Toxin- and Drug-Induced Pathologies

  • Reinhard B. Dettmeyer
Chapter

Abstract

Numerous toxins can cause histopathological findings, some of which are considered highly characteristic for the ingestion of a particular toxin. Alongside the wide spectrum of drug reactions, including drug-induced fatal myocarditis (e.g., following diclofenac or clozapine use), ethylene glycol poisoning accompanied by the development of oxalate nephropathy and fungal poisoning involving massive hepatic necrosis are also worthy of note here. Antibiotic-induced pseudomembranous colitis and toxic epidermal necrolysis (Lyell’s syndrome) can also be mentioned here. Although anabolic steroid abuse may cause less specific histopathological findings, when taken together, these are nevertheless useful in terms of expert opinions. Allergic drug reactions may result in unspecific findings that can only be interpreted in conjunction with the detection of a particular drug. The same applies to microscopy findings in colchicine intoxication. In individual cases, drug intolerance may trigger anaphylactic shock. Although histological findings following the ingestion of heavy metals have been described in the literature, these are rarely seen in routine practice. Rarer intoxications are seen in conjunction with suicides, e.g., using English yew (Taxus baccata) or tobacco. If substances of this kind have been ingested, the microscopic examination of gastric contents can be extremely helpful.

References

  1. Abrahams C, Wheatley A, Rubenstein AH, Stables D (1964) Hepatocellular lipofuscin after excessive ingestion of analgesics. Lancet 2:621–622PubMedGoogle Scholar
  2. Adair TW, Dobersen MJ, Lear-Kaul K (2007) Appearance of chemical burns resulting from the washing of a deceased body with bleach. J Forensic Sci 52:709–711PubMedGoogle Scholar
  3. Adebahr G (1960) Nierenveränderungen bei der E 605-Vergiftung des Menschen. Arch Toxikol 18:107PubMedGoogle Scholar
  4. Adebahr G (1963) Leberveränderungen bei der E 605-Vergiftung des Menschen. Beitr Gerichtl Med 22:1Google Scholar
  5. Adebahr G (1976) Zur Pathologie der Organschäden nach diagnostischen und therapeutischen Eingriffen. Z Rechtsmed 78:173PubMedGoogle Scholar
  6. Adebahr G, Voigt GE (1963) Morphologische Veränderungen bei der akuten tödlichen Nicotinvergiftung. Dtsch Z f gerichtl Med 54:304Google Scholar
  7. Aderjan R, Joachim H (1988) Ethylene glycol intoxication with fatal outcome. Z Rechtsmed 100:199–206PubMedGoogle Scholar
  8. Advenier AS, Dorandeu A, Charlier P, Lorin de la Grandmaison G (2014) Microscopic acute lesions after caustic exposure. Forensic Sci Int 234:57–63PubMedGoogle Scholar
  9. Ali-Cherif A, Royere ML, Gosset A, Poncet M, Salomon G, Khalil R (1984) Behavior and mental activity disorders after carbon monoxide poisoning. Bilateral pallidal lesions. Rev Neurol 140:401–405PubMedGoogle Scholar
  10. Allender WJ (1982) Colchicine poisoning as a mode of suicide. J Forensic Sci 27:944–947PubMedGoogle Scholar
  11. Altmann HW, Klinge O (1972) Morphologische Reaktionen menschlichen Lebergewebes auf Pharmaka. Verh Dtsch Ges Pathol 56:194–214PubMedGoogle Scholar
  12. Amadasi A, Mastrolucca L, Marasciuolo L, Caligara M, Sironi L, Gentile G, Zoja R (2015) Death due to acute tetrachloroethylene intoxication in a chronic abuser. Int J Legal Med 129:487–493PubMedGoogle Scholar
  13. Amitai Y, Withesell L, Lovejoy FH (1986) Death following accidental overdose in a child. N Engl J Med 314:182–183PubMedGoogle Scholar
  14. Ammar KA, Heckerling PS (1996) Ethylene glycol poisoning with a normal anion gap caused by concurrent ethanol ingestion: importance of the osmolal gap. Am J Kidney Dis 27:130–133PubMedGoogle Scholar
  15. Aquila I, Pepe F, di Nunzio C, Ausania F, Serra A, Ricci P (2014) Suicide case due to phosphoric acid ingestion: case report and review of literature. J Forensic Sci 59:1665–1667PubMedGoogle Scholar
  16. Armstrong EJ, Engelhart DA, Jenkins AJ, Balraj EK (2006) Homicidal ethylene glycol intoxication: a report of a case. Am J Forensic Med Pathol 27:151–155PubMedGoogle Scholar
  17. Arsenovic N, Sheehan L, Clark D, Moreira R (2010) Fatal carbamazepine induced fulminant eosinophilic (hypersensitivity) myocarditis: emphasis on anatomical and histological characteristics, mechanisms and genetics of drug hypersensitivity and differential diagnosis. J Forensic Legal Med 17:57–61Google Scholar
  18. Arzneimittelkommission der Deutschen Ärzteschaft (2016) Fulminante Myokarditis mit akuter kardialer Dekompensation nach Erstgabe von Adalimumab (Humira®) bei Colitis ulcerosa. Deutsches Ärzteblatt 113:B579–B580Google Scholar
  19. Asano S, Wakasaka H, Kaise S, Nishimaki T, Kasukawa R (1982) Peliosis hepatis. Report of two autopsy cases with a review of literature. Acta Pathol Jpn 32:861–877PubMedGoogle Scholar
  20. Asbeck F, Joist H, Löhrs U (1972) Lebervenenthrombose und Ovulationshemmer. Ein weiterer Fall von Budd-Chiari-Syndrom nach Einnahme eines oralen Kontrazeptivums. Med Klin 67:82PubMedGoogle Scholar
  21. Axelsson B, Piscator M (1966) Nierenschädigung nach längerer Cadmiumexposition. Experimentelle Untersuchungen. Arch Environ Health 12:360PubMedGoogle Scholar
  22. Bagheri SA, Boyer JL (1974) Peliosis hepatis associated with androgenic-anabolic steroid therapy. Ann Intern Med 81:610–680PubMedGoogle Scholar
  23. Barthel J, Gerber HU (1962) Ein Beitrag zur Vergiftung mit Wasserschierling (Cicuta virosa L.) bei Kindern. Kinderärztl Prax Sonderdruck 12:543–547Google Scholar
  24. Baumgarten R, Fengler JD, Bartke D, Roschlau G, May D (1981) Peliosis hepatis – eine seltene Form der arzneimittelinduzierten Leberschädigung. Dtsch Gesundh Wes 23:629–631Google Scholar
  25. Behrend H (1977) Myocardial cell lesions caused by an anabolic hormone. Cell Tissue Res 181:423–426Google Scholar
