The Public Health Exposome

  • Paul D. JuarezEmail author


The exposome has been described by Wild as the measure of all of the exposures an individual has in a lifetime and how those exposures relate to health. The exposome represents the totality of exogenous (external) and endogenous (internal) exposures from conception onwards, simultaneously distinguishing, characterizing, and quantifying etiologic, mediating, moderating, and co-occurring risk and protective factors and their relationship to disease.

The exposome provides a systems science approach to bringing together and organizing data needed to model the relationships, mechanisms, and pathways among and between external exposures, endogenous exposures, health outcomes, and population-level health disparities. It holds promise for identifying completed exposure pathways from source of exposure in the natural, built, social, and policy environments to route of entry into the body, biomarkers of exposure, biomarkers of disease, disease phenotype, clinical outcomes, and population level disparities, across the lifespan, and between generations. This chapter proposes a new taxonomy for sequencing the public health exposome first described by Wild as the eco-exposome. The aim of this chapter is to identify a common taxonomy for conceptualizing and operationalizing environmental exposures as an important step towards articulating a science of health disparities.


Public health exposome Universal exposure-tracking framework 


  1. Adler NE, Boyce W, Chesney MA, Folkman S, Syme S (1993) Socioeconomic inequalities in health: no easy solution. JAMA 269(24):3140–3145. Scholar
  2. Adler NE, Boyce T, Chesney MA, Cohen S, Folkman S, Kahn RL, Syme SL (1994) Socioeconomic status and health: the challenge of the gradient. Am Psychol 49(1):15–24CrossRefGoogle Scholar
  3. Alicandro G, Rota M, Boffetta P, La Vecchia C (2016) Occupational exposure to polycyclic aromatic hydrocarbons and lymphatic and hematopoietic neoplasms: a systematic review and meta-analysis of cohort studies. Arch Toxicol 90(11):2643–2656. Scholar
  4. Allen EM, Alexander BH, MacLehose RF, Nelson HH, Ramachandran G, Mandel JH (2015) Cancer incidence among Minnesota taconite mining industry workers. Ann Epidemiol 25(11):811–815.e811. Scholar
  5. American Public Health Association (1950) The local health department: services and responsibilities. Am J Public Health Nations Health 40:67–72CrossRefGoogle Scholar
  6. Astrakianakis G, Seixas NS, Ray R, Camp JE, Gao DL, Feng Z, Li W, Wernli KJ, Fitzgibbons ED, Thomas DB, Checkoway H (2007) Lung cancer risk among female textile workers exposed to endotoxin. J Natl Cancer Inst 99(5):357–364. Scholar
  7. Atkinson RW, Mills IC, Walton HA, Anderson HR (2015) Fine particle components and health—a systematic review and meta-analysis of epidemiological time series studies of daily mortality and hospital admissions. J Expo Sci Environ Epidemiol 25(2):208–214. Scholar
  8. Atlanta Regional Health Forum, Atlanta Regional Commission (2006) Land use planning for public health: the role of local boards of health in community design and development. National Association of Local Boards of Health, Bowling Green, OHGoogle Scholar
  9. Balluz L, Wen XJ, Town M, Shire JD, Qualter J, Mokdad A (2007) Ischemic heart disease and ambient air pollution of particulate matter 2.5 in 51 counties in the U.S. Public Health Rep 122(5):626–633CrossRefGoogle Scholar
  10. Barraj LM, Tsuji JS, Scrafford CG (2007) The SHEDS-wood model: incorporation of observational data to estimate exposure to arsenic for children playing on CCA-treated wood structures. Environ Health Perspect 115(5):781–786. Scholar
  11. Barret M (1997) Initial tier screening of pesticides for groundwater concentration using the SCI-GROW model. USEPA, Washington, DCGoogle Scholar
