Antimicrobial Resistance Among Streptococcus pneumoniae

  • Catia Cillóniz
  • Carolina Garcia-Vidal
  • Adrian Ceccato
  • Antoni Torres
Part of the Emerging Infectious Diseases of the 21st Century book series (EIDC)


Antibiotic resistance in Streptococcus pneumoniae (pneumococcus), the main pathogen responsible for community-acquired pneumonia (CAP), meningitis, bacteremia, and otitis media, is a major concern for clinicians. This pathogen is associated with high rates of morbidity and mortality, especially among children under 2 years old, immunocompromised persons, and the elderly population. The major anti-pneumococcus agents are β-lactams and macrolides, with fluoroquinolones ranking third. The emergence of antibiotic-resistant pneumococcus due to overuse of antibiotics is a global concern. While the discovery of novel classes of antibiotics for the pneumococcus is at a standstill, significant progress in reducing the problem of resistance is associated with antibacterial vaccines. Nevertheless, the World Health Organization recently considered drug-resistant S. pneumoniae as ranking among the 12 bacteria, for which there is an urgent need for new treatments. A challenge is to slow the evolution of new strains that are resistant to the vaccines.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Catia Cillóniz
    • 1
  • Carolina Garcia-Vidal
    • 2
  • Adrian Ceccato
    • 3
  • Antoni Torres
    • 1
  1. 1.Department of PneumologyInstitut Clinic del Tórax, Hospital Clinic of Barcelona – Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB) – SGR 911 – Ciber de Enfermedades Respiratorias (Ciberes)BarcelonaSpain
  2. 2.Infectious Disease DepartmentHospital Clinic of BarcelonaBarcelonaSpain
  3. 3.Department of PneumologyHospital Nacional Alejandro PosadasPalomarArgentina

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