  26. Berneis K, Studer A (1967) Vermehrung von Lipofuscin in der Leber als Folge von Phenacetinabusus. Zentrifugation von menschlicher und tierischer Leber im Dichtegradienten. Virchows Arch Pathol Anat 343:75–80Google Scholar
  27. Bianchi L, De Groote J, Desmet V, Gedigk P, Korb G, Popper H, Poulsen H, Scheuer PJ, Schmid M, Thaler H, Wepler W (1975) Richtlinien für die histologische Beurteilung arzneimittelbedingter (medikamentöser) Leberschäden. Dtsch Med Wochenschr 100:1746–1750PubMedGoogle Scholar
  28. Bianco F, Floris R (1996) MRI appearance consistent with haemorrhagic infarction as an early manifestation of carbon monoxide poisoning. Neuroradiology 38(suppl 1):S70PubMedGoogle Scholar
  29. Bommer J, Waldherr R, Gastner M, Lemmes R, Ritz E (1981) Iatrogenic multiorgan silicone inclusions in dialysis patients. Klin Wochenschr 59:1149–1157PubMedGoogle Scholar
  30. Bommer J, Waldherr R, Ritz E (1983) Silicone storage disease in long-term hemodialysis patients. Contrib Nephrol 36:115–126PubMedGoogle Scholar
  31. Borchard F, Grabensee B, Jax W, Huth F (1974) Morphologische Befunde bei Paraquatvergiftungen. Klin Wochenschr 52:657PubMedGoogle Scholar
  32. Bowman SJ (1989) Anabolic steroids and infarction. Br Med J 299:632Google Scholar
  33. Brahmi N, Kouraichi N, Blei Y et al (2006) Acute myocarditis and myocardial infarction induced by paraphenylenediamine poisoning. Int J Cardiol 113:93–95Google Scholar
  34. Burck HC, Potwich F (1964) Akute Niereninsuffizienz nach schwerer Kohlenmonoxyd-Intoxikation. Frankfurt Z Path 73:520PubMedGoogle Scholar
  35. Burger R, Marcuse P (1952) Peliosis hepatis: report of a case. Am J Clin Pathol 2:569–573Google Scholar
  36. Bux R, Stengel PD, Schnabel A (2006) Dermal lesions after post mortem petrol-exposure. Forensic Sci Int 163:115–118PubMedGoogle Scholar
  37. Byard RW, Musgrave I (2010) Herbal medicines and forensic investigations. Forensic Sci Med Pathol 6:81–82PubMedGoogle Scholar
  38. Calderon JJ, Cualla U (1964) Ein interessanter Fall von Fluorvergiftung. Rev Med Legae Colomb 17(89):145Google Scholar
  39. Caparros-Lefebvre D, Policard J, Sengler C, Benabdallah E, Colombani S, Rigal M (2005) Bipallidal haemorrhage after ethylene glycol intoxication. Neuroradiology 47:105–107PubMedGoogle Scholar
  40. Carson DJ, Carson ED (1976) The increasing use of paraquat as a suicidal agent. Forensic Sci 7:151–160PubMedGoogle Scholar
  41. Cavender FL, Sowinski EJ (2001) Glycols. In: Bingham E, Cohrssen B, Powell CH (eds) Pattys toxicology, 5th edn. Wiley, New York, pp 1–71Google Scholar
  42. Centini F, Fiore C, Riezzo I, Rossi G, Fineschi V (2007) Suicide due to oral ingestion of lidocaine: a case report and review of the literature. Forensic Sci Int 171:57–62PubMedGoogle Scholar
  43. Chang Y, Wen J, Cai J, Xiao-ying W, Yang L, Guo Y (2012) An investigation and pathological analysis of two fatal cases of cadmium. Forensic Sci Int 220:e5–e8PubMedGoogle Scholar
  44. Clevenger CV, August TF, Shaw LM (1991) Colchicine poisoning: report of a fatal case with body fluid analysis by GC/MS and histopathologic examination of post-mortem tissues. J Anal Toxicol 15:151–154PubMedGoogle Scholar
  45. Cochran AJ, Watson AA (1969) Leberveränderungen bei einem Patienten nach Behandlung mit Cytostatica, ähnlich denjenigen bei akuter Phosphorvergiftung. Med Sci Law 9:202PubMedGoogle Scholar
  46. Creagh TM, Rubin A, Evans DJ (1988) Hepatic tumors induced by anabolic steroids in an athlete. J Clin Pathol 41:441–443PubMedPubMedCentralGoogle Scholar
  47. Dämmrich J, Ormanns W (1982) Lyell-Syndrom und nekrotisierende granulomatöse Arteriitis als gleichzeitige, arzneimittelbedingte Reaktionen. Pathologe 3:352–358PubMedGoogle Scholar
  48. Darke S, Torok M, Duflou J (2014) Sudden or unnatural deaths involving anabolic-androgenic steroids. J Forensic Sci 59:1025–1028PubMedGoogle Scholar
  49. Delage C, Irey NS (1972) Anaphylactic deaths: a clinicopathologic study of 43 cases. J Forensic Sci 17:525–540PubMedGoogle Scholar
  50. Desilva MB, Mueller PS (2009) Renal consequences of long-term, low-dose intentional ingestion of ethylene glycol. Ren Fail 31:586–588PubMedGoogle Scholar
  51. Dettling A, Stadler K, Eisenbach C, Skopp G, Haffner HT (2016) Systemic inflammatory response due to chloroform intoxication – an uncommon complication. Int J Legal Med 130:401–404PubMedGoogle Scholar
  52. Dettling M, Cascorbi I, Hellweg R, Deicke U, Weise L, Müller-Oerlinghausen B (1999) Genetic determinants of drug-induced agranulocytosis: potential risk of olanzapine? Pharmacopsychiatry 32:110–112PubMedGoogle Scholar
  53. Dölle W, Martini GA (1962) Zusammenstellung von Arzneimitteln, die Leberschädigung mit und ohne Gelbsucht verursachen können. Acta Hepatol Splen 9:74–85Google Scholar
  54. Edston E, van Hage-Hamsten M (1995) Immunoglobulin E, mast cell-specific tryptase and the complement system in sudden death from coronary artery thrombosis. Int J Cardiol 52:77–81PubMedGoogle Scholar
  55. Edston E, van Hage-Hamsten M (1998) Beta-Tryptase measurements post-mortem in anaphylactic deaths and in controls. Forensic Sci Int 93:135–142PubMedGoogle Scholar
  56. Eisenmenger W, Henn R, Beckmann G (1974) Klinische und pathologisch-anatomische Befunde der Paraquat-Vergiftung. Beitr Ger Med 32:262–266Google Scholar
  57. Evans GW, Philipps G, Mukherjee TM, Snow MR, Lwarence JR, Thomas DW (1973) Identification of crystal deposits in brain and kidney after xylitol administration by biochemical, histochemical, and electron diffraction methods. J Clin Pathol 26:32–36PubMedPubMedCentralGoogle Scholar
  58. Fazekas IG (1957) Tödliche Pyramidonvergiftung bei einem Säugling mit besonderer Berücksichtigung der histologischen Veränderungen. Dtsch Z f gerichtl Med 47:374Google Scholar
  59. Fazekas IG (1971) Über die makroskopischen und mikroskopischen Veränderungen bei der Wofatox-Vergiftung (Methyl-Parathion). Z Rechtsmed 68:189–194PubMedGoogle Scholar