  12. Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer PH, Nieuwenhuijsen MJ, Xun WW, Katsouyanni K, Dimakopoulou K, Marcon A, Vartiainen E, Lanki T, Yli-Tuomi T, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Östenson C-G, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Sørensen M, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita HB, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Jaensch A, Ineichen A, Tsai M-Y, Schaffner E, Probst-Hensch NM, Schindler C, Ragettli MS, Vilier A, Clavel-Chapelon F, Declercq C, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Vineis P, Brunekreef B (2015) Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the Multi-Center ESCAPE project. Environ Health Perspect 123(6):525–533. Scholar
  13. Blair AZT, Linos A, Stewart PA, Zhang YW, Cantor KP (2001) Occupation and leukemia: a population-based case-control study in Iowa and Minnesota. Am J Ind Med 40(1):3–14CrossRefGoogle Scholar
  14. Bodin M, Hartig T (2003) Does the outdoor environment matter for psychological restoration gained through running? Psychol Sport Exerc 4:141–153. Scholar
  15. Boers D, Zeegers M, Swaen G, Kant I, van den Brandt PA (2005) The influence of occupational exposure to pesticides, polycyclic aromatic hydrocarbons, diesel exhaust, metal dust, metal fumes, and mineral oil on prostate cancer: a prospective cohort study. Occup Environ Med 62(8):531–537. Scholar
  16. Bowler DE, Buyung-Ali LM, Knight TM, Pullin AS (2010) A systematic review of evidence for the added benefits to health of exposure to natural environments. BMC Public Health 10(1):456. Scholar
  17. Breitner S, Liu L, Cyrys J, Bruske I, Franck U, Schlink U, Leitte AM, Herbarth O, Wiedensohler A, Wehner B, Hu M, Pan XC, Wichmann HE, Peters A (2011) Sub-micrometer particulate air pollution and cardiovascular mortality in Beijing, China. Sci Total Environ 409:5196–5204. Scholar
  18. Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD (2010) Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American heart association. Circulation 121:2331–2378. Scholar
  19. Brown T, Young C, Rushton L, British Occupational Cancer Burden Study Group (2012) Occupational cancer in Britain: remaining cancer sites: brain, bone, soft tissue sarcoma and thyroid. Br J Cancer 107(Suppl 1):S85–S91. Scholar
  20. Brunekreef B (2013) Exposure science, the exposome, and public health. Environ Mol Mutagen 54:596–598. Scholar
  21. Buck Louis GM, Sundaram R (2012) Exposome: time for transformative research. Stat Med 31(22):2569–2575. Scholar
  22. Canadian Centre for Occupational Health and Safety (2017) Cancer sites associated with occupational exposures. Accessed 14 Mar 2017
  23. Cao J, Yang C, Li J, Chen R, Chen B, Gu D, Kan H (2011) Association between long-term exposure to outdoor air pollution and mortality in China: a cohort study. J Hazard Mater 186:1594–1600. Scholar
  24. Case BW, Abraham JL, Meeker G, Pooley FD, Pinkerton KE (2011) Applying definitions of “asbestos” to environmental and “low-dose” exposure levels and health effects, particularly malignant mesothelioma. J Toxicol Environ Health B Crit Rev 14(1–4):3–39. Scholar
  25. Centers for Disease Control and Prevention (2017) NCHHSTP social determinants of health. Accessed 14 Mar 2017
  26. Chen L, Mengersen K, Tong S (2007) Spatiotemporal relationship between particle air pollution and respiratory emergency hospital admissions in Brisbane, Australia. Sci Total Environ 373:57–67. Scholar
  27. Chuang C-S, Ho S-C, Lin C-L, Lin M-C, Kao C-H (2016) Risk of cerebrovascular events in pneumoconiosis patients: a population-based study, 1996–2011. Medicine 95(9):e2944. Scholar
  28. Cohen-Cline H, Turkheimer E, Duncan GE (2015) Access to green space, physical activity and mental health: a twin study. J Epidemiol Community Health 69(6):523CrossRefGoogle Scholar
  29. Cost Council on State Taxation (2015) Study: total state and local business taxes (fy15). Accessed 16 Mar 2017
  30. Coughlin SS, Smith SA (2015) The impact of the natural, social, built, and policy environments on breast cancer. J Environ Health Sci 1(3).
