Microspheres of polymethylmethacrylate (PMMA) have been injected beneath wrinkles and for facial volume augmentation since 1990 in more than 500,000 patients worldwide. They remain in the body permanently and are as safe as hyaluronic acid injections if injected strictly subdermally and epiperiosteally. Most serious complications occur after intra-arterial injections, and most nodules form after intramuscular injections. Foreign body granulomas are rare but can occur years after injection of PMMA subsequently to a systemic bacterial infection.
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Lemperle, G. (2020). Polymethylmethacrylate Microsphere Injections in the Face. In: Costa, A. (eds) Minimally Invasive Aesthetic Procedures . Springer, Cham. https://doi.org/10.1007/978-3-319-78265-2_81
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Print ISBN: 978-3-319-78264-5
Online ISBN: 978-3-319-78265-2