Sepsis in Pregnancy

  • Derek J. TuffnellEmail author


Sepsis is the systemic effect of infection. It is a significant cause of maternal death. Severe sepsis occurs in around 1 in 2000 pregnancies with septic shock occurring in around 1 in 10,000 pregnancies. It is an important cause of maternal mortality and morbidity but also has fetal implications as maternal infection, particularly around the time of labour can also be associated with adverse fetal outcome. Whilst there is clear evidence that the prompt treatment of maternal infection can improve maternal outcomes the evidence for the improvement of fetal outcomes is more difficult. Litigation in relation to sepsis focuses upon whether the infection could have been prevented, whether it was suspected or identified at an early enough point and then whether the treatment support and source control of infection were managed in an appropriate way. These matters will be considered.


Sepsis in pregnancy Infection in pregnancy Puerperal sepsis Antibiotics Septic shock Intra-partum prophylaxis Litigation 


  1. 1.
    National Institute for clinical excellence (NICE) Clinical guidelines CG312. Caesarean section. Published 23 Nov 2011.Google Scholar
  2. 2.
    Kenyon SL, et al. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. The Lancet. 357(9261):979–88.CrossRefGoogle Scholar
  3. 3.
    Royal College of Obstetricians and Gynaecologists (RCOG). Green-top Guideline No. 29. The management of third and fourth degree perineal tears. 2015.Google Scholar
  4. 4.
    Hughes RG, Brocklehurst P, Stee r PJ, Heath P, Stenson BM, On behalf of the Royal College of Obstetricians and Gynaecologists. Prevent ion of early-onset neonatal group B streptococcal disease. Green-top guideline no. 36. BJOG. 2017;124(12):e280–305. Scholar
  5. 5.
    National perinatal epidemiology unit (NPEU). ANODE: prophylactic antibiotics for the prevention of infection following operative delivery.Google Scholar
  6. 6.
    Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580–637.CrossRefGoogle Scholar
  7. 7.
    Royal College of Obstetricians and Gynaecologists (RCOG). Green-top guideline No.64a. Bacterial sepsis in pregnancy. 2012.Google Scholar
  8. 8.
    Royal College of Obstetricians and Gynaecologists (RCOG). Green-top guideline No.64b. Bacterial sepsis following pregnancy. 2012.Google Scholar
  9. 9.
    Nice clinical guideline CG70. Inducing labour. Published 23rd July 2008.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Obstetrics and GynaecologyBradford Teaching Hospitals NHS Foundation TrustBradfordUK

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