  60. Fazekas IG, Dósa A (1953) Sektionserfahrungen bei Arsenobenzoltodesfällen. Arch f Dermatol Syph 196:288–304Google Scholar
  61. Fazekas IG, Dósa A (1954) Histologische Veränderungen bei Arsenobenzoltodesfällen und ihre Bewertung. Arch f Dermatol Syph 197:436–448Google Scholar
  62. Ferenchick GS, Adelman S (1992) Myocardial infarction associated with anabolic steroids use in a previously healthy 37-year-old weight lifter. Am Heart J 124:507–508PubMedGoogle Scholar
  63. Fineschi V, Monasterolo G, Rosi R, Turillazzi E (1999) Fatal anaphylactic shock during a fluorescein angiography. Forensic Sci Int 100:137–142PubMedGoogle Scholar
  64. Fineschi V, Cecchi R, Centini F, Reattelli LP, Turillazzi E (2001) Immunohistochemical quantification of pulmonary mast-cells and post-mortem blood dosages of tryptase and eosinophil cationic protein in 48 heroin-related deaths. Forensic Sci Int 120:189–194PubMedPubMedCentralGoogle Scholar
  65. Fineschi V, Riezzo I, Centini F, Silingardi E, Licata M, Beduschi G, Karch SB (2007) Sudden cardiac death during anabolic steroid abuse: morphologic and toxicologic findings in two fatal cases of bodybuilders. Int J Legal Med 121:48–53PubMedGoogle Scholar
  66. Finkelstein Y, Aks SE, Hutson JR et al (2010) Colchicine poisoning; the dark side of an ancient drug. Clin Toxicol (Phila) 48:407–414Google Scholar
  67. Fischer H, Kahler J (1979) Zur tödlichen Paraquatvergiftung. Z Rechtsmed 84:61–67PubMedGoogle Scholar
  68. Fitzsimons J, Berk M, Lambert T, Bourin M, Dodd S (2005) A review of clozapine safety. Expert Opin Drug Saf 4:731–744PubMedGoogle Scholar
  69. Franke W, Kyrieleis C (1976) Gewerbliche Bleivergiftung als Todesursache. Med Welt 27:233PubMedGoogle Scholar
  70. Frankle MA, Eichberg R, Zachariah SB (1988) Anabolic androgenic steroids and a stroke in an athlete: case report. Arch Phys Med Rehabil 69:632–633PubMedGoogle Scholar
  71. Frohberg K, Dorion RP, McMartin KE (2006) The role of calcium oxalate crystals deposition in cerebral vessels during ethylene glycol poisoning. Clin Toxicol 44:315–318Google Scholar
  72. Frommhold H (1964) Licht- und fluoreszenzmikroskopische Untersuchungen am Herzmuskel nach akut-tödlicher Kohlenoxydvergiftung. Med Diss. zitiert nach: Janssen 1977, HamburgGoogle Scholar
  73. Fruscella FDER (1963) Experimentelle Cadmiumpneumopathie: ein histologischer Beitrag. Rass Med Industr 32:537. (zitiert nach: Janssen 1977)PubMedGoogle Scholar
  74. Galle P, Morel-Maroger (1965) Nierenveränderungen bei klinischer und experimenteller Bleivergiftung. Nephron 2:273Google Scholar
  75. Gelven PL, Cina SJ, Lee JD, Nichols CA (1996) Massive hepatic necrosis and death following repeated isoflurane exposure. Case report and review of the literature. Am J Forensic Med Pathol 17:61–64PubMedGoogle Scholar
  76. Gilbert JD, Byard RW (2002) Epithelia cell mitotic arrest – a useful post-mortem histologic marker in cases of possible colchicine toxicity. Forensic Sci Int 126:150–152PubMedGoogle Scholar
  77. Gilbert JD, Musgrave IF, Hoban C, Byard RW (2014) Lethal hepatocellular necrosis associated with herbal polypharmacy in a patient with chronic hepatitis B infection. Forensic Sci Int 241:138–140PubMedGoogle Scholar
  78. Giusti GV, Gentile V (1974) Hyaline membrane disease in adults after artificial ventilation: a histopathologic study. Forensic Sci 4:207PubMedGoogle Scholar
  79. Gloor F (1978) Changing concepts in pathogenesis and morphology of analgesic nephropathy as seen in Europe. Kidney Int 13:27–33PubMedGoogle Scholar
  80. Gloor F (1982) Die Kapillarosklerose in den ableitenden Harnwegen bei Schmerzmittel-(Phenazetin)-Mißbrauch. Pathologe 3:132–136PubMedGoogle Scholar
  81. Gradinger R, Jung C, Reinhardt D, Mall G, Figulla HR (2008) Toxic myocarditis due to oral ingestion of hydrofluoric acid. Heart Lung Circ 17:248–250PubMedGoogle Scholar
  82. Greendyke RM, Hodge HC (1964) Unfallbedingte Todesfälle durch Fluorwasserstoff. J Forensic Sci 9:383PubMedGoogle Scholar
  83. Grobosch T, Schwarze B, Felgenhauer N, Riesselmann B, Roscher S, Binscheck T (2013) Eight cases of fatal and non-fatal poisoning with Taxus baccata. Forensic Sci Int 227:118–126PubMedGoogle Scholar
  84. Halevy S, Ghislain PD, Mockenhaupt M et al (2008) Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel. J Am Acad Dermatol 58:25–32PubMedGoogle Scholar
  85. Hallagan JB, Hallagan LF, Snyder MB (1989) Anabolic-androgenic steroid use by athletes. N Engl J Med 321:1042–1045PubMedGoogle Scholar
  86. Hallermann W, Illichmann-Christ A (1951) Die Pathologie der akuten tödlichen Ditonalvergiftung beim Kinde. Zugleich ein Beitrag zur Frage der akuten Pyramidonvergiftung und zur Entstehung kreislaufbedingter Schäden am Gehirn. Dtsch Z gerichtl Med 40:511–552Google Scholar
  87. Hallermann W, Pribilla O (1959) Tödliche Vergiftungen mit Phosphorwasserstoff. Arch Toxikol 17:219Google Scholar
  88. Hantson P, Vanbinst R, Mahieu P (2002) Determination of ethylene glycol tissue content after fatal oral poisoning and pathologic findings. Am J Forensic Med Pathol 23:159–161PubMedGoogle Scholar
  89. Hausmann R (2004) Long-term effects of anabolic-androgenic-steroid abuse. Morphological findings associated with fatal outcome. In: Tsokos M (ed) Forensic pathology reviews, vol 2. Humana, Totowa, pp 273–289Google Scholar
  90. Hecht L, Lamprecht A (2010) Intramuskuläre Applikation von Depotmedikamenten. Rechtsmedizin 20:510–514Google Scholar
  91. Herczeg E, Reif A (1968) Lungenveränderungen bei tödlich verlaufender Paraquatvergiftung. Zentralbl All Pathol 111:325–328Google Scholar
  92. Heye N, Zimmer C, Terstegge K, Sirtl C, Cervos-Navarro J (1991) Oxalate-induced encephalitis after infusions of sugar surrogates. Intensive Care Med 17:432–434PubMedGoogle Scholar
