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Pain

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Abstract

Cancer survivors with pain represent a distinct group of patients. They are likely to be under-assessed for pain and may experience pain syndromes and other symptoms related to their cancer or treatment. The prevalence of pain in cancer survivors is elevated compared to the general population. Approximately one third of pain complaints are ascribed by patients to their treatment, although pain may persist for years. Pain from comorbid conditions, such as musculoskeletal pain, is also prevalent. This chapter describes new insights about the etiologies and manifestations of cancer-related pain and distinct symptoms in different groups of cancer survivors. We also provide recommendations for a biopsychosocial approach to pain assessment and management. Additional research, both basic and clinical, on cancer survivor groups is needed.

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References

  1. Levy MH, Chwistek M, Mehta RS. Management of chronic pain in cancer survivors. Cancer J. 2008;14(6):401–9.

    Article  PubMed  Google Scholar 

  2. Glare PA, Davies PS, Finlay E, Gulati A, Lemanne D, Moryl N, et al. Pain in cancer survivors. J Clin Oncol. 2014;32(16):1739–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. van den Beuken-van Everdingen MH, Hochstenbach LM, Joosten EA, Tjan-Heijnen VC, Janssen DJ. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manag. 2016;51(6):1070–90.

    Article  Google Scholar 

  4. Huang IC, Hudson MM, Robison LL, Krull KR. Differential impact of symptom prevalence and chronic conditions on quality of life in cancer survivors and non-cancer individuals: a population study. Cancer Epidemiol Biomark Prev. 2017;26(7):1124–32.

    Article  Google Scholar 

  5. Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, et al. Health status of adult long term survivors of childhood cancer. A report from the Childhood Cancer Survivor Study. JAMA. 2003;290(12):1583–92.

    Article  CAS  PubMed  Google Scholar 

  6. D'Agostino NM, Edelstein K, Zhang N, Recklitis CJ, Brinkman TM, Srivastava D, et al. Comorbid symptoms of emotional distress in adult survivors of childhood cancer. Cancer. 2016;122(20):3215–24.

    Article  PubMed  Google Scholar 

  7. Deimling GT, Sterns S, Bowman KF, Kahana B. The health of older-adult, long-term cancer survivors. Cancer Nurs. 2005;28:415–24.

    Article  PubMed  Google Scholar 

  8. Keating NL, Norredam M, Landrum MB, Huskamp HA, Meara E. Physical and mental health status of older long-term cancer survivors. J Am Geriatric Soc. 2005;53(12):2145–52.

    Article  Google Scholar 

  9. Shi Q, Smith TG, Michonski JD, Stein KD, Kaw C, Cleeland CS. Symptom burden in cancer survivors 1 year after diagnosis: a report from the American Cancer Society’s Studies of Cancer Survivors. Cancer. 2011;117(12):2779–90.

    Article  PubMed  Google Scholar 

  10. Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M. It’s not over when it’s over: long-term symptoms in cancer survivors – a systematic review. Int J Psychiatry Med. 2010;40(2):163–81.

    Article  PubMed  Google Scholar 

  11. Lu Q, Krull KR, Leisenring W, Owen JE, Kawashima T, Tsao JC, et al. Pain in long-term adult survivors of childhood cancers and their siblings: a report from the Childhood Cancer Survivor Study. Pain. 2011;152(11):2616–24.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Green CR, Hart-Johnson T, Loeffler DR. Cancer related chronic pain. Examining quality of life in diverse survivors. Cancer. 2011;117(9):1994–2003.

    Article  PubMed  Google Scholar 

  13. Peretti-Watel P, Bendiane MK, Spica L, Rey D. Pain narratives in breast cancer survivors. Pain Res Treatment. 2012;2012:153060.

    Article  Google Scholar 

  14. Lowery AE, Krebs P, Coups EJ, Feinstein MB, Burkhalter JE, Park BJ, et al. Impact of symptom burden in post-surgical non-small cell lung cancer survivors. Support Care Cancer. 2014;22(1):173–80.

    Article  PubMed  Google Scholar 

  15. Tevaarwerk AJ, Lee JW, Sesto ME, Buhr KA, Cleeland CS, Manola J, et al. Employment outcomes among survivors of common cancers: the Symptom Outcomes and Practice Patterns (SOAPP) study. J Cancer Surviv. 2013;7(2):191–202.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Wang HL, Kroenke K, Wu J, Tu W, Theobald D, Rawl SM. Cancer-related pain and disability: a longitudinal study. J Pain Symptom Manag. 2011;42(6):813–21.

    Article  Google Scholar 

  17. Kenzik K, Pisu M, Johns SA, Baker T, Oster RA, Kvale E, et al. Unresolved pain interference among colorectal cancer survivors: implications for patient care and outcomes. Pain Med. 2015;16(7):1410–25.

    Article  PubMed  Google Scholar 

  18. Ossipov MH, Morimura K, Porreca F. Descending pain modulation and the chronification of pain. Curr Opin Pall Supp Care. 2014;8(2):143–51.

    Google Scholar 

  19. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, et al. Redefinition of neuropathic pain and a grading system for clinical use: consensus statement on clinical and research diagnostic criteria. Neurology. 2008;70(18):1630–5.

    Article  CAS  PubMed  Google Scholar 

  20. Bennett MI, Rayment C, Hjermstad M, Aass N, Caraceni A, Kaasa S. Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review. Pain. 2012;153(2):359–65.

    Article  PubMed  Google Scholar 

  21. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81(9):646–56.

    PubMed  PubMed Central  Google Scholar 

  22. Mantyh PW. The neurobiology of skeletal pain. Eur J Neurosci. 2014;39(3):508–19.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Chartier SR, Thompson ML, Longo G, Fealk MN, Majuta LA, Mantyh PW. Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain. Pain. 2014;155(11):2323–36.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Cervero F, Laird JM. Visceral pain. Lancet. 1999;353(9170):2145–8.

    Article  CAS  PubMed  Google Scholar 

  25. Woolf C, Bromley L. Pre-emptive analgesia by opioids. In: Stein C, editor. Opioids in pain control. Basic and clinical aspects. New York: Cambridge University Press; 1999. p. 212–33.

    Google Scholar 

  26. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367(9522):1618–25.

    Article  PubMed  Google Scholar 

  27. Macrae WA. Chronic post surgical pain. Ten years on. Br J. Anaesthesia. 2008;101(1):77–86.

    Article  CAS  Google Scholar 

  28. Haroutiunian S, Nikolajsen L, Finnerup NB, Jensen TS. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain. 2013;154(1):95–102.

    Article  PubMed  Google Scholar 

  29. Furtado S, Grimer RJ, Cool P, Murray SA, Briggs T, Fulton J, et al. Physical functioning, pain and quality of life after amputation for musculoskeletal tumours: a national survey. Bone Joint J. 2015;97-B(9):1284–90.