  31. Crimmins EM, Hayward MD, Seeman TE (2004) Race/ethnicity, socioeconomic status, and health. In: Anderson NB, Bulatao RA, Cohen B (eds) National Research Council (US) panel on race ethnicity, and health in later life. National Academies Press, Washington DCGoogle Scholar
  32. Crouse DL, Peters PA, van Donkelaar A, Goldberg MS, Villeneuve PJ, Brion O, Khan S, Atari DO, Jerrett M, Pope CA, Brauer M, Brook JR, Martin RV, Stieb D, Burnett RT (2012) Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study. Environ Health Perspect 120:708–714. Scholar
  33. Dadvand P, Nieuwenhuijsen MJ, Esnaola M, Forns J, Basagaña X, Alvarez-Pedrerol M, Rivas I, López-Vicente M, De Castro Pascual M, Su J, Jerrett M, Querol X, Sunyer J (2015) Green spaces and cognitive development in primary schoolchildren. Proc Natl Acad Sci 112(26):7937–7942. Scholar
  34. Dannemiller KC, Murphy JS, Dixon SL, Pennell KG, Suuberg EM, Jacobs DE, Sandel M (2013) Formaldehyde concentrations in household air of asthma patients determined using colorimetric detector tubes. Indoor Air 23(4):285–294. Scholar
  35. Dehbi H-M, Blangiardo M, Gulliver J, Fecht D, de Hoogh K, Al-Kanaani Z, Tillin T, Hardy R, Chaturvedi N, Hansell AL (2017) Air pollution and cardiovascular mortality with over 25 years follow-up: a combined analysis of two British cohorts. Environ Int 99:275–281. Scholar
  36. Dishaw L, Macaulay L, Roberts SC, Stapleton HM (2014) Exposures, mechanisms, and impacts of endocrine-active flame retardants. Curr Opin Pharmacol 19:125–133. Scholar
  37. Dong GH, Zhang P, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J (2012) Long-term exposure to ambient air pollution and respiratory disease mortality in Shenyang, China: a 12-year population-based retrospective cohort study. Respiration 84:360–368. Scholar
  38. Elwell Bostrom H, Shulaker B, Rippon J, Wood R (2017) Strategic and integrated planning for healthy, connected cities: Chattanooga case study. Prev Med 95(Suppl):S115–S119. Scholar
  39. Evans GW (2003) The built environment and mental health. J Urban Health 80(4):536–555. Scholar
  40. Fay JWJ, Ashford JR (1961) A survey of the methods developed in the national coal board’s pneumoconiosis field research for correlating environmental exposure with medical condition. Br J Ind Med 18(3):175–196Google Scholar
  41. GBD 2013 Risk Factors Collaborators, Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S et al (2015) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386(10010):2287–2323. Scholar
  42. Golden R (2011) Identifying an indoor air exposure limit for formaldehyde considering both irritation and cancer hazards. Crit Rev Toxicol 41(8):672–721. Scholar
  43. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci AM, Olsen A-K, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu C-W, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon E-Y, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams GP, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu H-Y, Park HH, Koturbash I, Miousse IR, Scovassi A, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D’Abronzo LS, Lin L-T, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez Guzman MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Leung PS, Nangia-Makker P, Cheng Q, Robey R, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Hamid RA, Langie SAS, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee T-J, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell W, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36(Suppl 1):S254–S296. Scholar
  44. Goswami E, Craven V, Dahlstrom DL, Alexander D, Mowat F (2013) Domestic asbestos exposure: a review of epidemiologic and exposure data. Int J Environ Res Public Health 10(11):5629–5670. Scholar
  45. GreenFacts Scientific Board (2017) Pesticides: occupational exposure and associated health effects. Accessed 14 Mar 2017