  93. Hikiji W, Kudo K, Nishida N, Ishida T, Usumoto Y, Tsuji A, Ikeda N (2008) Acute fatal poisoning with pilsicainide and atenolol. Int J Legal Med 122:503–506PubMedGoogle Scholar
  94. Hoberman LJ, Eigenbrodt EH, Kilman WJ, Hughes LR, Norgaard RP, Fordtran JS (1976) Colitis associated with oral clindamycin therapy. Dig Dis Sci 21:1–17Google Scholar
  95. Hovda KE, Guo C, Austin R, McMartin KE (2010) Renal toxicity of ethylene glycol results from internalization of calcium oxalate crystals by proximal tubule cells. Toxicol Lett 192:365–372PubMedGoogle Scholar
  96. Hübner K (1976) Morphologie der Arzneimittelschäden der Leber. Therapiewoche 26:590–604Google Scholar
  97. Iacobuzio-Donahue CA, Lee EL, Abraham SC, Yardley JH, Wu TT (2001) Colchicine toxicity: distinct morphologic findings in gastrointestinal biopsies. Am J Surg Pathol 25:1067–1073PubMedGoogle Scholar
  98. Indurato F, Raffino C, Tropea FM, Barbera N, Grieco A, Bartolini G (2014) Fatal accidental ingestion of 35% hydrogen peroxide by a 2-year-old female: a case report and literature review. Forensic Sci Med Pathol 10:443–447Google Scholar
  99. Ishida Y, Takayasu T, Kimura A, Hayashi T, Kakimoto N, Miyashita T, Kondo T (2006) Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Legal Med 8:102–109PubMedGoogle Scholar
  100. Itoh S, Igarashi M, Tsukada Y, Ichinoe A (1977) Nonalcoholic fatty liver with alcoholic hyaline after long-term glucocorticoid therapy. Acta Hepatogastroenterol Stuttg 24:415–418PubMedGoogle Scholar
  101. Jacobsen D, Akesson J, Shefter E (1982) Urinary calcium oxalate monohydrate crystals in ethylene glycol poisoning. Scand J Clin Lab Invest 146:121–234Google Scholar
  102. Janssen W (1977) Forensische histologie. Schmidt-Römhild, LübeckGoogle Scholar
  103. Janssen W, Burger E (1968) Ungewöhnliche Art einer tödlichen Vergiftung durch Kaliumzyanid mit außergewöhnlichem Organbefund. Arch Kriminol 141:99Google Scholar
  104. Jedidi M, Bel Hadj M, Masmoudi T, Abdelkarim SB, Mlayeh S, Dhiab MB, Souguir MK (2016) Fatal toxic myocarditis induced by paraphenylene diamine. A case report. Rom J Leg Med 24:17–20Google Scholar
  105. Kakar P, Millar-Craig M, Kamaruddin H, Burn S, Loganathan S (2006) Clozapine induced myocarditis: a rare but fatal complication. Int J Cardiol 112:e5–e6PubMedGoogle Scholar
  106. Kalin JR, Brissie RM (2002) A case of homicide by lethal injection with lidocaine. J Forensic Sci 47:1135–1138PubMedGoogle Scholar
  107. Kalra TM, Mangla JC, DePapp EW (1976) Benign hepatic tumors and oral contraceptive pills. Am J Med 61:871–877PubMedGoogle Scholar
  108. Karger B, Varchmin-Schultheiß K, Fechner G (2005) Fatal hepatic haemorrhage in a child-peliosis hepatis versus maltreatment. Int J Legal Med 119:44–46PubMedGoogle Scholar
  109. Kasper MR, Drebber U, Hirsch I, Dienes H (2006) Morphologische Veränderungen der medikamenteninduzierten Leberschädigung. Pathologe 27:175–181PubMedGoogle Scholar
  110. Kawamoto O, Ishikawa T, Oritani S, Kuramoto Y, Michiue T, Maeda H (2013) Death following the ingestion of detergent: an autopsy case with special regard to the histochemical findings. Forensic Sci Med Pathol 9:208–213PubMedGoogle Scholar
  111. Kendell KR, Day JD, Hruban RH et al (1995) Intimate association of eosinophils to collagen bundles in eosinophilic myocarditis and ranitidine-induced hypersensitivity myocarditis. Arch Pathol Lab Med 119:1154–1160PubMedGoogle Scholar
  112. Kennedy MC (1993) Myocardial infarction in association with misuse of anabolic steroids. Ulster Med J 62:172–174Google Scholar
  113. Kennedy MC, Lawrence C (1993) Anabolic steroid abuse and cardiac death. Med J Aust 158:346–348PubMedGoogle Scholar
  114. Kibler WB (1973) Skeletal muscle necrosis secondary to parathion. Toxicol Appl Pharmacol 25:117PubMedGoogle Scholar
  115. Kilian JG, Kerr K, Lawrence C, Celermajer DS (1999) Myocarditis and cardiomyopathy associated with clozapine. Lancet 354:1841–1845PubMedGoogle Scholar
  116. Klavis G, Schulz L (1966) Herzschäden bei der akuten Kohlenmonoxyd-Vergiftung. Arch Toxikol 21:250PubMedGoogle Scholar
  117. Klintschar M, Beham-Schmidt C, Radner H, Henning G, Roll P (1999) Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects. Forensic Sci Int 106:191–200PubMedGoogle Scholar
  118. Knudsen AH (2002) Peliosis hepatis as the cause of liver affection in a patient treated with immunosuppressive agents. Ugeskr Laeger 164:3215–3216PubMedGoogle Scholar
  119. Korb G, David H (1962) Fluoreszenzmikroskopische und elektronenoptische Untersuchungen am Herzmuskel der Ratte nach Leuchtgasvergiftungen. Dtsch Zschr f gerichtl Med 52:549Google Scholar
  120. Krähenbühl S, Kaplowitz N (1996) Drug-induced hepatotoxicity: clinical presentation, pathogenesis, risk factors, diagnosis and treatment. In: Schmidt R, Bianchi L, Blum HE, Gerok W, Maier KP, Stalder GA (eds) Acute and chronic liver diseases. Molecular biology and clinics. Kluwer, Dordrecht, pp 147–158Google Scholar
  121. Krug H (1965) Die Hirnkonsistenz bei tödlicher Kohlenmonoxydvergiftung. Dtsch Z ges gerichtl Med 56:74Google Scholar
  122. Kubic A, Burda AM, Bockewitz E, Wahl M (2009) Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hours. In: Santa Cruz DJ, Leikin JB, (eds) Seminars in diagnostic pathology. Toxicologic/Environmental Pathology. vol 26:pp 7–9PubMedGoogle Scholar
  123. La Rosée K, Schulz A, Böhm M, Erdmann E (1997) Kardiale Dekompensation eines bodybuilders. Dtsch Med Wochenschr 122:1586–1590Google Scholar
  124. Lahl R (1973) Fettembolien nach experimenteller Tetrachlorkohlenstoffintoxikation. Z Ges Inn Med 28:367PubMedGoogle Scholar
  125. Lau G (1995a) A fatal case of drug-induced multi-organ damage in a patient with Hansen’s disease: dapsone syndrome or rifampicin toxicity? Forensic Sci Int 73:109–115PubMedGoogle Scholar