    Article  CAS  PubMed  Google Scholar 

  30. Merskey H, Bogduk N. Classification of chronic pain. Seattle: IASP Press; 1994. p. 40.

    Google Scholar 

  31. Dorpat TL. Phantom sensations of internal organs. Compr Psychiatry. 1971;12(1):27–35.

    Article  CAS  PubMed  Google Scholar 

  32. Lubbers EJ. Phantom sensations after excision of the rectum. Dis Colon Rectum. 1984;27(12):777–8.

    Article  CAS  PubMed  Google Scholar 

  33. Ovesen P, Kroner K, Ornsholt J, Bach K. Phantom-related phenomena after rectal amputation: prevalence and clinical characteristics. Pain. 1991;44(3):289–91.

    Article  CAS  PubMed  Google Scholar 

  34. Kroner K, Krebs B, Skov J, Jorgensen HS. Immediate and long-term phantom breast syndrome after mastectomy: incidence, clinical characteristics and relationship to pre-mastectomy breast pain. Pain. 1989;36(3):327–44.

    Article  CAS  PubMed  Google Scholar 

  35. Whyte AS, Niven CA. Variation in phantom limb pain: results of a diary study. J Pain Symptom Manag. 2001;22(5):947–53.

    Article  CAS  Google Scholar 

  36. Luo Y, Anderson TA. Phantom limb pain: a review. Int Anesthesiol Clin. 2016;54(2):121–39.

    Article  PubMed  Google Scholar 

  37. Sugarbaker PH, Weiss CM, Davidson DD, Roth YF. Increasing phantom limb pain as a symptom of cancer recurrence. Cancer. 1984;54(2):373–5.

    Article  CAS  PubMed  Google Scholar 

  38. Elliott K, Foley KM. Neurologic pain syndromes in patients with cancer. Neurol Clin. 1989;7(2):333–60.

    Article  CAS  PubMed  Google Scholar 

  39. Chang VT, Tunkel RS, Pattillo BA, Lachmann EA. Increased phantom limb pain as an initial symptom of spinal neoplasia. J Pain Symptom Manag. 1997;13(6):362–4.

    Article  CAS  Google Scholar 

  40. Sist T, Miner M, Lema M. Characteristics of postradical neck dissection pain syndrome: a report of 25 cases. J Pain Symptom Manag. 1999;18(2):95–102.

    Article  CAS  Google Scholar 

  41. van Wilgen CP, Dijkstra PU, van der Laan BF, Plukker JT, Roodenburg JL. Morbidity of the neck after head and neck cancer therapy. Head Neck. 2004;26(9):785–91.

    Article  PubMed  Google Scholar 

  42. Merskey H, Bogduk N. Classification of chronic pain. 2nd ed. Seattle, WA: IASP Press. p. 142.

    Google Scholar 

  43. Carpenter JS, Sloan P, Andrykowski MA, McGrath P, Sloan D, Rexford T, et al. Risk factors for pain after mastectomy/lumpectomy. Cancer Pract. 1999;7(2):66–70.

    Article  CAS  PubMed  Google Scholar 

  44. Wisotzky E, Hanrahan N, Lione TP, Maltser S. Deconstructing postmastectomy syndrome. Implications for physiatric management. Phys Med Rehab Clinic N Am. 2017;28(2):153–69.

    Article  Google Scholar 

  45. Stubblefield MD, Custodio CM. Upper-extremity pain disorders in breast cancer. Arch Phys Med Rehabil. 2006;87(3 Suppl 1):S96–9.

    Article  PubMed  Google Scholar 

  46. Carpenter JS, Andrykowski MA, Sloan P, Cunningham L, Cordova MJ, Cordova MJ, et al. Postmastectomy/ postlumpectomy pain in breast cancer survivors. J Clin Epidemiol. 1998;51(12):1285–92.

    Article  CAS  PubMed  Google Scholar 

  47. Alves Nogueira Fabro E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, deSouza Abrahão K, da Costa Leite Ferreira MG, et al. Post-mastectomy pain syndrome: incidence and risks. Breast. 2012;21(3):321–5.

    Article  PubMed  Google Scholar 

  48. Andersen KG, Duriaud HM, Jensen HE, Kroman N, Kehlet H. Predictive factors for the development of persistent pain after breast cancer surgery. Pain. 2015;156(12):2413–22.

    Article  PubMed  Google Scholar 

  49. Torres Lacomba M, Mayoral del Moral O, Coperias Zazo JL, Gerwin RD, Goñí AZ. Incidence of myofascial pain syndrome in breast cancer surgery: a prospective study. Clin J Pain. 2010;26(4):320–5.

    Article  PubMed  Google Scholar 

  50. Schou Bredal I, Smeby NA, Ottesen S, Warncke T, Schlichting E. Chronic pain in breast cancer survivors: comparison of psychosocial, surgical, and medical characteristics between survivors with and without pain. J Pain Symptom Manag. 2014;48(5):852–62.

    Article  Google Scholar 

  51. Peuckmann V, Ekholm O, Rasmussen NK, Groenvold M, Christiansen P, Møller S, et al. Chronic pain and other sequelae in long-term breast cancer survivors: nationwide survey in Denmark. Eur J Pain. 2009;13(5):478–85.

    Article  CAS  PubMed  Google Scholar 

  52. MacDonald L, Bruce J, Scot NW, Smith WC, Chambers WA. Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome. Br J Cancer. 2005;92(2):225–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Hille-Betz U, Vaske B, Bremer M, Soergel P, Kundu S, Klapdor R, et al. Late radiation side effects, cosmetic outcomes and pain in breast cancer patients after breast-conserving surgery and three-dimensional conformal radiotherapy: risk-modifying factors. Strahlenther Onkol. 2016;192(1):8–16.

    Article  PubMed  Google Scholar 

  54. Wang L, Guyatt GH, Kennedy SA, Romerosa B, Kwon HY, Kaushal A, et al. Predictors of persistent pain after breast cancer surgery: a systematic review and meta-analysis of observational studies. CMAJ. 2016;188(14):E352–61.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Merskey H, Bogduk N. Classification of chronic pain. 2nd ed. Seattle: IASP Press. p. 143.

    Google Scholar 

  56. Rogers ML, Duffy JP. Surgical aspects of chronic post-thoracotomy pain. Eur J Cardiothorac Surg. 2000;18(6):711–6.

    Article  CAS  PubMed  Google Scholar 

  57. Gotoda Y, Kambara N, Sakai T, Kishi Y, Kodama K, Koyama T. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur J Pain. 2001;5(1):89–96.

    Article  CAS  PubMed  Google Scholar 

  58. Petrek JA, Heelan MC. Incidence of breast carcinoma-related lymphedema. Cancer. 1998;83(12 Suppl American):2776–81.

    Article  CAS  PubMed  Google Scholar 

  59. Petrek JA, Senie RT, Peters M, et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer. 2001;92(6):1368–77.

    Article  CAS  PubMed  Google Scholar 

  60. Bosompra K, Ashikaga T, O’Brien PJ, Nelson L, Skelly J. Swelling numbness, pain and their relationship to arm function among breast cancer survivors: a disablement process model perspective. Breast J. 2002;8(6):338–48.

