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Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions

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Cartilage Restoration

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Abstract

In the last two decades, the achievements of tissue engineering provided the surgeons with a pool of new and promising options for the treatment of cartilage defects. Cell-based regenerative techniques, also in combination with various biomaterials, were proposed to improve the tissue quality and the clinical outcomes. Despite several investigations that showed satisfactory clinical results in the long term, the need for two surgical procedures and the related costs limited their use. Thus, the possibility to avoid any cell augmentation by implanting biomaterials able to exploit the patient self-regenerative potential in situ was explored. Since then, several matrices were successfully introduced in the clinical use, and their intrinsic ability to promote tissue regeneration produced positive results in terms of clinical improvement. Also, some biomaterials were combined to reproduce the requirements of both bone and cartilage, in order to address osteochondral defects. This narrative review aims at resuming the state of the art concerning the clinical use of acellular scaffolds for the treatment of cartilage conditions.

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Author information

Authors and Affiliations

  1. NABI Laboratory, Rizzoli Orthopedic Institute IRCCS, Bologna, Italy

    Iacopo Romandini & Giuseppe Filardo

  2. II Orthopedic and Traumatologic Clinic, Rizzoli Orthopedic Institute IRCCS, Bologna, Italy

    Francesco Perdisa

  3. Department of Biomedical Sciences, Humanitas University, Milan, Italy

    Elizaveta Kon

  4. Humanitas Clinical and Research Center IRCCS, Milan, Italy

    Elizaveta Kon

Authors
  1. Iacopo Romandini
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  2. Francesco Perdisa
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  3. Giuseppe Filardo
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  4. Elizaveta Kon
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Corresponding author

Correspondence to Elizaveta Kon .

Editor information

Editors and Affiliations

  1. OrthoIndy Knee Preservation and Cartilage Restoration Center of Indiana, Indianapolis, Indiana, USA

    Jack Farr

  2. Department of Orthopedic Surgery, Hospital for Special Surgery, New York, New York, USA

    Andreas H. Gomoll

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Romandini, I., Perdisa, F., Filardo, G., Kon, E. (2018). Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions. In: Farr, J., Gomoll, A. (eds) Cartilage Restoration. Springer, Cham. https://doi.org/10.1007/978-3-319-77152-6_24

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  • DOI: https://doi.org/10.1007/978-3-319-77152-6_24

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