  126. Lau G (1995b) Iatrogenic-related, fatal hemorrhage occurring in end-stage renal failure: a series of three cases. Forensic Sci Int 73:117–124PubMedGoogle Scholar
  127. Lau G (2005) Iatrogenic injury. A forensic perspective. In: Tsokos M (ed) Forensic pathology reviews, vol 3. Humana Press, Totowa, pp 351–439Google Scholar
  128. Layland JJ, Liew D, Prior DL (2009) Clozapine-induced cardiotoxicity: a clinical update. Med J Aust 190:192Google Scholar
  129. Lesch R (1968) Histologische und histoautoradiographische Befunde bei der experimentellen chronischen Bleivergiftung. Verh Dtsch Ges Path, p 542Google Scholar
  130. Leth PM, Gregersen M (2005) Ethylene glycol poisoning. Forensic Sci Int 155:179–184PubMedGoogle Scholar
  131. Lewis W, Silver MD (2001) Effects of drugs on the cardiovascular system. In: Silver MD, Gotlieb AI, Schoen FJ (eds) Cardiovascular pathology, 3rd edn. Churchill Livingstone, New York, pp 541–561Google Scholar
  132. Li S, Huang W, Duan Y, Xing J, Zhou Y (2015) Human fatality due to thallium poisoning: autopsy, microscopy, and mass spectrometry assays. J Forensic Sci 60:247–251PubMedGoogle Scholar
  133. Lovrić M, Granić P, Čubrilo-Turek M, Lalić Z, Sertić J (2007) Ethylene glycol poisoning. Forensic Sci Int 170:213–215PubMedGoogle Scholar
  134. Lüderwald S, Zinka B, Thieme D, Eisenmenger W (2008) Missbrauch von anabolen androgenen Steroiden. Rechtsmedizin 18:183–188Google Scholar
  135. Ludwig B, Schindler E, Bohl J, Pfeiffer J, Kremer G (1984) Reno-cerebral oxalosis induced by xylitol. Neuroradiology 26:517–521PubMedGoogle Scholar
  136. Luke JL, Farb A, Virmani R, Sample RH (1990) Sudden cardiac death during exercise in a weight lifter using anabolic androgenic steroids: pathological and toxicological findings. J Forensic Sci 35:1441–1447PubMedGoogle Scholar
  137. Lynberg K (1991) Myocardial infarction and death of a body builder after using anabolic steroids. Ugeskr Laeger 153:587–588Google Scholar
  138. Lynch ML, Woodford NWF (2008) Fatality complicating agranulocytosis in the setting of carbamazole therapy. Forensic Sci Med Pathol 4:246–249PubMedGoogle Scholar
  139. Machnik G (1985) Morphological reaction patterns of the liver induced by drugs. Zentralbl Allg Pathol 130:491–507PubMedGoogle Scholar
  140. Magdalan J, Ostrowska A, Podhorska-Okolow M, Piotrowska A, Izykowska I, Nowak M, Dolinska-Krajewska B, Zabel M, Szelag A, Dziegiel P (2009) Early morphological and functional alterations in canine hepatocytes due to a-amanitin, a major toxin of amanita phalloides. Arch Toxicol 83:55–60PubMedGoogle Scholar
  141. Mannou H, Ikemura M, Nakagawa Y, Nata M, Inoue H (2014) An autopsy case of serotonin toxicity resulting from suicidal administrations of fluvoxamine and lithium. Rom J Leg Med 22:59–62Google Scholar
  142. Markwalder C (1983) Zum morphologischen Nachweis des Mißbrauchs phenacetin-haltiger Analgetica. Beitr Gerichtl Med 41:63–66PubMedGoogle Scholar
  143. Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Müller FO (1996) Sudden death in young competitive athletes. JAMA 276:199–204PubMedGoogle Scholar
  144. McIntyre IM, Ruszkiewicz AR, Crump K, Drummer OH (1994) Death following poisoning. J Forensic Sci 39:280–286PubMedGoogle Scholar
  145. McKillop G, Todd IC, Ballantyne D (1986) Increased left ventricular mass in a body builder using anabolic steroids. Br J Sports Med 20:151–152PubMedPubMedCentralGoogle Scholar
  146. McMartin K (2009) Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning? Clin Toxicol 47:859–869Google Scholar
  147. McNutt RA, Ferenchick GS, Kirhn PC, Hamlin NJ (1988) Acute myocardial infarction in a 22-year-old worldclass weight lifter using anabolic steroids. Am J Cardiol 62:164PubMedGoogle Scholar
  148. Meatherall R, Oleschuk C (2015) Suicidal fatality from azide ingestion. J Forensic Sci 60:1666–1667PubMedGoogle Scholar
  149. Medline A, Shin DH, Medline NM (1976) Pseudomembranous colitis associated with antibiotics. Hum Pathol 7:693–703PubMedGoogle Scholar
  150. Meier W (1962) Experimentelle Untersuchungen zur Bedeutung der vacuoligen Umwandlung der Leber für die Diagnostik der Kohlenmonoxydvergiftung. Dtsch Z ges gerichtl Med 52:258Google Scholar
  151. Meissner W, Schmidt T, Kupsch A, Trottenberg T, Lempert T (1999) Reversible leucopenia related to olanzapine. Mov Disord 14:872–873PubMedGoogle Scholar
  152. Merrill DB, Dec GW, Goff DC (2005) Adverse cardiac effects associated with clozapine. J Clin Psychopharmacol 25:32–41PubMedGoogle Scholar
  153. Merrill DB, Ahmari SE, Bradford JM, Lieberman JA (2006) Myocarditis during clozapine treatment. Am J Psychiatry 163:204–208PubMedGoogle Scholar
  154. Metter D, Schulz E (1978) Tödliche Verbrühung oder Lyell-Syndrom? Z Rechtsmed 81:329–334PubMedGoogle Scholar
  155. Mihatsch MJ, Torhorst J, Amsler B, Zollinger HU (1978) Capillarosclerosis of the lower urinary tract in analgesic (phenacetin) abuse. Virchows Arch Pathol Anat 381:41–47PubMedGoogle Scholar
  156. Mihatsch MJ, Torhorst J, Steinmann E, Hofer H, Stickelberger M, Bianchi L, Berneis K, Zollinger HU (1979) The morphologic diagnosis of analgesic (phenacetin) abuse. Pathol Res Pract 164:68–79PubMedGoogle Scholar
  157. Mochizuki RM, Richter KJ (1988) Cardiomyopathy and cerebrovascular accident associated with anabolic-androgenic steroid use. Phys Sportsmed 16:108–114Google Scholar
  158. Molz G (1971) Pneumopathien bei Neugeborenen nach langfristiger intratrachealer Druckbeatmung mit hochgespanntem Sauerstoff. Beitr Gerichtl Med 28:66Google Scholar
  159. Montisci M, El Mazloum R, Cecchetto G, Terranova C, Ferrara SD, Thiene G, Basso C (2012) Anabolic androgenic steroids abuse and cardiac death in athletes: morphological and toxicological findings in four fatal cases. Forensic Sci Int 217:e13–e18PubMedGoogle Scholar
  160. Morgan JM, Hartley MW, Miller RE (1966) Nephropathie bei chronischer Bleivergiftung. Arch Intern Med 118:17PubMedGoogle Scholar
