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Programmed Cell Death in CIRI

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Book cover Cerebral Ischemic Reperfusion Injuries (CIRI)

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Neurons in the ischemic penumbra or peri-infarct zone may undergo delayed cell death which called programmed cell death (PCD) and thus they are potentially recoverable for some time after the onset of stroke. There were three major morphologies of PCD in the cerebral ischemic injury, including apoptosis, autophagy and programmed necrosis (also known as necroptosis). In this review we will discuss the characteristics, molecular mechanism of each PCD mode and their role in cerebral ischemia and reperfusion injury (CIRI), furthermore crosstalk between various modes of PCD is also dicussed.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Ruili Wei, Yang Xu, Jie Zhang & Benyan Luo

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  1. Ruili Wei
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  2. Yang Xu
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  3. Jie Zhang
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  4. Benyan Luo
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Correspondence to Benyan Luo .

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Editors and Affiliations

  1. Department of Vascular Neurosurgery, PLA Rocket Force General Hospital, Beijing, China

    Weijian Jiang

  2. Department of Neurology, University of California Irvine, Irvine, California, USA

    Wengui Yu

  3. Department of Neurosurgery, Tangdu Hospital of Air Force Medical University, Xi’an, China

    Yan Qu

  4. Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Zhongsong Shi

  5. Department of Neurology, The First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Benyan Luo

  6. Department of Anesthesiology, Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Wei, R., Xu, Y., Zhang, J., Luo, B. (2018). Programmed Cell Death in CIRI. In: Jiang, W., Yu, W., Qu, Y., Shi, Z., Luo, B., Zhang, J. (eds) Cerebral Ischemic Reperfusion Injuries (CIRI). Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90194-7_5

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