• Lewis Landsberg
Part of the Contemporary Endocrinology book series (COE)


Norepinephrine (NE), epinephrine (E), and dopamine are the naturally occurring biologically important catecholamines. E is the circulating hormone of the adrenal medulla, regulated by impulse traffic in the splanchnic nerves; NE is the adrenergic neurotransmitter released from peripheral sympathetic nerve endings in response to a downward flow of impulses from the sympathetic centers in the brainstem; and DA is formed in peripheral tissues from the decarboxylation of circulating DOPA. The physiologic effects of the catecholamines are mediated by cell surface receptors on effector cells. The excessive production of these compounds in pheochromocytomas and paragangliomas is responsible for the clinical manifestations of these tumors.


Norepinephrine Epinephrine Dopamine Adrenal medulla Sympathetic nervous system 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Northwestern UniversityFeinberg School of MedicineChicagoUSA

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