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Notch and Neurogenesis

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Molecular Mechanisms of Notch Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1066))

Abstract

Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are tightly regulated by their local milieu or niche. In this chapter, we will discuss the role of Notch signaling in the control of neurogenesis and regeneration in the embryo and adult. Notch-dependence is a common feature among NSC populations, we will discuss how differences in Notch signaling might contribute to heterogeneity among adult NSCs. Understanding the fate of multiple NSC populations with distinct functions could be important for effective brain regeneration.

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Abbreviations

BMP:

Bone Morphogenic Protein

CNS:

Central Nervous System

DG:

Dentate Gyrus

Dll:

Delta-like

E:

Embryonic day

FGF:

Fibroblast Growth Factor

Hes:

Hairy and enhancer of split

IP:

Intermediate progenitor

IPC:

Intermediate progenitor cell

LV:

Lateral ventricle

NEPs:

Neuroepithelial Cells

NICD:

Notch intracellular domain

NSCs:

Neural Stem Cells

OB:

Olfactory Bulb

P:

Postnatal day

RA:

Retinoic Acid

RGC:

radial glia cell

RMS:

Rostral Migratory Stream

SGZ:

Subgranular Zone

Shh:

sonic hedgehog

SVZ:

Subventricular Zone

TAP:

transient amplifying progenitor

VZ:

Ventricular Zone

Wnt:

Wingless

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Acknowledgments

We thank the members of the Taylor lab for critical reading of the manuscript and for helpful discussions. This work was supported by the Swiss National Science Foundation (VT) and the SystemsX.ch, NeuroStemX project (VT) and the University of Basel (VT) and the Forschungsfond of the University of Basel (AE).

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Correspondence to Verdon Taylor .

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Engler, A., Zhang, R., Taylor, V. (2018). Notch and Neurogenesis. In: Borggrefe, T., Giaimo, B. (eds) Molecular Mechanisms of Notch Signaling. Advances in Experimental Medicine and Biology, vol 1066. Springer, Cham. https://doi.org/10.1007/978-3-319-89512-3_11

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