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Gene Therapy in Cartilage Repair and Regeneration

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Gene Therapy in Reconstructive and Regenerative Surgery

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Abstract

Clinical and translational research for the treatment of articular cartilage disease and injury has demonstrated a continued need for the development of molecular approaches in the last decade. New technological breakthroughs in combining gene and cell therapy have revolutionized cartilage regeneration, resulting in advances never before thought possible. This review covers recent progress in recombinant adeno-associated viral (rAAV) vector-mediated approaches for gene and cell therapy in vivo and ex vivo. In particular, we will discuss the application of the AAV vector for in vivo gene therapy and AAV-based genetic modification of stem cells ex vivo. Moreover, we will also discuss the various approaches to clinical trials.

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Acknowledgments

We gratefully acknowledge Ms. Anna T. Dzuricky, University of Pittsburgh Swanson School of Engineering, for reviewing and editing this manuscript.

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Authors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Sheri Wang

  2. Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Bing Wang

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  1. Sheri Wang
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Correspondence to Bing Wang .

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Editors and Affiliations

  1. Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Giorgio Giatsidis

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Wang, S., Wang, B. (2018). Gene Therapy in Cartilage Repair and Regeneration. In: Giatsidis, G. (eds) Gene Therapy in Reconstructive and Regenerative Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-78957-6_5

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  • DOI: https://doi.org/10.1007/978-3-319-78957-6_5

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