  161. Morningstar WA (1955) Exogenous hemochromatosis. Arch Pathol 59:355–358Google Scholar
  162. Movat AP (1983) Reye’s syndrome: 20 years on. Br Med J 286:1999–2000Google Scholar
  163. Muirhead EE, Crass G, Jones F, Hill JM (1949) Iron overload (Hemosiderosis) aggravated by blood transfusions. Arch Intern Med 83:477–501Google Scholar
  164. Müller GL, Graham S (1955) Intrauteriner Fruchttod durch Kohlenmonoxydvergiftung. N Engl J Med 252:1075PubMedGoogle Scholar
  165. Mullins M, Cannarozzi AA, Bailey TC, Ranganathan P (2011) Unrecognized fatalities related to colchicine in hospitalized patients. Clin Toxicol (Phila) 49:648–652Google Scholar
  166. Munk JF, Collopy BT, Connell JL, McTeigue JJ, Hughes JF, Hood RN, Breen KJ (1976) Lincomycin-clindamycin-associated pseudomembranous colitis. Med J Aust 2:95–97PubMedGoogle Scholar
  167. Nagao M, Zhang W, Itakura Y, Kobayashi M, Yamada Y, Yagi K, Oono T, Takatori T (1993) Immunohistochemical localization and dynamics of paraquat in the stomach and esophagus of rats. Int J Legal Med 106:142–144PubMedGoogle Scholar
  168. Naumann R, Felber W, Heilemann H, Reuster T (1999) Olanzapine-induced agranulocytosis. Lancet 354:566–567PubMedGoogle Scholar
  169. Nishio H, Suzuki K (2005) Three cases of suspected hyperthermia with remarkable elevation of serum mast cell tryptase. Forensic Sci Int 149:51–55PubMedGoogle Scholar
  170. Nishio H, Matsui K, Miyazaki T, Tamura A, Iwata M, Suzuki K (2002) A fatal case of amniotic fluid embolism with elevation of serum mast cell tryptase. Forensic Sci Int 126:53–56PubMedPubMedCentralGoogle Scholar
  171. Nizze H, Schwabbauer P, Brachwitz C, Lange H (1997) Fatal chronic oxalosis after sublethal ethylene glycol poisoning. Pathologe 18:328–334PubMedGoogle Scholar
  172. Norland CC, Kirsner JB (1969) Toxic dilatation of colon (toxic megacolon): etiology, treatment and prognosis in 42 patients. Medicine 48:229–250PubMedGoogle Scholar
  173. Nuzzo JL, Manz HJ, Maxted WC (1985) Peliosis hepatis after long-term androgen therapy. Urology 25:518–519PubMedGoogle Scholar
  174. Oehmichen M, Besserer K (1982) Forensic significance of acetylcholinesterase histochemistry in organophosphate intoxication. Original investigations and review of the literature. Z Rechtsmed 89:149–165PubMedGoogle Scholar
  175. Oliver RAM (1959) Siderosis following transfusions of blood. J Pathol Bacteriol 77:171–194PubMedGoogle Scholar
  176. Omer FB, Iozzo RV, Casetti P, Dellarole AC (1978) Focal nodular hyperplasia of the liver and contraceptive steroids. Acta Hepatogastroenterol 25:319–321Google Scholar
  177. Osawa M, Satoh F, Horiuchi H, Tian W, Kugota N, Hasegawa I (2008) Postmortem diagnosis of fatal anaphylaxis during intravenous administration of therapeutic and diagnostic agents: evaluation of clinical laboratory parameters and immunohistochemistry in three cases. Legal Med 10:143–147PubMedGoogle Scholar
  178. Overly WL, Dankhoff JA, Wank BK, Singh VD (1984) Androgens and hepatocellular carcinoma in an athlete. Ann Intern Med 100:158–159PubMedGoogle Scholar
  179. Parry MF, Wallach R (1974) Ethylene glycol poisoning. Am J Med 57:143–150PubMedGoogle Scholar
  180. Perskvist N, Edston E (2007) Differential accumulation of pulmonary and cardiac mast cell-subsets and eosinophils between fatal anaphylaxis and asthma death: a post-mortem comparative study. Forensic Sci Int 169:43–49Google Scholar
  181. Peter H (1955) Organbefunde nach akuter Cadmiumvergiftung. Verh Dtsch Ges Path, p 225Google Scholar
  182. Pfeiffer H, Weiss FU, Karger B, Aghdassi A, Lerch MM, Brinkmann B (2004) Fatal cerebro-renal oxalosis after appendectomy. Int J Legal Med 118:98–100PubMedGoogle Scholar
  183. Pfordt J, Magerl H, Vock R (1987) Fatal intoxications with propoxur. Z Rechtsmed 98:43–48PubMedGoogle Scholar
  184. Pieroni M, Cavallaro R, Chimenti C, Smeraldi E, Frustaci A (2004) Clozapine-induced hypersensitivity myocarditis. Chest 126:1703–1705PubMedGoogle Scholar
  185. Pietsch J, Schulz K, Schmidt U, Andresen H, Schwarze B, Dreßler J (2007) A comparative study of five fatal cases of Taxus poisoning. Int J Legal Med 121:417–422PubMedGoogle Scholar
  186. Pikula B, Plamenac P, Ćurčić B, Nikulin A (1973) Myocarditis caused by primary oxalosis in a 4-year-old child. Virch Arch A Path Anat 358:99–103Google Scholar
  187. Plewig G, Jansen T (1998) Acneiform dermatoses. Dermatology 196:102–107PubMedGoogle Scholar
  188. Pomara C, Fiore C, D’Errico S, Riezzo I, Fineschi V (2008) Calcium oxalate crystals in acute ethylene glycol poisoning: a confocal laser scanning microscope study in a fatal case. Clin Toxicol 46:322–324Google Scholar
  189. Prat S, Hoizey G, Lefrancq T, Saint-Martin P (2015) An unusual case of strychnine poisoning. J Forensic Sci 60:816817Google Scholar
  190. Pribilla O (1966) Tödliche Vergiftungen mit Salzen der Kieselfluorwasserstoffsäure. In: Gerchow J (ed) An den Grenzen von Medizin und Recht. Enke, StuttgartGoogle Scholar
  191. Pullela R, Young L, Gallagher B, Avis S, Randell EW (2008) A case of fatal aconitine poisoning by monkshood ingestion. J Forensic Sci 53:491–494PubMedGoogle Scholar
  192. Pumphrey RS, Roberts IS (2000) Postmortem findings after fatal anaphylactic reactions. J Clin Pathol 53:273–276PubMedPubMedCentralGoogle Scholar
  193. Razminia M, Salem Y, Sivasubramaniam D, Shah N, Khosla S (2006) Clozapine induced myocarditis. Early recognition improves clinical outcome. Am J Ther 13:274–276PubMedGoogle Scholar
  194. Reye RDK, Morgan G, Baral J (1963) Encephalopathy and fatty degeneration of the viscera. A disease entity in childhood. Lancet 2:749–752PubMedGoogle Scholar
  195. Riße M, Türker T, Weiler G (1998) Postmortale Differentialdiagnose und forensische Relevanz kutaner Blasenbildungen. Rechtsmedizin 8:141–146Google Scholar
