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The Role of Polymer Additives in Enhancing the Response of Calcium Phosphate Cement

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Orthopedic Biomaterials

Abstract

Bone defects caused by trauma, tumors, errors in development, disease, and fractures occur within young and aging populations. Dysfunction, impairment, and pain are the main reasons that patients seek clinical intervention each year. In many of these cases, revision procedures are needed due to subsequent bone infection and resorption, bone mass loss, reemergence of bone cancer reoccurrence or failure of new bone tissue to grow. Revision procedures and increased hospital stays can cost hundreds of thousands of dollars for a single patient, significant lost time from work, altered and restricted lifestyles, and in some cases, death. Additionally, high-risk individuals in the population have led to an increase in the need for additional surgical operations due to device or implant failure or infection. The dental and orthopedic device industry also face major consumer demands for more functional, bioinstructional, and longer-lasting implants. A significant body of research has been directed towards addressing these concerns by examining the use of polymer additives that enhance calcium phosphate cement properties through the addition of enhanced functionalities.

The number of papers, application and review papers, published on calcium phosphate cement is staggering as is the use of additives. This chapter’s mission is to provide a review of the most relevant developments in this field. The chapter’s focus is on the application of natural and synthetic polymers designed to enhance calcium phosphate cement (CPC) by enhancing CPC’s inherent properties and providing additional functionalities.

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Authors and Affiliations

  1. School of Biological Sciences and the Center for Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA

    David K. Mills

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Editors and Affiliations

  1. Department of Orthopedics School of Medicine, West Virginia University, Morgantown, West Virginia, USA

    Bingyun Li

  2. Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA

    Thomas Webster

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Mills, D.K. (2018). The Role of Polymer Additives in Enhancing the Response of Calcium Phosphate Cement. In: Li, B., Webster, T. (eds) Orthopedic Biomaterials . Springer, Cham. https://doi.org/10.1007/978-3-319-89542-0_14

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