Introduction: Motivations for Next-Generation ADCs

  • Marc Damelin
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The new and emerging ADC technologies together with the field’s cumulative experience provide new opportunities for ADCs and make them a more promising therapeutic modality than ever before. Despite a rapidly evolving clinical landscape in oncology, there is substantial unmet clinical need that could be addressed by next-generation ADCs. ADCs are also being explored to combat other diseases. This introductory chapter provides context for the key innovations of next-generation ADCs described throughout the volume. A framework for designing and interpreting preclinical pharmacology studies is proposed such that emerging technologies can be rigorously evaluated and molecules can be judiciously optimized.


Preclinical studies In vivo Pharmacology Oncology Challenge Innovation Tool Technology Patient-derived xenograft PDX 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Marc Damelin
    • 1
  1. 1.Mersana Therapeutics, Inc.CambridgeUSA

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