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Diagnostic Imaging for Thoracic Surgery pp 189–199Cite as

Staging of Malignant Pleural Mesothelioma

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Abstract

Primary malignancy of the pleura is rare and usually has a poor prognosis. Malignant pleural mesothelioma is linked to occupational and environmental exposures with a latency period of 2–6 decades. Patients usually present late in the course of the disease with chest pain, dyspnea, and weight loss. Outcomes are related to both the histological subtype of the tumor and staging at presentation. Computed tomography (CT) is the imaging modality most commonly used for preliminary noninvasive clinical staging. Magnetic resonance (MR) imaging, particularly dynamic sequences, is useful in evaluating chest wall, diaphragm, and mediastinal invasion. It can be helpful when CT findings are equivocal to distinguish resectable from unresectable disease. Positron-emission tomography (PET)/CT is performed in patients being considered for surgical resection, as it may identify nodal and/or distant metastases not seen on CT. PET/CT may also have a role in evaluation of response to treatment and detection of recurrent disease. The 8th edition of the TNM staging system is in effect as of January 1, 2018.

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References

  1. Mark EJ, Kradin RL. Pathological recognition of diffuse malignant mesothelioma of the pleura: the significance of the historical perspective as regards this signal tumor. Semin Diagn Pathol. 2006;23(1):25–34.

    Article  PubMed  Google Scholar 

  2. Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesotheliomas and asbestos exposure in Northwestern Cape Province. Br J Ind Med. 1960;17:260–71.

    PubMed  PubMed Central  CAS  Google Scholar 

  3. Newhouse ML, Thompson H. Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area. Br J Ind Med. 1965;22(4):261–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  4. IARC. Monographs on evaluation of carcinogenic risk to humans: World Health Organization Press; 2012. http://monographs.iarc.fr/ENG/Monographs/vol100C/index.php. Accessed 28 July 2017

    Google Scholar 

  5. Prazakova S, Thomas PS, Sandrini A, Yates DH. Asbestos and the lung in the 21st century: an update. Clin Respir J. 2014;8(1):1–10.

    Article  PubMed  Google Scholar 

  6. Carbone M, Baris YI, Bertino P, et al. Erionite exposure in North Dakota and Turkish villages with mesothelioma. Proc Natl Acad Sci U S A. 2011;108(33):13618–23.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Robinson BM. Malignant pleural mesothelioma: an epidemiological perspective. Ann Cardiothorac Surg. 2012;1(4):491–6.

    PubMed  PubMed Central  Google Scholar 

  8. World Health Organization. Asbestos: elimination of asbestos-related diseases: World Health Organization Media Centre; 2017. http://www.who.int/mediacentre/factsheets/fs343/en/. Accessed 06 Sept 2017

    Google Scholar 

  9. Schuz J, Schonfeld SJ, Kromhout H, et al. A retrospective cohort study of cancer mortality in employees of a Russian chrysotile asbestos mine and mills: study rationale and key features. Cancer Epidemiol. 2013;37(4):440–5.

    Article  CAS  PubMed  Google Scholar 

  10. Nickell LT Jr, Lichtenberger JP 3rd, Khorashadi L, Abbott GF, Carter BW. Multimodality imaging for characterization, classification, and staging of malignant pleural mesothelioma. Radiographics. 2014;34(6):1692–706.

    Article  PubMed  Google Scholar 

  11. Galateau-Salle F, Churg A, Roggli V, Travis WD. The 2015 World Health Organization classification of tumors of the Pleura: advances since the 2004 classification. J Thorac Oncol. 2016;11(2):142–54.

    Article  PubMed  Google Scholar 

  12. NCCN. Malignant pleural mesothelioma NCCN Evidence Blocks. NCCN.org: NCCN; 2017.

    Google Scholar 

  13. Agarwal PP, Seely JM, Matzinger FR, et al. Pleural mesothelioma: sensitivity and incidence of needle track seeding after image-guided biopsy versus surgical biopsy. Radiology. 2006;241(2):589–94.

    Article  PubMed  Google Scholar 

  14. Boutin C, Rey F, Viallat JR. Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma. A randomized trial of local radiotherapy. Chest. 1995;108(3):754–8.

