concomitant leiomyoma and leiomyosarcoma of the oesophagus. J Exp Clin Cancer Res. 2005;24:487–91.PubMedGoogle Scholar
  23. 23.
    Nakao A, Urushihara N, Yagi T, Choda Y, Hamada M, Kataoka K, et al. Rapidly enlarging esophageal duplication cyst. J Gastroenterol. 1999;34:246–9.CrossRefGoogle Scholar
  24. 24.
    Sonthaliaa N, Jaina SS, Surudea RG, Mohitea AR, Rathi PM. Congenital esophageal duplication cyst: a rare cause of dysphagia in an adult. Gastroenterol Res. 2016;9(4–5):79–82.CrossRefGoogle Scholar
  25. 25.
    Neo EL, Watson DI, Bessell JR. Acute ruptured esophageal duplication cyst. Dis Esophagus. 2004;17:109–11.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Konstantinos Konstantinidis
    • 1
  • Kostas Papagiannopoulos
    • 1
  1. 1.St. James University HospitalLeedsUK

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