A Comparison Between Threshold Ergodic Sets and Stochastic Simulation of Boolean Networks for Modelling Cell Differentiation
Recently a cell differentiation model based on noisy random Boolean networks has been proposed. This mathematical model is able to describe in an elegant way the most relevant features of cell differentiation. Noise plays a key role in this model; the different stages of the differentiation process are emergent dynamical configurations deriving from the control of the intracellular noise level. In this work we compare two approaches to this cell differentiation framework: the first one (already present in the literature) is focused on a network analysis representing the average wandering of the system among its attractors, whereas the second (new) approach takes into consideration the dynamical stories of thousands of individual cells. Results showed that under a particular noise condition the two approaches produce comparable results. Therefore both can be used to model the cell differentiation process in an integrative and complementary manner.
- 2.Benedettini, S., Roli, A., Serra, R., Villani, M.: Automatic design of Boolean networks for modelling cell differentiation. In: Cagnoni, S., Mirolli, M., Villani, M. (eds.) Evolution, Complexity and Artificial Life, vol. 708, pp. 77–89. Springer, Heidelberg (2014). https://doi.org/10.1007/978-3-642-37577-4_5CrossRefGoogle Scholar
- 7.Milo, R., Jorgensen, P., Moran, U., Weber, G., Springer, M.: Bionumbers-the database of key numbers in molecular and cell biology. Nucleic Acids Res. 38(Suppl. 1), D750–D753 (2009)Google Scholar