    Article  PubMed  Google Scholar 

  61. Newman ML, Brennan M, Passik S. Lymphedema complicated by pain and psychological distress: a case with complex treatment needs. J Pain Symptom Manag. 1996;12(6):376–9.

    Article  CAS  Google Scholar 

  62. McWayne J, Heiney SP. Psychologic and social sequelae of secondary lymphedema: a review. Cancer. 2005;104(3):457–66.

    Article  PubMed  Google Scholar 

  63. Ryan M, Stainton MC, Jaconelli C, et al. The experience of lower limb lymphedema for women after treatment for gynecologic cancer. Oncol Nurs Forum. 2003;30(3):417–23.

    Article  PubMed  Google Scholar 

  64. Beesley V, Janda M, Eakin E, Obermair A, Battistutta D. Lymphedema after gynecological cancer treatment : prevalence, correlates, and supportive care needs. Cancer. 2007;109(12):2607–14.

    Article  PubMed  Google Scholar 

  65. Stubblefield MD. Radiation fibrosis syndrome: neuromuscular and musculoskeletal complications in cancer survivors. PM R. 2011;3(11):1041–54.

    Article  PubMed  Google Scholar 

  66. Yamada K, Takeshima H, Sakurama T, Kuratsu J. Secondary cervical dystonia following stereotactic radiosurgery in a patient with thalamic glioma. Surg Neurol. 2007;68(6):665–70.

    Article  PubMed  Google Scholar 

  67. Kutvonen O, Dastidar P, Nurmikko T. Pain in spasmodic torticollis. Pain. 1997;69(3):279–86.

    Article  CAS  PubMed  Google Scholar 

  68. Kori SH, Foley KM, Posner JB. Brachial plexus lesions in patients with cancer: 100 cases. Neurology. 1981;31(1):45–50.

    Article  CAS  PubMed  Google Scholar 

  69. Johansson S, Svensson H, Denekamp J. Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients. Int J Radiat Oncol Biol Phys. 2002;52(5):1207–19.

    Article  PubMed  Google Scholar 

  70. Bajrovic A, Rades D, Fehlauer F, Tribius S, Hoeller U, Rudat V, et al. Is there a life-long risk of brachial plexopathy after radiotherapy of supraclavicular lymph nodes in breast cancer patients? Radiother Oncol. 2004;71(3):297–301.

    Article  PubMed  Google Scholar 

  71. Harper CM Jr, Thomas JE, Cascino TL, Litchy WJ. Distinction between neoplastic and radiation-induced brachial plexopathy, with emphasis on the role of EMG. Neurology. 1989;39(4):502–6.

    Article  PubMed  Google Scholar 

  72. Expert Panel on Neurologic Imaging, Bykowski J, Aulino JM, Berger KL, Cassidy RC, Choudhri AF, et al. ACR appropriateness criteria(®) plexopathy. J Am Coll Radiol. 2017;14(5S):S225–33.

    Google Scholar 

  73. Muls AC. Acta Oncologica Lecture. Gastrointestinal consequences of cancer treatment and the wider context: a bad gut feeling. Acta Oncol. 2014;53(3):297–306.

    Article  PubMed  Google Scholar 

  74. Gami B, Harrington K, Blake P, Dearnaley D, Tait D, Davies J, et al. How patients manage gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther. 2003;18(10):987–94.

    Article  CAS  PubMed  Google Scholar 

  75. Andreyev HJ, Benton BE, Lalji A, Norton C, Mohammed K, Gage H, et al. Algorithm-based management of patients with gastrointestinal symptoms in patients after pelvic radiation treatment (ORBIT): a randomised controlled trial. Lancet. 2013;382(9910):2084–92.

    Article  PubMed  Google Scholar 

  76. Lind H, Waldenstrom A-C, Dunberger G, al-Abany M, Alevronta E, Johansson K-A, et al. Late symptoms in long term gynaecological cancer patients after radiation therapy: a population based cohort study. Br J Cancer. 2011;105:737–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Bazire L, Xu H, Foy JP, Amessis M, Malhaire C, Cao K, et al. Pelvic insufficiency fracture (PIF) incidence in patients treated with intensity-modulated radiation therapy (IMRT) for gynaecological or anal cancer: single-institution experience and review of the literature. Br J Radiol. 2017;90(1073):20160885.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Iğdem S, Alço G, Ercan T, Barlan M, Ganiyusufoğlu K, Unalan B, et al. Insufficiency fractures after pelvic radiotherapy in patients with prostate cancer. Int J Radiat Oncol Biol Phys. 2010;77(3):818–23.

    Article  PubMed  Google Scholar 

  79. Herman MP, Kopetz S, Bhosale PR, Eng C, Skibber JM, Rodriguez-Bigas MA, et al. Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: incidence, risk factors, and clinical course. Int J Radiat Oncol Biol Phys. 2009;74(3):818–23.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Osler P, Bredella MA, Hess KA, Janssen SJ, Park CJ, Chen YL, et al. Sacral insufficiency fractures are common after high-dose radiation for sacral chordomas treated with or without surgery. Clin Orthop Relat Res. 2016;474(3):766–72.

    Article  PubMed  Google Scholar 

  81. Higham CE, Faithfull S. Bone health and pelvic radiotherapy. Clin Oncol. 2015;27(1):668–78.

    Article  CAS  Google Scholar 

  82. Schmeler KM, Jhingran A, Iyer RB, Sun CC, Eifel PJ, Soliman PT, et al. Pelvic fractures after radiotherapy for cervical cancer: implications for survivors. Cancer. 2010;116(3):625–30.

    Article  PubMed  Google Scholar 

  83. Salavati A, Shah V, Wang ZJ, Yeh BM, Costouros NG, Coakley FV. F-18 FDG PET/CT findings in postradiation pelvic insufficiency fracture. Clin Imaging. 2011;35(2):139–42.

    Article  PubMed  Google Scholar 

  84. Dropcho EJ. Neurotoxicity of radiation therapy. Neurol Clin. 2010;28(1):217–34.

    Article  PubMed  Google Scholar 

  85. Thomas JE, Cascino TL, Earle JD. Differential diagnosis between radiation and tumor plexopathy of the pelvis. Neurology. 1985;35(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  86. Jaeckle KA, Young DF, Foley KM. The natural history of lumbosacral plexopathy in cancer. Neurology. 1985;35(1):8–15.

    Article  CAS  PubMed  Google Scholar 

  87. Phillips DJ, Njoku IU, Brown KD, Selesnick SH. Radiation-induced necrosis of the temporal bone: diagnosis and management. Otol Neurotol. 2015;36(8):1374–7.

