Skip to main content

Red Blood Cell Model Validation in Dynamic Regime

  • Conference paper
  • First Online:
Bioinformatics and Biomedical Engineering (IWBBIO 2018)


Our work is set in the area of microfluidics, and deals with behavior of fluid and blood cells in microfluidic devices. The aim of this article is to validate our numerical model of red blood cell. This is done by comparing computer simulation with existing laboratory experiment. The experiment is exploring the velocity and deformation of blood cells in a hyperbolic microchannel. Our research confirms that the deformation of the red blood cell in the simulation is comparable with the results from the experiment, as long as the fluid velocity profile in the simulation fits the fluid velocity profile of the experiment. This validates the elastic parameters of the red blood cell model.

K. Kovalčíková, A. Bohiniková, M. Slavík and I. Cimrák—This work was supported by the Ministry of Education, Science, Research and Sport of the Slovak Republic under the contract No. VEGA 1/0643/17 and by the Slovak Research and Development Agency under the contract No. APVV-15-0751.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions


  1. Rodriguez, R.O., Pinho, D., Faustino, V., Lima, R.: A simple microfluidic device for the deformability assessment of blood cells in a continuous flow. Biomed. Microdevices 17, 108 (2015)

    Article  Google Scholar 

  2. Cimrák, I., Gusenbauer, M., Schrefl, T.: Modelling and simulation of processes in microfluidic devices for biomedical applications. Comput. Math. Appl. 64(3), 278–288 (2012)

    Article  MathSciNet  MATH  Google Scholar 

  3. Cimrák, I., Gusenbauer, M., Jančigová, I.: An ESPResSo implementation of elastic objects immersed in a fluid. Comput. Phys. Commun. 185(3), 900–907 (2014)

    Article  MATH  Google Scholar 

  4. Dao, M., Lim, C.T., Suresh, S.: Mechanics of the human red blood cell deformed by optical tweezers. J. Mech. Phys. Solids 51(11), 2259–2280 (2003)

    Article  Google Scholar 

  5. Dao, M., Li, J., Suresh, S.: Molecularly based analysis of deformation of spectrin network and human erythrocyte. Mater. Sci. Eng. C 26(8), 1232–1244 (2005)

    Article  Google Scholar 

  6. Ahlrichs, P., Dnweg, B.: Lattice-Boltzmann simulation of polymer-solvent systems. Int. J. Mod. Phys. C 9(08), 1429–1438 (2003)

    Article  Google Scholar 

  7. Ondrušová, M.: Sensitivity of red blood cell dynamics in a shear flow. Cent. Eur. Res. J. 3(1), 28–33 (2017)

    Google Scholar 

  8. Bušík, M.: Development and optimization model for flow cells in the fluid. [Dissertation thesis] - University of Žilina. Faculty of Management Science and Informatics. Department of Software Technology. Supervisor: doc. Mgr. Ivan Cimrák, Dr. Žilina, FRI ZU, 114 p. (2017)

    Google Scholar 

  9. Bachratá, K., Bachratý, H.: On modeling blood flow in microfluidic devices. In: 10th International Conference on ELEKTRO 2014, Slovakia, pp. 518–521. IEEE (2014)

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kristína Kovalčíková .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Kovalčíková, K., Bohiniková, A., Slavík, M., Mazza Guimaraes, I., Cimrák, I. (2018). Red Blood Cell Model Validation in Dynamic Regime. In: Rojas, I., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2018. Lecture Notes in Computer Science(), vol 10813. Springer, Cham.

Download citation

  • DOI:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-78722-0

  • Online ISBN: 978-3-319-78723-7

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics