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The Genetics and Development of Scoliosis pp 179–193Cite as

Adolescence and Scoliosis: Deciphering the Complex Biology of Puberty and Scoliosis

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Abstract

Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal disorder, affecting 2–5.2% of the population. Individuals with AIS have, for a long time, been known to exhibit differences in weight, height, body mass index (BMI), pubertal progression and levels of circulating hormones, suggesting that AIS may arise due to metabolism-endocrine-gene interactions. Here, we present an overview of biological changes that occur during puberty, in relation to the developing spine, along with the pathways involved, with an emphasis on those linked to AIS through recent human genetic studies.

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Authors and Affiliations

  1. Department of Anatomy, University of Otago, Dunedin, New Zealand

    Jeremy McCallum-Loudeac & Megan J. Wilson

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  1. Jeremy McCallum-Loudeac
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  1. School of Life Sciences, Arizona State University, Tempe, Arizona, USA

    Kenro Kusumi

  2. Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia

    Sally L. Dunwoodie

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McCallum-Loudeac, J., Wilson, M.J. (2018). Adolescence and Scoliosis: Deciphering the Complex Biology of Puberty and Scoliosis. In: Kusumi, K., Dunwoodie, S. (eds) The Genetics and Development of Scoliosis. Springer, Cham. https://doi.org/10.1007/978-3-319-90149-7_8

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