    Article  PubMed  Google Scholar 

  88. Donovan DJ, Huynh TV, Purdom EB, Johnson RE, Sniezek JC. Osteoradionecrosis of the cervical spine resulting from radiotherapy for primary head and neck malignancies: operative and nonoperative management. Case report. J Neurosurg Spine. 2005;3(2):159–64.

    Article  PubMed  Google Scholar 

  89. Feltl D, Vosmik M, Jirásek M, Stáhalová V, Kubes J. Symptomatic osteoradionecrosis of pelvic bones in patients with gynecological malignancies-result of a long-term follow-up. Int J Gynecol Cancer. 2006;16(2):478–83.

    Article  CAS  PubMed  Google Scholar 

  90. Peterson DE, Doerr W, Hovan A, Pinto A, Saunders D, Elting LS, et al. Osteoradionecrosis in cancer patients: the evidence base for treatment-dependent frequency, current management strategies, and future studies. Support Care Cancer. 2010;18(8):1089–98.

    Article  PubMed  Google Scholar 

  91. Mols F, Beijers T, Lemmens V, van den Hurk CJ, Vreugdenhil G, van de Poll-Franse LV. Chemotherapy-induced neuropathy and its association with quality of life among 2- to 11-year colorectal cancer survivors: results from the population-based PROFILES registry. J Clin Oncol. 2013;31(21):2699–707.

    Article  PubMed  Google Scholar 

  92. Kerckhove N, Collin A, Condé S, Chaleteix C, Pezet D, Balayssac D. Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol. 2017;8:86.

    Google Scholar 

  93. Tofthagen C, Overcash J, Kip K. Falls in persons with chemotherapy-induced peripheral neuropathy. Support Care Cancer. 2012;20(3):583–9.

    Article  PubMed  Google Scholar 

  94. Kolb NA, Smith AG, Singleton JR, Beck SL, Stoddard GJ, Brown S, et al. The association of chemotherapy-induced peripheral neuropathy symptoms and the risk of falling. JAMA Neurol. 2016;73(7):860–6.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Starobova H, Vetter I. Pathophysiology of chemotherapy-induced peripheral neuropathy. Front Mol Neurosci. 2017;10:174.

    Google Scholar 

  96. Brown MR, Ramirez JD, Farquhar-Smith P. Pain in cancer survivors. Br J Pain. 2014;8(4):139–53.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Kerckhove N, Collin A, Conde S, Chaletelx C, Pezel D, Balayssac D. Long term effects, pathophysiological mechanisms, and risk factors of chemotherapy induced peripheral neuropathies: a comprehensive literature review. Frontiers Pharmacol. 2017.

    Google Scholar 

  98. Schneider B, Li L, Radovich M, Shen F, Miller KD, Flockhart D, et al. Genome-wide association studies for taxane-induced peripheral neuropathy in ECOG 5013 and ECOG 1191. Clin Cancer Res. 2015;21(22):5082–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Kunstrich M, Kummer S, Laws HJ, Borkhardt A, Kuhlen M. Osteonecrosis in children with acute lymphoblastic leukemia. Haematologica. 2016;101(11):1295–305.

    Article  CAS  Google Scholar 

  100. Girard P, Auquier P, Barlogis V, Contet A, Poiree M, Demeocq F, et al. Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. Haematologica. 2013;98(7):1089–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Mattano LA Jr, Sather HN, Trigg ME, Nachman JB. Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: a report from the Children’s Cancer Group. J Clin Oncol. 2000;18(18):3262–72.

    Article  PubMed  Google Scholar 

  102. Castel LD, Hartmann KE, Mayer IA, Saville BR, Alvarez J, Boomershine CS, et al. Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort. Cancer. 2013;119(13):2375–82.

    Article  CAS  PubMed  Google Scholar 

  103. Henry NL, Azzouz F, Desta Z, Li L, Nguyen AT, Lemler S, et al. Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer. J Clin Oncol. 2012;30(9):936–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Liu M, Wang L, Bongartz T, Hawse JR, Markovic SN, Schaid DJ, et al. Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Breast Cancer Res. 2012;14(2):R41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Henry NL, Skaar TC, Dantzer J, Li L, Kidwell K, Gersch C, et al. Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer. Breast Cancer Res Treat. 2013;138(3):807–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Borrie AE, Kim RB. Molecular basis of aromatase inhibitor associated arthralgia: known and potential candidate genes and associated biomarkers. Expert Opin Drug Metab Toxicol. 2017;13(2):149–56.

    Article  CAS  PubMed  Google Scholar 

  107. Lester J, Pahouja G, Andersen B, Lustberg M. Atrophic vaginitis in breast cancer survivors: a difficult survivorship issue. J Pers Med. 2015;5:50–66.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Servitja S, Martos T, Sanz MR, Garcia-Giralt N, Prrieto-Alhambra D, Garrigos L, et al. Skeletal adverse events with aromatase inhibitors in early breast cancer: evidence to data and clinical guidance. Ther Adv Med Oncol. 2015;7(5):291–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Shao YH, Moore DF, Shih W, Lin Y, Jang TL, Lu-Yao GL. Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications. BJU Int. 2013;111(5):745–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Syrjala K, Langer SL, Abrahms JR, Storer BE, Martin PJ. Late effects of hematopoietic stem cell transplantation among 10 year adult survivors compared to case matched controls. J Clin Oncol. 2005;23(27):6596–606.

    Article  PubMed  Google Scholar 

  111. Fraser CJ, Bhatia S, Ness K, Carter A, Francisco L, Arora M, et al. Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study. Blood. 2006;108(8):2867–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Epstein JB, Thariat J, Bensadoun R-J, Barasch A, Murphy BA, Kolnick L, et al. Oral complications of cancer and cancer therapy. From cancer treatment to survivorship. CA Cancer J Clin. 2012;62(6):400–22.

    Article  PubMed  Google Scholar 

  113. Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013;58(3):233–51.

    Article  PubMed  Google Scholar 

  114. Jim HS, Sutton SK, Jacobsen PB, Martin PJ, Flowers ME, Lee SJ. Risk factors for depression and fatigue among survivors of hematopoietic cell transplantation. Cancer. 2016;122(8):1290–7.

    Article  PubMed  Google Scholar 

  115. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw–2014 update. J Oral Maxillofac Surg. 2014;72(10):1938–56.

    Article  PubMed  Google Scholar 

  116. Khan F, Amatya B. Factors associated with long-term functional outcomes, psychological sequelae and quality of life in persons after primary brain tumour. J Neuro-Oncol. 2013;111(3):355–66.

    Article  Google Scholar 

  117. Husson O, Haak HR, Buffart LM, Nieuwlaat WA, Oranje WA, Mols F, et al. Health-related quality of life and disease specific symptoms in long-term thyroid cancer survivors: a study from the population-based PROFILES registry. Acta Oncol. 2013;52(2):249–58.