  46. Greiser EM, Greiser KH, Ahrens W, Hagen R, Lazszig R, Maier H, Schick B, Zenner HP (2012) Risk factors for nasal malignancies in German men: the South-German Nasal cancer study. BMC Cancer 12:506–506. Scholar
  47. Hamula C, Wang Z, Zhang H, Kwon E, Li X-F, Gabos S, Le XC (2006) Chromium on the hands of children after playing in playgrounds built from chromated copper arsenate (CCA)–treated wood. Environ Health Perspect 114(3):460–465. Scholar
  48. Hancock DG, Langley ME, Chia KL, Woodman RJ, Shanahan EM (2015) Wood dust exposure and lung cancer risk: a meta-analysis. Occup Environ Med 72(12):889–898. Scholar
  49. Handy DE, Castro R, Loscalzo J (2011) Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation 123(19):2145–2156. Scholar
  50. Hunter RF, Christian H, Veitch J, Astell-Burt T, Hipp JA, Schipperijn J (2015) The impact of interventions to promote physical activity in urban green space: a systematic review and recommendations for future research. Soc Sci Med 124:246–256. Scholar
  51. Hystad P, Davies HW, Frank L, Van Loon J, Gehring U, Tamburic L, Brauer M (2014) Residential greenness and birth outcomes: evaluating the influence of spatially correlated built-environment factors. Environ Health Perspect 122(10):1095–1102. Scholar
  52. Institute of Medicine (US) Committee on Assessing Interactions Among Social B, and Genetic Factors in Health (2006) Genes, behavior, and the social environment: moving beyond the nature/nurture debate. National Academies Press, Washington, DCGoogle Scholar
  53. International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431:931–945CrossRefGoogle Scholar
  54. Jones DP (2016) Sequencing the exposome: a call to action. Toxicol Rep 3:29–45. Scholar
  55. Juarez P (2013) Sequencing the public health genome. J Health Care Poor Underserved 24(1 Suppl):114–120. Scholar
  56. Juarez PD, Matthews-Juarez P, Hood DB, Im W, Levine RS, Kilbourne BJ, Langston MA, Al-Hamdan MZ, Crosson WL, Estes MG, Estes SM, Agboto VK, Robinson P, Wilson S, Lichtveld MY (2014) The public health exposome: a population-based, exposure science approach to health disparities research. Int J Environ Res Public Health 11(12):12866–12895. Scholar
  57. Kibble A, Harrison R (2005) Point sources of air pollution. Occup Med 55(6):425–431. Scholar
  58. Kim I, Ha J, Lee J-H, Yoo K-M, Rho J (2014) The relationship between the occupational exposure of trichloroethylene and kidney cancer. Ann Occup Environ Med 26:12–12. Scholar
  59. Kornartit C, Sokhi RS, Burton MA, Ravindra K (2010) Activity pattern and personal exposure to nitrogen dioxide in indoor and outdoor microenvironments. Environ Int 36(1):36–45. Scholar
  60. Korpi A, Pasanen A-L, Pasanen P (1998) Volatile s. Appl Environ Microbiol 64(8):2914–2919Google Scholar
  61. Lacourt A, Pintos J, Lavoué J, Richardson L, Siemiatycki J (2015) Lung cancer risk among workers in the construction industry: results from two case–control studies in Montreal. BMC Public Health 15:941. Scholar
  62. Langston MA, Levine RS, Kilbourne BJ, Rogers GL, Kershenbaum AD, Baktash SH, Coughlin SS, Saxton AM, Agboto VK, Hood DB, Litchveld MY, Oyana TJ, Matthews-Juarez P, Juarez PD (2014a) Scalable combinatorial tools for health disparities research. Int J Environ Res Public Health 11(10):10419–10443. Scholar
  63. Langston MA, Levine RS, Kilbourne BJ, Rogers GL, Kershenbaum AD, Baktash SH, Coughlin SS, Saxton AM, Agboto VK, Hood DB, Litchveld MY, Oyana TJ, Matthews-Juarez P, Juarez PD (2014b) Scalable combinatorial tools for health disparities research. Int J Environ Res Public Health 11(10):10410–10413CrossRefGoogle Scholar
  64. Latifovic L, Villeneuve PJ, Parent MÉ, Johnson KC, Kachuri L, Canadian Cancer Registries Epidemiology Group, Harris SA (2015) Bladder cancer and occupational exposure to diesel and gasoline engine emissions among Canadian men. Cancer Med 4(12):1948–1962. Scholar
