Abstract
A rotational symmetric finite element model is constructed to simulate the release of moxifloxacin from different types of plasma-grafted intraocular lenses, utilizing general discontinuous boundary conditions to describe the interface between lens and outside medium. Such boundary conditions allow for the modelling of partitioning and interfacial mass transfer resistance. Due to its rotational symmetry, the shape of the optical part of the intraocular lens is fully taken into account.
Two types of polyacrylates were plasma-grafted to the intraocular lens to act as barriers for the release of the loaded drug. Simulations are carried out and compared to release experiments to infer drug-material properties, which is crucial for optimising therapeutic effects.
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Acknowledgments
We thank financial support from the Technical Development Fund, Iceland, (grant no. 13-1309), and Fundação para a Ciência e a Tecnologia (FCT, Portugal), QREN, POFC-COMPETE and FEDER programmes (grants M-ERA.NET/0005/2012 and M-ERA.NET/0006/2012), as part of the jointly funded European M-Era.Net project titled “SurfLenses - Surface modifications to control drug release from therapeutic ophthalmic lenses”. P. Alves and P. Coimbra thank FCT for personal grants SFRH/BPD/69410/2010 and SFRH/BPD/73367/2010, respectively. All authors thank Dr. Helena Filipe (Hospital das Forças Armadas, Lisbon, Portugal) for advice, and Dr. Dimitriya Bozukova (PhysIOL, S. A., Liège, Belgium) also for advice and for supplying the IOLs.
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Gudnason, K. et al. (2018). Modelling the Release of Moxifloxacin from Plasma Grafted Intraocular Lenses with Rotational Symmetric Numerical Framework. In: Rojas, I., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2018. Lecture Notes in Computer Science(), vol 10813. Springer, Cham. https://doi.org/10.1007/978-3-319-78723-7_28
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DOI: https://doi.org/10.1007/978-3-319-78723-7_28
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