    Article  CAS  PubMed  Google Scholar 

  15. West SD, Foord T, Davies RJ. Needle-track metastases and prophylactic radiotherapy for mesothelioma. Respir Med. 2006;100(6):1037–40.

    Article  PubMed  Google Scholar 

  16. Pass H, Giroux D, Kennedy C, et al. The IASLC Mesothelioma Staging Project: improving staging of a rare disease through international participation. J Thorac Oncol. 2016;11(12):2082–8.

    Article  PubMed  Google Scholar 

  17. Nowak AK, Chansky K, Rice DC, et al. The IASLC Mesothelioma Staging Project: Proposals for revisions of the T descriptors in the forthcoming eighth edition of the TNM Classification for Pleural Mesothelioma. J Thorac Oncol. 2016;11(12):2089–99.

    Article  PubMed  Google Scholar 

  18. Rusch VW, Chansky K, Kindler HL, et al. The IASLC Mesothelioma Staging Project: Proposals for the M Descriptors and for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Mesothelioma. J Thorac Oncol. 2016;11(12):2112–9.

    Article  PubMed  Google Scholar 

  19. Rice D, Chansky K, Nowak A, et al. The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma. J Thorac Oncol. 2016;11(12):2100–11.

    Article  PubMed  Google Scholar 

  20. Leung AN, Muller NL, Miller RR. CT in differential diagnosis of diffuse pleural disease. AJR Am J Roentgenol. 1990;154(3):487–92.

    Article  CAS  PubMed  Google Scholar 

  21. Wang ZJ, Reddy GP, Gotway MB, et al. Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics. 2004;24(1):105–19.

    Article  PubMed  Google Scholar 

  22. Sharma A, Fidias P, Hayman LA, Loomis SL, Taber KH, Aquino SL. Patterns of lymphadenopathy in thoracic malignancies. Radiographics. 2004;24(2):419–34.

    Article  PubMed  Google Scholar 

  23. Kim SB, Varkey B, Choi H. Diagnosis of malignant pleural mesothelioma by axillary lymph node biopsy. Chest. 1987;91(2):279–81.

    Article  CAS  PubMed  Google Scholar 

  24. Heelan RT, Rusch VW, Begg CB, Panicek DM, Caravelli JF, Eisen C. Staging of malignant pleural mesothelioma: comparison of CT and MR imaging. AJR Am J Roentgenol. 1999;172(4):1039–47.

    Article  CAS  PubMed  Google Scholar 

  25. Gill RR, Umeoka S, Mamata H, et al. Diffusion-weighted MRI of malignant pleural mesothelioma: prelimiary assessment of apparent diffusion coefficient in histologic subtypes. AJR Am J Roentgenol. 2010;19592:W125–30.

    Article  Google Scholar 

  26. Rusch VW. Extrapleural pneumonectomy and extended pleurectomy/decortication for malignant pleural mesothelioma: the Memorial Sloan-Kettering Cancer Center approach. Ann Cardiothorac Surg. 2012;1(4):523–31.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Patricia M. de Groot, Girish S. Shroff, Carol C. Wu & Brett W. Carter

  2. Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    David R. Rice

Authors
  1. Patricia M. de Groot
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  2. Girish S. Shroff
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  3. Carol C. Wu
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  4. David R. Rice
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  5. Brett W. Carter
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Corresponding author

Correspondence to Brett W. Carter .

Editor information

Editors and Affiliations

  1. Sapienza Università di Roma, Policlinico Umberto I, Rome, Italy

    Michele Anzidei

  2. Department of Thoracic Surgery, University of Rome Sapienza, Policlinico Umberto I, Rome, Italy

    Marco Anile

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de Groot, P.M., Shroff, G.S., Wu, C.C., Rice, D.R., Carter, B.W. (2018). Staging of Malignant Pleural Mesothelioma. In: Anzidei, M., Anile, M. (eds) Diagnostic Imaging for Thoracic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-89893-3_10

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  • DOI: https://doi.org/10.1007/978-3-319-89893-3_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-89892-6

  • Online ISBN: 978-3-319-89893-3

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