  65. Lee ACK, Jordan HC, Horsley J (2015) Value of urban green spaces in promoting healthy living and wellbeing: prospects for planning. Risk Manag Healthc Policy 8:131–137. Scholar
  66. Lee D, Shaddick G (2010) Spatial modeling of air pollution in studies of its short-term health effects. Biometrics 66:1238–1246. Scholar
  67. Lentz TJ, Dotson GS, Williams PR, Maier A, Gadagbui B, Pandalai SP, Lamba A, Hearl F, Mumtaz M (2015) Aggregate exposure and cumulative risk assessment—integrating occupational and non-occupational risk factors. J Occup Environ Hyg 12(sup1):S112–S126. Scholar
  68. Lepeule J, Laden F, Dockery D, Schwartz J (2012) Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard six cities study from 1974 to 2009. Environ Health Perspect 120:965–970. Scholar
  69. Levy JI, Hanna SR (2011) Spatial and temporal variability in urban fine particulate matter concentrations. Environ Pollut 159:2009–2015. Scholar
  70. Liu H, Li F, Li J, Zhang Y (2017) The relationships between urban parks, residents’ physical activity, and mental health benefits: a case study from Beijing, China. J Environ Manag 190:223–230. Scholar
  71. Lobdell DT, Jagai JS, Rappazzo K, Messer LC (2011) Data sources for an environmental quality index: availability, quality, and utility. Am J Public Health 101(S1):S277–S285. Scholar
  72. Lovekamp-Swan T, Davis BJ (2003) Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect 111(2):139–145CrossRefGoogle Scholar
  73. Malambo P, Kengne AP, De Villiers A, Lambert EV, Puoane T (2016) Built environment, selected risk factors and major cardiovascular disease outcomes: a systematic review. PLoS One 11(11):e0166846. Scholar
  74. Malhotra J, Sartori S, Brennan P, Zaridze D, Szeszenia-Dabrowska N, Świątkowska B, Rudnai P, Lissowska J, Fabianova E, Mates D, Bencko V, Gaborieau V, Stücker I, Foretova L, Janout V, Boffetta P (2015) Effect of occupational exposures on lung cancer susceptibility: a study of gene–environment interaction analysis. Cancer Epidemiol Biomark Prev 24(3):570–579. Scholar
  75. Marmot M (2005) Social determinants of health inequalities. Lancet 365(9464):1099–1104. Scholar
  76. Marmot M, Ryff CD, Bumpass LL, Shipley M, Marks NF (1997) Social inequalities in health: next questions and converging evidence. Soc Sci Med 44(6):901–910. Scholar
  77. Mendell MJ, Mirer AG, Cheung K, Tong M, Douwes J (2011) Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environ Health Perspect 119(6):748–756. Scholar
  78. Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD (2007) Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 356:447–458. Scholar
  79. National Health Policy Forum (2010) Governmental public health: an overview of state and local public health agencies. BACKGROUND PAPER No. 77. George Washington UniversityGoogle Scholar
  80. National Research Council (1983) Risk assessment in the federal government: managing the process. The National Academies Press, Washington, DCGoogle Scholar
  81. National Research Council (2004) Air quality management in the United States. The National Academies Press, Washington DC. Scholar
  82. National Research Council (2012) Exposure science in the 21st century: a vision and a strategy. The National Academies Press, Washington, DCGoogle Scholar
  83. National Research Council (US) Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology (2007) Applications of toxicogenomic technologies to predictive toxicology and risk assessment. National Academies Press, Washington DCGoogle Scholar
  84. Nielsen LS, Bælum J, Rasmussen J, Dahl S, Olsen KE, Albin M, Hansen NC, Sherson D (2014) Occupational asbestos exposure and lung cancer—a systematic review of the literature. Arch Environ Occup Health 69(4):191–206. Scholar