  196. Ritter C, Weiler G, Adebahr G (1985) Histomorphological lung results in cases of long-term artificial respiration with special consideration of use of pure oxygen. Z Rechtsmed 94:41–49PubMedPubMedCentralGoogle Scholar
  197. Roll P, Klintschar M (1999) Two cases of poisoning resulting from accidental ingestion of Meadow Saffron (Colchicum autumnale). Proceedings of the international association of forensic sciences 15th triennial meeting, The International Association of Forensic Sciences, Los Angeles, 22–28 Aug 1999Google Scholar
  198. Rubin E (1980) Iatrogenic hepatic injury. Hum Pathol 11:312–331PubMedGoogle Scholar
  199. Safrai A (2007) Morphological changes in toxic hepatitis. Forensic Sci Int/Abstracts 169S:2Google Scholar
  200. Saleki S, Ardalan FA, Javidan-Nejad A (2007) Liver histopathology of fatal phosphine poisoning. Forensic Sci Int 16:190–193Google Scholar
  201. Salomone L, Scorsone A (1961) Myocardinfarkt als Folge einer Blausäurevergiftung. Folia Med Napoli 44:609. (zitiert nach: Janssen 1977)Google Scholar
  202. Sannohe S, Makino Y, Kita T, Kuroda N, Shinozuka T (2002) Colchicine poisoning resulting from accidental ingestion of meadow saffron (Colchicum autumnale). J Forensic Sci 47:1391–1396PubMedGoogle Scholar
  203. Schonberg LA (1982) Peliosis hepatis and oral contraceptives. A case report. J Reprod Med 27:753–756PubMedGoogle Scholar
  204. Schwartz LB, Metcalfe DD, Miller JS, Earl H, Sullivan T (1987) Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med 316:1622–1626PubMedGoogle Scholar
  205. Shaohua Z, Ananda S, Ruxia Y, Liang R, Xiaorui C, Liang L (2010) Fatal renal failure due to Chinese herb “GuanMu Tong” (Aristolochia manshuriensis): autopsy findings and review of the literature. Forensic Sci Int 1999:e5–e7Google Scholar
  206. Shepherd GM (2003) Hypersensitivity reactions to drugs: evaluation and management. Mt Sinai J Med 70:113–125PubMedGoogle Scholar
  207. Sinn LE, Porterfield JF (1991) Fatal taxine poisoning from yew leaf ingestion. J Forensic Sci 36:599–601PubMedGoogle Scholar
  208. Socas L, Zumbado M, Perez-Luzardo O et al (2005) Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and review of the literature. Br J Sports Med 39:27–31Google Scholar
  209. Stanworth D, Hunt NCA, Flanagan RJ (2012) Clozapine – a dangerous drug in a clozapine-naïve subject. Forensic Sci Int 214:e23–e25PubMedGoogle Scholar
  210. Steinwachs A, Grohmann R, Pedrosa F, Rüther E, Schwerdtner I (1999) Two cases of olanzapine-induced reversible neutropenia. Pharmacopsychiatry 32:154–156PubMedGoogle Scholar
  211. Stemmermann GN, Hayashi T (1971) Colchicine intoxication: a reappraisal of its pathology based on a study of three fatal cases. Hum Pathol 2:321–332PubMedGoogle Scholar
  212. Summer HW, Tedesco FJ (1975) Rectal biopsy in clindamycin-associated colitis. Arch Pathol 99:237–241Google Scholar
  213. Symmers WSC (1962) The occurrence of angiitis and other generalized diseases of connective tissues as a consequence of the administration of drugs. Proc R Soc Med 55:20–28PubMedCentralGoogle Scholar
  214. Takahashi S, Kanetake J, Kanawaku Y, Funayama M (2008) Brain death with calcium oxalate deposition in the kidney: clue to diagnosis of ethylene glycol poisoning. Legal Med 10:43–45PubMedGoogle Scholar
  215. Teare RD (1976) Poisoning by paraquat. Med Sci Law 16:9–12PubMedGoogle Scholar
  216. Teschke R (2001) Toxische Leberschäden durch Arzneimittel. Dtsch Ärztebl 40:B-2220–B-2225Google Scholar
  217. Thaler H (1987) Leberkrankheiten, 2nd edn. Springer, Heidelberg, New York, TokioGoogle Scholar
  218. Thiblin I, Lindquist O, Rajs J (2000) Cause and manner of death among users of anabolic androgenic steroids. J Forensic Sci 45:16–23PubMedGoogle Scholar
  219. Thiblin I, Mobini-Far H, Frisk M (2009) Sudden unexpected death in a female athlete, with a possible connection to the use of anabolic androgenic steroids (AAS) and ephedrine. Forensic Sci Int 184:e7–e11PubMedGoogle Scholar
  220. Thierauf A, Gnann H, Bohnert M, Vennemann B, Auwärter V, Weinmann W (2009) Suicidal poisoning with mercaptodimethur – morphological findings and toxicological analysis. Int J Legal Med 123:327–331PubMedGoogle Scholar
  221. Thomas DW, Edwards JB, Gilligan JE, Lawrence JR, Edwards RG (1972) Complications following intravenous administration of solutions containing xylitol. Med J Aust 1:1238–1246PubMedGoogle Scholar
  222. Thurner J (1970) Iatrogene pathologie. Urban & Schwarzenberg, MünchenGoogle Scholar
  223. Timm F (1958) Zur Histochemie der Schwermetalle. Das Sulfidsilberverfahren. Dtsch Z ges gerichtl Med 46:706Google Scholar
  224. Timm F (1961) Der histochemische Nachweis der Sublimatvergiftung. Beitr Gerichtl Med 21:195Google Scholar
  225. Timm F (1962) Zur Histochemie der chronischen Quecksilbervergiftung. Beitr Gerichtl Med 22:321Google Scholar
  226. Tischer KH, Heyny von Haussen R, Mall G, Doenecke P (2003) Koronarthrombosen und –ektasien nach langjähriger Einnahme von anabolen Steroiden. Z Kardiol 92:326–331PubMedGoogle Scholar
  227. Tóth AR, Varga T (2009) Myocardium and striated muscle damage caused by licit and illicit drugs. Legal Med 11:S484–S487PubMedGoogle Scholar
  228. Totović V (1964) Elektronenmikroskopische Befunde in der Niere bei chronischer Bleivergiftung der Ratte. Verh Dtsch Ges Path 339:193Google Scholar
  229. Trani N, Bonetti LR, Gualandri G, Barbolini G (2008) Immediate anaphylactic death following antibiotics injection: splenic eosinophilia easily revealed by pagoda red stain. Forensic Sci Int 181:21–25Google Scholar
  230. Tsokos M, Erbersdobler A (2005) Pathology of peliosis. Forensic Sci Int 149:25–33Google Scholar
  231. Tsokos M, Püschel K (2004) Isolated peliosis of the spleen: report of 2 autopsy cases. Am J Forensic Med Pathol 25:251–254PubMedGoogle Scholar
  232. Tsokos M, Sperhake J (2002) Coma blisters in a case of fatal theophylline intoxication. Am J Forensic Med Pathol 23:292–294PubMedGoogle Scholar
