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Animal Models of REM Sleep Behavior Disorder

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Rapid-Eye-Movement Sleep Behavior Disorder

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Abstract

Evidence from animal studies indicates the importance of the dorsomedial and medial pontine tegmentum and the ventromedial medulla in maintaining muscle tone inhibition during REM sleep; however, the symptoms in animals with lesions in these areas do not fully mimic the symptoms of human REM sleep behavior disorder (RBD). This chapter summarizes the findings in our laboratory and offers a hypothesis on the neural network involved in the modulation of motor activity in sleep, the neural structures participating in the generation of RBD, and a hypothetical link between RBD and Parkinsonism.

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Author information

Authors and Affiliations

  1. Department of Psychiatry and Biobehavior Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Yuan-Yang Lai & Jerome M. Siegel

  2. Department of Veterans Affairs, VA Greater Los Angeles HealthCare System, Sepulveda, North Hills, CA, USA

    Yuan-Yang Lai, Kung-Chiao Hsieh & Jerome M. Siegel

Authors
  1. Yuan-Yang Lai
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  2. Kung-Chiao Hsieh
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  3. Jerome M. Siegel
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Corresponding author

Correspondence to Yuan-Yang Lai .

Editor information

Editors and Affiliations

  1. Minnesota Regional Sleep Disorders Center, Departments of Psychiatry, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, MN, USA

    Carlos H. Schenck

  2. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria

    Birgit Högl

  3. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Aleksandar Videnovic

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Lai, YY., Hsieh, KC., Siegel, J.M. (2019). Animal Models of REM Sleep Behavior Disorder. In: Schenck, C., Högl, B., Videnovic, A. (eds) Rapid-Eye-Movement Sleep Behavior Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-90152-7_42

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  • DOI: https://doi.org/10.1007/978-3-319-90152-7_42

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-90152-7

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