    Article  PubMed  Google Scholar 

  118. Bentzen AG, Balteskard L, Wanderås EH, Frykholm G, Wilsgaard T, Dahl O, et al. Impaired health-related quality of life after chemoradiotherapy for anal cancer: late effects in a national cohort of 128 survivors. Acta Oncol. 2013;52(4):736–44.

    Article  PubMed  Google Scholar 

  119. Badin S, Iqbal A, Sikder M, Chang VT. Persistent pain in anal cancer survivors. J Cancer Surviv. 2008;2(2):79–83.

    Article  PubMed  Google Scholar 

  120. Stein KD, Alcaraz KI, Kamson C, Fallon EA, Smith TG. Sociodemographic inequalities in barriers to cancer pain management: a report from the American Cancer Society’s Study of Cancer Survivors-II (SCS-II). Psychooncology. 2016;25(10):1212–21.

    Article  PubMed  Google Scholar 

  121. Xiao C, Polomano R, Bruner DW. Comparison between patient-reported and clinician-observed symptoms in oncology. Cancer Nurs. 2013;36(6):E1–E16.

    Article  PubMed  Google Scholar 

  122. Chandwani KD, Zhao F, Morrow GR, Deshields TL, Minasian LM, Manola J, et al. Lack of patient-clinician concordance in cancer patients: its relation with patient variables. J Pain Symptom Manag. 2017;53(6):988–98.

    Article  Google Scholar 

  123. Walling AM, Keating NL, Kahn KL, Dy S, Mack JW, et al. Lower patient ratings of physician communication are associated with unmet need for symptom management in patients with lung and colorectal cancer. J Oncol Pract. 2016;12(6):e654–69.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Cooley ME, Siefert ML. Assessment of multiple co-occurring cancer symptoms in the clinical setting. Semin Oncol Nurs. 2016;32(4):361–72.

    Article  PubMed  Google Scholar 

  125. Barsevick A. Defining the symptom cluster: how far have we come? Semin Oncol Nurs. 2016;32(4):334–50.

    Article  PubMed  Google Scholar 

  126. van Hecke O, Torrance N, Smith BH. Chronic pain epidemiology – where do lifestyle factors fit in? Br J Pain. 2013;7(4):209–17.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Dale R, Stacey B. Multimodal treatment of chronic pain. Med Clin North Am. 2016;100(1):55–64.

    Article  PubMed  Google Scholar 

  128. Novy DM, Aigner CJ. The biopsychosocial model in cancer pain. Curr Opin Support Palliat Care. 2014;8(2):117–23.

    Article  PubMed  Google Scholar 

  129. Cheatle MD. Biopsychosocial approach to assessing and managing patients with chronic pain. Med Clin North Am. 2016;100(1):43–53.

    Article  PubMed  Google Scholar 

  130. National Pain Strategy: A Comprehensive Population Health-Level Strategy for Pain. https://iprcc.nih.gov/sites/default/files/HHSNational_Pain_Strategy_508C.pdf. Accessed 30 Nov 2017.

  131. Kaiser U, Treede RD, Sabatowski R. Multimodal pain therapy in chronic noncancer pain-gold standard or need for further clarification? Pain. 2017;158(10):1853–9.

    Article  PubMed  Google Scholar 

  132. Dorflinger L, Kerns RD, Auerbach SM. Providers’ roles in enhancing patients’ adherence to pain self management. Transl Behav Med. 2013;3(1):39–46.

    Article  PubMed  Google Scholar 

  133. Bennett MI, Flemming K, Closs SJ. Education in cancer pain management. Curr Opin Support Palliat Care. 2011;5(1):20–4.

    Article  PubMed  Google Scholar 

  134. Butow P, Sharpe L. The impact of communication on adherence in pain management. Pain. 2013;154(Suppl 1):S101–7.

    Article  PubMed  Google Scholar 

  135. Lovell MR, Luckett T, Boyle FM, Phillips J, Agar M, Davidson PM. Patient education, coaching, and self-management for cancer pain. J Clin Oncol. 2014;32(16):1712–20.

    Article  PubMed  Google Scholar 

  136. Schreiber JA. Understanding the cancer pain experience. Curr Pain Headache Rep. 2014;18(8):440.

    Google Scholar 

  137. Economou D. Palliative care needs of cancer survivors. Semin Oncol Nurs. 2014;30(4):262–26.

    Article  PubMed  Google Scholar 

  138. Minden P. Bearing witness: to promote therapeutic effectiveness. Holist Nurs Pract. 2013;27(3):168–76.

    Article  PubMed  Google Scholar 

  139. Silver JK, Baima J, Mayer RS. Impairment-driven cancer rehabilitation: an essential component of quality care and survivorship. CA Cancer J Clin. 2013;63(5):295–317.

    Article  PubMed  Google Scholar 

  140. Syrjala KL, Jensen MP, Mendoza ME, Yi JC, Fisher HM, Keefe FJ. Psychological and behavioral approaches to cancer pain management. J Clin Oncol. 2014;32(16):1703–11.

    Article  PubMed  PubMed Central  Google Scholar 

  141. Sheinfeld Gorin S, Krebs P, Badr H, Janke EA, Jim HS, Spring B, et al. Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. J Clin Oncol. 2012;30(5):539–47.

    Article  PubMed  PubMed Central  Google Scholar 

  142. Johannsen M, Farver I, Beck N, Zachariae R. The efficacy of psychosocial intervention for pain in breast cancer patients and survivors: a systematic review and meta-analysis. Breast Cancer Res Treat. 2013;138(3):675–90.

    Article  CAS  PubMed  Google Scholar 

  143. Belfer I, Schreiber KL, Shaffer JR, Shnol H, Blaney K, Morando A, et al. Persistent postmastectomy pain in breast cancer survivors: analysis of clinical, demographic, and psychosocial factors. J Pain. 2013;14(10):1185–95.

    Article  PubMed  Google Scholar 

  144. Wachen JS, Patidar SM, Mulligan EA, Naik AD, Moye J. Cancer-related PTSD symptoms in a veteran sample: association with age, combat PTSD, and quality of life. Psychooncology. 2014;23(8):921–7.

    Article  PubMed  PubMed Central  Google Scholar 

  145. Perkins HY, Baum GP, Taylor CL, Basen-Engquist KM. Effects of treatment factors, comorbidities and health-related quality of life on self-efficacy for physical activity in cancer survivors. Psychooncology. 2009;18(4):405–11.

    Article  PubMed  Google Scholar 

  146. Liang SY, Ding SA, Wu WW, Liu CY, Lin CC. Opioid-taking self-efficacy affects the quality of life of Taiwanese patients with cancer pain. Support Care Cancer. 2015;23(7):2113–20.

    Article  PubMed  Google Scholar 

  147. Liang SY, Chao TC, Tseng LM, Tsay SL, Lin KC, Tung HH. Symptom-management self-efficacy mediates the effects of symptom distress on the quality of life among Taiwanese oncology outpatients with breast cancer. Cancer Nurs. 2016;39(1):67–73.