  85. Noonan AS, Velasco-Mondragon HE, Wagner FA (2016) Improving the health of African Americans in the USA: an overdue opportunity for social justice. Public Health Rev 37(1):12. Scholar
  86. Occupational Safety and Health Administration (2017) US DOL. Accessed 14 Mar 2017
  87. Oddone E, Modonesi C, Gatta G (2014) Occupational exposures and colorectal cancers: a quantitative overview of epidemiological evidence. World J Gastroenterol: WJG 20(35):12431–12444. Scholar
  88. Olsen J, Sabroe S (1984) Occupational causes of laryngeal cancer. J Epidemiol Community Health 38(2):117–121CrossRefGoogle Scholar
  89. Pardo-Crespo MR, Narla NP, Williams AR, Beebe TJ, Sloan J, Yawn BP, Wheeler PH, Juhn YJ (2013) Comparison of individual-level versus area-level socioeconomic measures in assessing health outcomes of children in Olmsted County, Minnesota. J Epidemiol Community Health 67(4):305–310. Scholar
  90. Parent M, Siemiatycki J, Fritschi L (2000) Workplace exposures and oesophageal cancer. Occup Environ Med 57(5):325–334. Scholar
  91. Pećina-Šlaus N, Pećina M (2015) Only one health, and so many omics. Cancer Cell Int 15:64. Scholar
  92. Pesch B, Pierl CB, Gebel M, Gross I, Becker D, Johnen G, Rihs HP, Donhuijsen K, Lepentsiotis V, Meier M, Schulze J, Brüning T (2008) Occupational risks for adenocarcinoma of the nasal cavity and paranasal sinuses in the German wood industry. Occup Environ Med 65(3):191CrossRefGoogle Scholar
  93. Ruiz JDC, Quackenboss JJ, Tulve NS (2016) Contributions of a child’s built, natural, and social environments to their general cognitive ability: a systematic scoping review. PLoS One 11(2):e0147741. Scholar
  94. Samet JM, Zeger SL, Dominici F, Curriero F, Coursac I, Dockery DW, Schwartz J, Zanobetti A (2000) The national morbidity, mortality, and air pollution study. Part II: morbidity and mortality from air pollution in the United States. Res Rep Health Eff Inst 94(Pt 2):5–70Google Scholar
  95. Sexton K, Linder SH (2011) Cumulative risk assessment for combined health effects from chemical and nonchemical stressors. Am J Public Health 101(Suppl 1):S81–S88. Scholar
  96. Smith TD, DeJoy DM (2012) Occupational Injury in America: an analysis of risk factors using data from the General Social Survey (GSS). J Saf Res 43(1):67–74. Scholar
  97. Sobel E, Davanipour Z, Sulkava R, Erkinjuntti T, Wikstrom J, Henderson VW, Buckwalter G, Bowman JD, Lee P-J (1995) Occupations with exposure to electromagnetic fields: a possible risk factor for Alzheimer’s disease. Am J Epidemiol 142(5):515–524. Scholar
  98. Song W, Cao Y, Wang D, Hou G, Shen Z, Zhang S (2015) An investigation on formaldehyde emission characteristics of wood building materials in chinese standard tests: product emission levels, measurement uncertainties, and data correlations between various tests. PLoS One 10(12):e0144374. Scholar
  99. Stapleton HM, Klosterhaus S, Keller A, Ferguson PL, van Bergen S, Cooper E, Webster TF, Blum A (2011) Identification of flame retardants in polyurethane foam collected from baby products. Environ Sci Technol 45(12):5323–5331. Scholar
  100. Sun E, Shi Y (2015) MicroRNAs: small molecules with big roles in neurodevelopment and diseases. Exp Neurol 268:46–53. Scholar
  101. Surdu SFE, Bloom MS, Boscoe FP, Carpenter DO, Haase RF et al (2013) Occupational exposure to ultraviolet radiation and risk of non-melanoma skin cancer in a multinational European study. PLoS One 8(4):e62359. Scholar
  102. Syed ST, Gerber BS, Sharp LK (2013) Traveling towards disease: transportation barriers to health care access. J Community Health 38(5):976–993. Scholar
  103. Tarvainen L, Kyyrönen P, Kauppinen T, Pukkala E (2008) Cancer of the mouth and pharynx, occupation and exposure to chemical agents in Finland [in 1971–95]. Int J Cancer 123:653–659CrossRefGoogle Scholar
  104. U.S. Census Bureau (2014) American community survey design and methodology. Accesed 14 Mar 2017
