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Osteochondral Tissue Engineering pp 209–217Cite as

Nanoparticles-Based Systems for Osteochondral Tissue Engineering

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1059))

Abstract

Osteochondral lesions represent one of the major causes of disabilities in the world. These defects are due to degenerative or inflammatory arthritis, but both affect the articular cartilage and the underlying subchondral bone. Defects from trauma or degenerative pathology frequently cause severe pain, joint deformity, and loss of joint motion. Osteochondral defects are a significant challenge in orthopedic surgery, due to the cartilage complexity and unique structure, as well as its exposure to high pressure and motion. Although there are treatments routinely performed in the clinical practice, they present several limitations. Tissue engineering can be a suitable alternative for osteochondral defects since bone and cartilage engineering had experienced a notable advance over the years. Allied with nanotechnology, osteochondral tissue engineering (OCTE) can be leveled up, being possible to create advanced structures similar to the OC tissue. In this chapter, the current strategies using nanoparticles-based systems are overviewed. The results of the studies herein considered confirm that advanced nanomaterials will undoubtedly play a crucial role in the design of strategies for treatment of osteochondral defects in the near future.

*These authors contributed equally to this chapter.

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Author information

Author notes

  1. Isabel Oliveira & Sílvia Vieira

    Present address: ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

Authors and Affiliations

  1. 3B’s Research Group – Biomolecules, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Isabel Oliveira, Sílvia Vieira, J. Miguel Oliveira & Rui L. Reis

  2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    J. Miguel Oliveira & Rui L. Reis

  3. The Discoveries Center for Regenerative and Precision Medicine, Headquarters at University of Minho, Barco/Guimarães, Portugal

    J. Miguel Oliveira & Rui L. Reis

Authors
  1. Isabel Oliveira
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  2. Sílvia Vieira
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  3. J. Miguel Oliveira
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  4. Rui L. Reis
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Corresponding author

Correspondence to J. Miguel Oliveira .

Editor information

Editors and Affiliations

  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    J. Miguel Oliveira

  2. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Sandra Pina

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Rui L. Reis

  4. Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

    Julio San Roman

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Oliveira, I., Vieira, S., Oliveira, J.M., Reis, R.L. (2018). Nanoparticles-Based Systems for Osteochondral Tissue Engineering. In: Oliveira, J., Pina, S., Reis, R., San Roman, J. (eds) Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1059. Springer, Cham. https://doi.org/10.1007/978-3-319-76735-2_9

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