    PubMed  Google Scholar 

  148. Syrjala KL, Abrams JR. Hypnosis and imagery in the treatment of pain. In: Gatchel RJ, Turk DC, editors. Psychological approaches to pain management: a practitioners handbook. 1st ed. New York: The Guilford Press; 1996. p. 231–58.

    Google Scholar 

  149. Jensen MP, Patterson DR. Hypnotic approaches for chronic pain management: clinical implications of recent research findings. Am Psychol. 2014;69(2):167–77.

    Article  PubMed  PubMed Central  Google Scholar 

  150. Altilio T, Tropeano LE. Pain and symptom management. In: Christ G, Messner C, Behar L, editors. Handbook of oncology social work. Psychosocial care for people with cancer. New York: Oxford University Press; 2015. p. 239–46.

    Google Scholar 

  151. Viscuse PV, Price K, Millstine D, Bhagra A, Bauer B, Ruddy KJ. Integrative medicine in cancer survivors. Curr Opin Oncol. 2017;29(4):235–42.

    Article  PubMed  PubMed Central  Google Scholar 

  152. Lengacher CA, Reich RR, Paterson CL, Ramesar S, Park JY, Alinat C, et al. Examination of broad symptom improvement resulting from mindfulness-based stress reduction in breast cancer survivors: a randomized controlled trial. J Clin Oncol. 2016;34(24):2827–34.

    Article  PubMed  PubMed Central  Google Scholar 

  153. Poulin PA, Romanow HC, Rahbari N, Small R, Smyth CE, Hatchard T, et al. The relationship between mindfulness, pain intensity, pain catastrophizing, depression, and quality of life among cancer survivors living with chronic neuropathic pain. Support Care Cancer. 2016;24(10):4167–75.

    Article  PubMed  Google Scholar 

  154. Lu W, Rosenthal DS. Acupuncture for cancer pain and related symptoms. Curr Pain Headache Rep. 2013;17(3):321.

    Google Scholar 

  155. Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Friedman DL, et al. National Comprehensive Cancer Network. Survivorship: pain version 1.2014. J Natl Compr Cancer Netw. 2014;12(4):488–500.

    Article  CAS  Google Scholar 

  156. Paice JA, Portenoy R, Lacchetti C, Campbell T, Cheville A, Citron M, et al. Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2016;34(27):3325–45.

    Article  PubMed  Google Scholar 

  157. Peppin JF, Albrecht PJ, Argoff C, Gustorff B, Pappagallo M, Rice FL, et al. Skin matters: a review of topical treatments for chronic pain. Part two: treatments and applications. Pain Ther. 2015;4(1):33–50.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Sommer C, Cruccu G. Topical treatment of peripheral neuropathic pain: applying the evidence. J Pain Symptom Manag. 2017;53(3):614–29.

    Article  Google Scholar 

  159. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain – United States, 2016. JAMA. 2016;315(15):1624–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  160. ASCO policy statement on opioid therapy: protecting access to treatment for cancer-related pain. https://www.asco.org/sites/new-www.asco.org/files/content-files/advocacy-and-policy/documents/2016-ASCO-Policy-Statement-Opioid-Therapy.pdf. Accessed 1 Nov 2017.

  161. Sutradhar R, Lokku A, Barbera L. Cancer survivorship and opioid prescribing rates: a population-based matched cohort study among individuals with and without a history of cancer. Cancer. 2017;123(21):4286–93.

    Article  PubMed  Google Scholar 

  162. Portenoy RK, Ahmed E. Principles of opioid use in cancer pain. J Clin Oncol. 2014;32:1662–70.

    Article  CAS  PubMed  Google Scholar 

  163. Kramer JL. Medical marijuana for cancer. CA Cancer J Clin. 2015;65(2):109–22.

    Article  PubMed  Google Scholar 

  164. Bennett M, Paice JA, Pain WM. Opioids in cancer care: benefits, risks, and alternatives. Am Soc Clin Oncol Educ Book. 2017;37:705–13.

    Article  PubMed  Google Scholar 

  165. 30 Legal Medical Marijuana States and DC. https://medicalmarijuana.procon.org/view.resource.php?resourceID=000881. Accessed 8 Dec 2017.

  166. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  167. Jongen HL, Huijsman ML, Jessurun J, Ogenio K, Schipper D, Verkouteren DR, et al. The evidence for pharmacological treatment of neuropathic cancer pain: beneficial and adverse effects. J Pain Symptom Manag. 2013;46(4):581–590e.

    Article  Google Scholar 

  168. Yaldo A, Wen L, Ogbonnaya A, Valderrama A, Kish J, Eaddy M, et al. Opioid use among metastatic prostate cancer patients with skeletal-related events. Clin Ther. 2016;38(8):1880–9.

    Article  CAS  PubMed  Google Scholar 

  169. Berenson J, Pfugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, et al. Balloon kyphoplasty vs non-surgical fracture management for treatment of painful vertebral compression fractures in patients with cancer: a randomized multicenter controlled trial. Lancet Oncol. 2011;12(3):225–35.

    Article  PubMed  Google Scholar 

  170. Marcus NJ. Pain in cancer patients unrelated to the cancer or treatment. Cancer Investig. 2005;23(1):84–93.

    Article  Google Scholar 

  171. Borg-Stein J, Iaccarino MA. Myofascial pain syndrome treatments. Phys Med Rehabil Clin N Am. 2014;25(2):357–74.

    Article  PubMed  Google Scholar 

  172. Ellison N, Loprinzi CL, Kugler J, Hatfield AK, Miser A, Sloan JA, et al. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol. 1997;15(8):2974–80.

    Article  CAS  PubMed  Google Scholar 

  173. Reddi D, Curran N. Chronic pain after surgery: pathophysiology, risk factors and prevention. Postgrad Med J. 2014;90(1062):222–7.

    Article  CAS  PubMed  Google Scholar 

  174. Lin X, Cavanagh HD. Ocular manifestations of graft-versus-host disease: 10 years’ experience. Clin Ophthalmol. 2015;9:1209–13.

    PubMed  PubMed Central  Google Scholar 

  175. Sherman RA. History of treatment attempts. In Sherman RA, editor. Phantom pain. Ray WJ, series editor, The plenum series in behavioral psychophysiology and medicine. New York: Plenum Publishing Corporation, 1996, pp. 143–148.

    Chapter  Google Scholar 

  176. Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc R Soc Lond B Biol Sci. 1996;263(1369):377–86.

    Article  CAS  Google Scholar 

  177. Huse E, Larbig W, Flor H, Birbaumer N. The effect of opioids on phantom limb pain and cortical reorganization. Pain. 2001;90(1–2):47–55.

