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Channelopathies in Heart Disease pp 421–437Cite as

Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Personalized Therapeutic Strategies?

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Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 6))

Abstract

Human induced pluripotent stem cells, which can be generated from somatic cells of healthy or diseased subjects, hold a great potential for research in the field of cardiac channelopathies. This review discusses how these cells can be used for disease modelling, as a safety pharmacology platform to assess the proarrhythmic potential of drug candidates, and for developing personalized therapeutic strategies by predicting individual drug responses as well as providing a system for patient-specific cardiac gene expression profiling and in vitro testing of patient-specific therapies.

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Authors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

    Daniel Sinnecker & Alessandra Moretti

  2. DZHK (German Centre for Cardiovascular Research)—Partner Site Munich Heart Alliance, Munich, Germany

    Daniel Sinnecker & Alessandra Moretti

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  2. Alessandra Moretti
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Correspondence to Daniel Sinnecker .

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Editors and Affiliations

  1. Department of Cardiology and HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Heidelberg, Germany

    Dierk Thomas

  2. Dept. of Clinical & Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Carol Ann Remme

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The authors have been supported by the German Research Foundation (Mo 2217/1–1, Si 1747/1–1, Research Unit 923), the German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, and the Else Kröner-Fresenius Stiftung.

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The authors declared that they have no conflict of interest.

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Sinnecker, D., Moretti, A. (2018). Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Personalized Therapeutic Strategies?. In: Thomas, D., Remme, C. (eds) Channelopathies in Heart Disease . Cardiac and Vascular Biology, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-77812-9_16

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