Tandem Therapies in Extracorporeal Support

  • Rachel Sirignano
  • Meral Patel
  • Matthew L. PadenEmail author


Continuous renal replacement therapy (CRRT) has traditionally been used in patients with single organ failure who are hemodynamically unstable enough to tolerate intermittent hemodialysis. However, as technology advances and patient populations become more complex, there are an increasing number of patients with multi-organ failure who require multiple methods of extracorporeal organ support. While theoretical contraindications exist with each established extracorporeal device, additional circuits may be connected in tandem to each other to provide simultaneous extracorporeal organ support. In this chapter, we will discuss the use of multiple extracorporeal therapies, such as extracorporeal membrane oxygenation (ECMO) for cardiac and pulmonary failures, the use of apheresis procedures for liver failure support, in conjunction with CRRT for renal support to provide a total platform of extracorporeal life support (ECLS).


Extracorporeal membrane oxygenation Tandem Apheresis Plasma exchange Extracorporeal life support 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rachel Sirignano
    • 1
  • Meral Patel
    • 1
  • Matthew L. Paden
    • 1
    Email author
  1. 1.Division of Pediatric Critical CareEmory UniversityAtlantaUSA

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