    Article  CAS  PubMed  Google Scholar 

  178. Bone M, Critchley P, Buggy DJ. Gabapentin in post amputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study. Reg Anesth Pain Med. 2002;27(5):481–6.

    CAS  PubMed  Google Scholar 

  179. Ben Abraham RB, Marouani N, Weinbroum AA. Dextromethorphan mitigates phantom pain in cancer amputees. Ann Surg Oncol. 2003;10(3):268–74.

    Article  PubMed  Google Scholar 

  180. Nikolajsen L, Hansen CL, Nielsen J, et al. The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain. 1996;67(1):69–77.

    Article  CAS  PubMed  Google Scholar 

  181. Robinson LR, Czerniecki JM, Ehde DM, Edwards WT, Judish DA, Goldberg ML, et al. Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study. Arch Phys Med Rehabil. 2004;85(1):1–6.

    Article  PubMed  Google Scholar 

  182. Nagoshi Y, Watanabe A, Inoue S, Kuroda T, Nakamura M, Matsumoto Y, Fukui K. Usefulness of milnacipran in treating phantom limb pain. Neuropsychiatr Dis Treat. 2012;8:549–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  183. Alviar MJ, Hale T, Dungca M. Pharmacologic interventions for treating phantom limb pain. Cochrane Database Syst Rev. 2016;10:CD006380.

    PubMed  Google Scholar 

  184. McCormick Z, Chang-Chien G, Marshall B, Huang M, Harden RN. Phantom limb pain: a systematic neuroanatomical-based review of pharmacologic treatment. Pain Med. 2014;15(2):292–305.

    Article  PubMed  Google Scholar 

  185. Vasan CW, Liu WC, Klussmann JP, Guntinas-Lichius O. Botulinum toxin type A for the treatment of chronic neck pain after neck dissection. Head Neck. 2004;26(1):39–45.

    Article  PubMed  Google Scholar 

  186. McNeely ML, Parliament MB, Seikaly H, Jha N, Magee DJ, Haykowsky MJ, et al. Effect of exercise on upper extremity pain and dysfunction in head and neck cancer survivors: a randomized controlled trial. Cancer. 2008;113(1):214–22.

    Article  PubMed  Google Scholar 

  187. McNeely ML, Parliament MB, Seikaly H, Jha N, Magee DJ, Haykowsky MJ, et al. Sustainability of outcomes after a randomized crossover trial of resistance exercise for shoulder dysfunction in survivors of head and neck cancer. Physiother Can. 2015;67(1):85–93.

    Article  PubMed  PubMed Central  Google Scholar 

  188. Pfister DG, Cassileth BR, Deng GE, Yeung KS, Lee JS, Garrity D, et al. Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol. 2010;28(15):2565–70.

    Article  PubMed  PubMed Central  Google Scholar 

  189. Deganello A, Battat N, Muratori E, Cristofaro G, Buongiorno A, Mannelli G, et al. Acupuncture in shoulder pain and functional impairment after neck dissection: a prospective randomized pilot study. Laryngoscope. 2016;126(8):1790–5.

    Article  PubMed  Google Scholar 

  190. Larsson IM, Ahm Sørensen J, Bille C. The post-mastectomy pain syndrome- a systematic review of the treatment modalities. Breast J. 2017;23(3):338–43.

    Article  PubMed  Google Scholar 

  191. Kalso E, Tasmuth T, Neurvonen PJ. Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain. 1996;64(2):293–302.

    Article  CAS  Google Scholar 

  192. Tasmuth T, Hartel B, Kalso E. Venlafaxine in neuropathic pain following treatment of breast cancer. Eur J Pain. 2002;6(1):17–24.

    Article  CAS  PubMed  Google Scholar 

  193. Watson CP, Evans RJ, Watt VR. The post-mastectomy pain syndrome and the effect of topical capsaicin. Pain. 1989;38(2):177–86.

    Article  CAS  PubMed  Google Scholar 

  194. Dini D, Bertelli G, Gozza A, Forno GG. Treatment of the post-mastectomy pain syndrome with topical capsaicin. Pain. 1993;54(2):223–6.

    Article  CAS  PubMed  Google Scholar 

  195. Conacher ID. Therapists and therapies for post-thoracotomy neuralgia. Pain. 1992;48(3):409–12.

    Article  CAS  PubMed  Google Scholar 

  196. Bajwa ZH, Sami N, Warfield CA, Wootton J. Topiramate relieves refractory intercostal neuralgia. Neurology. 1999;52(9):1917.

    Article  CAS  PubMed  Google Scholar 

  197. Erdek MA, Staats PS. Chronic pain and thoracic surgery. Thorac Surg Clin. 2005;15(1):123–30.

    Article  PubMed  Google Scholar 

  198. Glantz L, Godovic G, Lekar M, Kramer M, Eidelman LA. Efficacy of transdermal nitroglycerin combined with etodolac for the treatment of chronic post-thoracotomy pain: an open label prospective clinical trial. J Pain Symptom Manag. 2004;27(3):277–81.

    Article  CAS  Google Scholar 

  199. Fu MR, Deng J, Arner JM. Putting evidence into practice: cancer related lymphedema. Evolving evidence for treatment and management from 2009-2014. Clin J Oncol Nurs. 2015;18(6):68–79.

    Google Scholar 

  200. Deng J, Radina E, Fu MR, Armer JM, Cormier JN, Thiadens SR, et al. Self-care status, symptom burden, and reported infections in individuals with lower-extremity primary lymphedema. J Nurs Scholarsh. 2015;47(2):126–34.

    Article  PubMed  Google Scholar 

  201. Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, et al. American Cancer Society Head and Neck cancer survivorship care guideline. CA Cancer J Clin. 2016;66(3):203–39.

    Article  PubMed  Google Scholar 

  202. Jaeckle KA. Neurologic manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol. 2010;30(3):254–62.

    Article  PubMed  Google Scholar 

  203. Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol. 2012;105(3):273–82.

    Article  PubMed  Google Scholar 

  204. Fathers E, Thrush D, Huson SM, Norman A. Radiation-induced brachial plexopathy in women treated for carcinoma of the breast. Clin Rehabil. 2002;16(2):160–5.

    Article  PubMed  Google Scholar 

  205. Schierle C, Winograd JM. Radiation-induced brachial plexopathy: review. Complication without a cure. J Reconstr Microsurg. 2004;20(2):149–52.

    Article  PubMed  Google Scholar 

  206. Zeidman SM, Rossitch EJ, Nahold BS Jr. Dorsal root entry zone lesions in the treatment of pain related to radiation-induced brachial plexopathy. J Spinal Disord. 1993;6(1):44–7.

    Article  CAS  PubMed  Google Scholar 

  207. Nich C, Bonnin P, Laredo JD, Sedel L. An uncommon form of delayed radio-induced brachial plexopathy. Chirurg Main. 2005;24(1):48–51.