  233. Türk EE, Sperhake JP, Tsokos M (2002) Pseudomembranous colitis with fatal outcome in a 43-year-old man. Legal Med 4:246–250PubMedGoogle Scholar
  234. Tzirogiannis KN, Papadimas GK, Kondyli VG, Kourentzi KT, Demonakou MD, Kyriakou LG, Mykoniatis MG, Hereti RI, Panoutsopoulos GI (2006) Peliosis hepatis: microscopic and macroscopic type, time pattern, and correlation with liver cell apoptosis in a model of toxic liver injury. Dig Dis Sci 51:1998–2006PubMedGoogle Scholar
  235. Ulrich W, Schwarz HP, Aiginger P, Grabner G, Kumpan W, Seidl G (1982) Pulmonale hyaline Membranen nach Zytostatikatherapie. For Pathol 3:195–197Google Scholar
  236. Unuma K, Harada K, Nakajima M, Eguchi H, Tsushima K, Ito T, Shintani-Ishida K, Kojima H, Yoshida K (2010) Forensic Sci Int 194:e5–e8PubMedGoogle Scholar
  237. Valla D, Benhamou JP (1988) Drug-induced vascular and sinusoidal lesions of the liver. Baillières Clin Gastroenterol 2:481–500PubMedGoogle Scholar
  238. Van Erpecum KJ, Janssens AR, Kreuning J, Ruiter DJ, Kroon HM, Grond AJ (1988) Generalized peliosis hepatis and cirrhosis after long-term use of oral contraceptives. Am J Gastroenterol 83:572–575PubMedGoogle Scholar
  239. van Ingen G, Visser R, Peltenburg H, van der Ark AM, Voortman M (1992) Sudden unexpected death due to Taxus poisoning. A report of five cases with review of the literature. Forensic Sci Int 56:81–87PubMedGoogle Scholar
  240. Ventura F, Bonsignore A, de Stefano F, Pizzorno E, Palmiere C (2014) Fatal intrahepatic hemorrhage after nadroparin use for total hip arthroplasty. Forensic Sci Med Pathol 10:619–622PubMedGoogle Scholar
  241. Vock R (1984) Iatrogene histopathologische Befunde – eine systematische Zusammenstellung. Z Rechtsmed 92:1–25PubMedGoogle Scholar
  242. von der Hardt H, Cardesa A (1971) Die histopathologischen Frühveränderungen nach Paraquat-Intoxikation. Klin Wochenschr 49:544–550PubMedGoogle Scholar
  243. Vougiouklakis T, Mitselou A, Batistatou A, Boumba V, Charalabopoulos K (2009) First case of fatal pulmonary peliosis without any other organ involvement in a young testosterone abusing male. Forensic Sci Int 186:e13–e16PubMedGoogle Scholar
  244. Wagner-Thiessen E (1985) Das Reye-syndrom. Pathologe 6:220–223PubMedGoogle Scholar
  245. Weber W (1985) Genesis of atraumatic liver hemorrhages. Z Rechtsmed 95:145–152PubMedGoogle Scholar
  246. Wehmeier PM, Heiser P, Remschmidt H (2005) Myocarditis, pericarditis and cardiomyopathy in patients treated with clozapine. J Clin Pharm Ther 30:91–96PubMedGoogle Scholar
  247. Welder AA, Melchert RB (1993) Cardiotoxic effects of cocaine and anabolic-androgenic steroids in the athletes. J Pharmacol Toxicol Methods 29:61–68PubMedGoogle Scholar
  248. Westaby D, Ogle SJ, Paradinas FJ, Randell JB, Murray-Lyon IM (1977) Liver damage from long-term methyltestosterone. Lancet 2:262–263PubMedGoogle Scholar
  249. Wilbert L, Creutzfeld W (1967) Wiederholter Ikterus mit tödlicher Lebernekrose nach zweimaliger Halothan-Narkose. Dtsch Med Wochenschr 13:597–600Google Scholar
  250. Wittstock G (1983) Focal nodular hyperplasia of the liver. Zbl Allg Pathol 127:135–143Google Scholar
  251. Wölkart N, Soos E, Rankl W (1954) Zur Klinik und Pathologie der Knollenblätterpilzvergiftung. Wien klinische Wochenschr Sonderabdruck 16:273–276Google Scholar
  252. Wollersen H, Erdmann F, Risse M, Dettmeyer R (2009a) Accidental fatal ingestion of colchicine-containing leaves – toxicological and histological findings. Legal Med 11:S498–S499PubMedGoogle Scholar
  253. Wollersen H, Erdmann F, Risse M, Dettmeyer R (2009b) Oxalate-crystals in different tissues following intoxication with ethylene glycol: three case reports. Legal Med 11:S488–S490PubMedGoogle Scholar
  254. Yamada M, Nakagawa M, Haritani M, Kobayashi M, Furuoka H, Matsui T (1998) Histopathological study of experimental acute poisoning of cattle by autumn crocus (Colchicum autumnale L.) J Vet Med Sci 60:949–952PubMedGoogle Scholar
  255. Yamazaki A, Iranami H, Nishikawa K (2013) Severe colchicine intoxication after self-administration of colchicine concomitantly with loxoprofen. J Anesth 27:483–484PubMedGoogle Scholar
  256. Yilmaz R, Yilmaz E, Ozdemir V, Can M, Pakis I, Piskin IE, Dokgoz H, Ozer E, Numanoglu KV (2015) An evaluation of childhood deaths in Turkey due to yellow phosphorus in firecrackers. J Forensic Sci 60:648–652PubMedGoogle Scholar
  257. Yunginger JW, Nelson DR, Squillace DL, Jones RT, Holley KE, Hyma BA et al (1991) Laboratory investigations of deaths due to anaphylaxis. J Forensic Sci 36:857–865PubMedGoogle Scholar
  258. Zak F (1959) Peliosis hepatis. Am J Pathol 26:1–15Google Scholar
  259. Zhang M, Tavora F, Zhang Y, Ripple M, Fowler D, Zhao Z, Burke A (2013) The role of focal myocardial inflammation in sudden unexpected cardiac and non-cardiac deaths – a clinicopathological study. Int J Legal Med 127:131–138PubMedGoogle Scholar
  260. Zimmerman HJ (1978) Drug-induced liver disease. Drugs 16:25–45PubMedGoogle Scholar
  261. Zimmerman HJ, Ishak KG (1982) Valproate induced hepatic injury. Analysis of 23 fatal cases. Hepatology 2:591–597PubMedGoogle Scholar
  262. Zimmerman HJ, Ishak KG (2002) Hepatic injury due to drugs and toxins. In: MacSween RNM, Burt AD, Portmann BC, Ishak KG, Scheuer PJ, Anthony PP (eds) Pathology of the liver, 4th edn. Churchill Livingstone, London, pp 621–709Google Scholar
  263. Zollinger HU (1953) Durch chronische Bleivergiftung erzeugte Nierenadenome und –carcinome bei Ratten und ihre Beziehungen zu den entsprechenden Neubildungen des Menschen. Virchows Arch Path Anat 323:694Google Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Reinhard B. Dettmeyer
    • 1
  1. 1.University Hospital Giessen Institute of Forensic MedicineGiessenGermany

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