  105. U.S. Census Bureau (2017) My congressional district. Accessed 14 Mar 2017
  106. UC Berkeley Safe Transportation Research and Education Center (2017) Berkeley SafeTREC. Accessed 14 Mar 2017
  107. United States Comptroller General (1977) National water quality goals cannot be attained without attention to pollution from diffused or “nonpoint” sources. vol Rep. CED-78-6 USGO, Washington, DCGoogle Scholar
  108. Urban Institute and Brookings Institution (2017) State (and Local) Taxes. Accessed 14 Mar 2017
  109. USDHHS (2017) Health information privacy. Accessed 14 Mar 2017
  110. USEPA (2003) Framework for cumulative risk assessmen. EPA, Washington DCGoogle Scholar
  111. USEPA (2017a) Carbon monoxide’s impact on indoor air quality. USEPA. Accessed 14 Mar 2017
  112. USEPA (2017b) Exposure assessment tools by media—water and sediment. Accessed 14 Mar 2017
  113. USEPA (2017c) The inside story: a guide to indoor air quality. Accessed 14 Mar 2017
  114. USEPA (2017d) Particulate matter (PM) pollution. Accessed 14 Mar 2017
  115. USEPA (2017e) Sulfur dioxide (SO2) pollution. Accessed 14 Mar 2017
  116. USEPA (2017f) Types of pesticide ingredients. USEPA. Accessed 14 Mar 2017
  117. USGPO (2017) Electronic code of federal regulations. Accessed 14 Mar 2017
  118. USGS (2017) NLCD 92 land cover class definitions. Accessed 14 Mar 2017
  119. Volchek K, Thouin G, Kuang W, Li K, Tezel FH, Brown CE (2014) The release of lindane from contaminated building materials. Environ Sci Pollut Res Int 21(20):11844–11855. Scholar
  120. Wang Y, Eliot MN, Wellenius GA (2014) Short-term changes in ambient particulate matter and risk of stroke: a systematic review and meta-analysis. J Am Heart Assoc 3(4):e000983. Scholar
  121. Wells NM (2017) How natural and built environments impact human health. Accessed 14 Mar 2017
  122. Wild CP (2005) Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomark Prev 14(8):1847–1850CrossRefGoogle Scholar
  123. Wild CP (2012) The exposome: from concept to utility. Int J Epidemiol 41(1):24–32. Scholar
  124. Williams D (1990) Socioeconomic differentials in health: a review and redirection. Soc Psychol Q 53(2):81–99CrossRefGoogle Scholar
  125. Williams PRD, Dotson GS, Maier A (2012) Cumulative risk assessment (CRA): transforming the way we assess health risks. Environ Sci Technol 46(20):10868–10874. Scholar
  126. Wimalawansa SA, Wimalawansa SJ (2016) Environmentally induced, occupational diseases with emphasis on chronic kidney disease of multifactorial origin affecting tropical countries. Ann Occup Environ Med 28:33. Scholar
  127. World Health Organization (2017) Social determinants of health. Accessed 14 Mar 2017
  128. Yang S-N, Hsieh C-C, Kuo H-F, Lee M-S, Huang M-Y, Kuo C-H, Hung C-H (2014) The effects of environmental toxins on allergic inflammation. Allergy, Asthma Immunol Res 6(6):478–484. Scholar
  129. Zhang LJ, Zheng JY, Yin SS, Peng K, Zhong LJ (2010) Development of non-road mobile source emission inventory for the Pearl River Delta region. Huan Jing Ke Xue 31(4):886–891Google Scholar
  130. Zhao X, Wang H, Li J, Shan Z, Teng W, Teng X (2015) The correlation between polybrominated diphenyl ethers (PBDEs) and thyroid hormones in the general population: a meta-analysis. PLoS One 10(5):e0126989. Scholar
  131. Zimmer KE, Gutleb AC, Ravnum S, Krayer von Krauss M, Murk AJ, Ropstad E, Skaare JU, Eriksen GS, Lyche JL, Koppe JG, Magnanti BL, Yang A, Bartonova A, Keune H (2012) Policy relevant results from an expert elicitation on the health risks of phthalates. Environ Health 11(Suppl 1):S6–S6. Scholar

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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Family and Community Medicine, Health Disparities Research Center of ExcellenceMeharry Medical CollegeNashvilleUSA

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