    Article  CAS  Google Scholar 

  208. Pritchard J, Anand P, Broome J, Davis C, Gothard L, Hall E, et al. Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol. 2001;58(3):279–86.

    Article  CAS  PubMed  Google Scholar 

  209. Cooper J. Occupational therapy intervention with radiation-induced brachial plexopathy. Eur J Cancer Care. 1998;7(2):88–92.

    Article  CAS  Google Scholar 

  210. Stacey R, Green JT. Radiation induced small bowel disease: latest developments and clinical guidance. Therap Adv Chronic Dis. 2014;5(1):15–29.

    Article  Google Scholar 

  211. Teo MT, Sebag-Montefiore D, Donnellan CF. Prevention and management of radiation-induced late gastrointestinal toxicity. Clin Oncol (R Coll Radiol). 2015;27(11):656–67.

    Article  CAS  Google Scholar 

  212. Cho CH, Mathis JM, Ortiz O. Sacral fractures and sacroplasty. Neuroimaging Clin N Am. 2010;20(2):179–86.

    Article  PubMed  Google Scholar 

  213. Kortman K, Ortiz O, Miller T, Brook A, Tutton S, Mathis J, Georgy B. Multicenter study to assess the efficacy and safety of sacroplasty in patients with osteoporotic sacral insufficiency fractures or pathologic sacral lesions. J Neurointerv Surg. 2013;5(5):461–6.

    Article  PubMed  Google Scholar 

  214. Moussazadeh N, Laufer I, Werner T, Krol G, Boland P, Bilsky MH, Lis E. Sacroplasty for cancer-associated insufficiency fractures. Neurosurgery. 2015;76(4):446–50.

    Article  PubMed  Google Scholar 

  215. Dhanda J, Pasquier D, Newman L, Shaw R. Current concepts in osteoradionecrosis after head and neck radiotherapy. Clin Oncol (R Coll Radiol). 2016;28(7):459–66.

    Article  CAS  Google Scholar 

  216. Delanian S, Chatel C, Porcher R, Depondt J, Lefaix JL. Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial. Int J Radiat Oncol Biol Phys. 2011;80(3):832–9.

    Article  PubMed  Google Scholar 

  217. Majithia N, Temkin SM, Ruddy KJ, Beutler AS, Hershman DL, Loprinzi CL. National Cancer Institute-supported chemotherapy-induced peripheral neuropathy trials: outcomes and lessons. Support Care Cancer. 2016;24(3):1439–47.

    Article  PubMed  Google Scholar 

  218. Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309(13):1359–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  219. Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32(18):1941–67.

    Article  CAS  PubMed  Google Scholar 

  220. ASCO Guidelines, Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32(18):1941–67.

    Article  CAS  Google Scholar 

  221. Raja SN, Haythornthwaite JA, Pappagallo M, Clark MR, Travison TG, Sabeen S, et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology. 2002;59(7):1015–21.

    Article  CAS  PubMed  Google Scholar 

  222. Rowbotham MC, Reisner LA, Davies PS, Fields HL. Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial. J Pain. 2005;6(11):741–6.

    Article  CAS  PubMed  Google Scholar 

  223. Briot K, Tubiana-Hulin M, Bastit L, Kloos I, Roux C. Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study. Breast Cancer Res Treat. 2010;120(1):127–34.

    Article  CAS  PubMed  Google Scholar 

  224. Yang GS, Kim HJ, Griffith KA, Zhu S, Dorsey SG, Renn CL. Interventions for the treatment of aromatase inhibitor-associated arthralgia in breast cancer survivors. A systematic review and meta-analysis. Cancer Nurs. 2017;40(4):E26–41.

    Article  PubMed  Google Scholar 

  225. Irwin MI, Cartmel B, Gros CP, Ercolano E, Li F, Yao X, et al. Randomized exercise trial of aromatase-inhibitor-induced arthralgia in breast cancer survivors. J Clin Oncol. 2015;33(10):1104–11.

    Article  PubMed  Google Scholar 

  226. Goetsch M, Lim JY, Caughey AB. A practical solution for dyspareunia in breast cancer survivors: a randomized clinical trial. J Clin Oncol. 2015;33(30):3394–400.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  227. Marks C, Stadler M, Häusermann P, Wolff D, Buchholz S, Stary G, et al. German-Austrian-Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease (GVHD): guidance for supportive therapy of chronic cutaneous and musculoskeletal GVHD. Br J Dermatol. 2011;165(1):18–29.

    Article  CAS  PubMed  Google Scholar 

  228. Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, et al. International task force on osteonecrosis of the jaw. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30(1):3–23.

    Article  PubMed  Google Scholar 

  229. Waltho D, Rockwell D. Post breast surgery pain syndrome: establishing a consensus for the definition of post mastectomy pain syndrome to provide a standardized clinical and research approach – a review of the literature and discussion. Can J Surg. 2016;59(5):342–51.

    Article  PubMed  PubMed Central  Google Scholar 

  230. Werner MU, Kongsgaard UEI. Defining persistent post-surgical pain: is an update required? Br J Anaesth. 2014;113(1):1–4.

    Article  CAS  PubMed  Google Scholar 

  231. Paice J, Mulvey M, Bennett M, Dougherty PM, Farrar JT, Mantyh PW, et al. AAPT diagnostic criteria for chronic cancer pain conditions. J Pain. 2017;18(3):233–46.

    Article  PubMed  Google Scholar 

  232. Chawla N, Blanch-Hartigan D, Virgo KS, Ekwueme DU, Han X, Forsythe L, et al. Quality of patient-provider communication among cancer survivors: findings from a nationally representative sample. J Oncol Pract. 2016;12(12):e964–73.

    Article  PubMed  PubMed Central  Google Scholar 

  233. Gilligan T, Coyle N, Frankel RM, Berry DL, Bohlke K, Epstein RM, et al. Patient-clinician communication: American Society of Clinical Oncology consensus guideline. J Clin Oncol. 2017;35(31):3618–32.

    Article  PubMed  Google Scholar 

  234. Kvale EA, Huang CS, Meneses KM, Demark-Wahnefried W, Bae S, Azuero CB, et al. Patient-centered support in the survivorship care transition: outcomes from the patient-owned survivorship care plan intervention. Cancer. 2016;122(20):3232–42.

    Article  PubMed  Google Scholar 

  235. Peterson K, Anderson J, Bourne D, Mackey K, Helfand M. Evidence brief: effectiveness of models used to deliver multimodal care for chronic musculoskeletal pain. 2017 Jan. VA Evidence-based Synthesis Program Evidence Briefs [Internet]. Washington (DC): Department of Veterans Affairs (US);. Available from http://www.ncbi.nlm.nih.gov/books/NBK442254/.

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Chang, V.T., Kapoor-Hintzen, N. (2018). Pain. In: Feuerstein, M., Nekhlyudov, L. (eds) Handbook of Cancer Survivorship. Springer, Cham. https://doi.org/10.1007/978-3-319-77432-9_10

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