Related Topics in Calorimetry
Many analytical applications of titration calorimetry were developed beginning in the 1960s when thermistors became available. Thermistors, with time constants <1 s and sufficient sensitivity to resolve a few micro-degrees, provided a convenient way to make rapid measurements of temperature that made continuous titration and single injection methods of analysis feasible with very simple equipment. These methods, variously known as thermometric titration, enthalpy titration, enthalpic injection, calorimetric titration, etc., were the forerunners to what eventually became known as isothermal titration calorimetry (ITC). In the titration methods, endpoints and thence concentrations of reactants are indicated by a change in heat production. In the injection methods, the measured amount of heat is divided by the ΔrH value to determine the amount of analyte. Several articles and reviews on analytical applications of titration calorimetry are given in the bibliography.
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